RCBT2_MOUSE
ID RCBT2_MOUSE Reviewed; 551 AA.
AC Q99LJ7; G1EE51; Q3TUA3; Q8BMG2;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=RCC1 and BTB domain-containing protein 2;
DE AltName: Full=Chromosome condensation 1-like;
DE AltName: Full=Regulator of chromosome condensation and BTB domain-containing protein 2;
GN Name=Rcbtb2; Synonyms=Chc1l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND DOMAIN.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AEK06434.1};
RX PubMed=22768142; DOI=10.1371/journal.pone.0039846;
RA Wang J., Teves M.E., Shen X., Nagarkatti-Gude D.R., Hess R.A.,
RA Henderson S.C., Strauss J.F. III, Zhang Z.;
RT "Mouse RC/BTB2, a member of the RCC1 superfamily, localizes to spermatid
RT acrosomal vesicles.";
RL PLoS ONE 7:E39846-E39846(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Forelimb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC {ECO:0000269|PubMed:22768142}. Note=Mainly found in the acrosomal cap
CC region. {ECO:0000269|PubMed:22768142}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q99LJ7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q99LJ7-2; Sequence=VSP_016724;
CC -!- TISSUE SPECIFICITY: Expressed in testis and heart (at protein level).
CC {ECO:0000269|PubMed:22768142}.
CC -!- DEVELOPMENTAL STAGE: Expressed in testis from postnatal day 12 onwards,
CC reaching maximal levels at postnatal day 30 (at protein level).
CC {ECO:0000269|PubMed:22768142}.
CC -!- DOMAIN: The BTB domain might play a role in targeting to acrosomal
CC vesicles. {ECO:0000269|PubMed:22768142}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; JN086338; AEK06433.1; -; mRNA.
DR EMBL; JN086339; AEK06434.1; -; mRNA.
DR EMBL; AK031242; BAC27316.1; -; mRNA.
DR EMBL; AK031248; BAC27319.1; -; mRNA.
DR EMBL; AK160881; BAE36068.1; -; mRNA.
DR EMBL; CT571265; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466535; EDL35861.1; -; Genomic_DNA.
DR EMBL; BC003224; AAH03224.1; -; mRNA.
DR CCDS; CCDS27266.1; -. [Q99LJ7-1]
DR RefSeq; NP_001164165.1; NM_001170694.1. [Q99LJ7-1]
DR RefSeq; NP_598844.3; NM_134083.4. [Q99LJ7-1]
DR RefSeq; XP_006518445.1; XM_006518382.3. [Q99LJ7-1]
DR RefSeq; XP_006518446.1; XM_006518383.2. [Q99LJ7-1]
DR RefSeq; XP_006518447.1; XM_006518384.1. [Q99LJ7-1]
DR RefSeq; XP_006518448.1; XM_006518385.3. [Q99LJ7-1]
DR RefSeq; XP_006518449.1; XM_006518386.2. [Q99LJ7-2]
DR RefSeq; XP_011243193.1; XM_011244891.2. [Q99LJ7-1]
DR AlphaFoldDB; Q99LJ7; -.
DR SMR; Q99LJ7; -.
DR BioGRID; 222895; 1.
DR STRING; 10090.ENSMUSP00000131588; -.
DR iPTMnet; Q99LJ7; -.
DR PhosphoSitePlus; Q99LJ7; -.
DR EPD; Q99LJ7; -.
DR MaxQB; Q99LJ7; -.
DR PaxDb; Q99LJ7; -.
DR PeptideAtlas; Q99LJ7; -.
DR PRIDE; Q99LJ7; -.
DR ProteomicsDB; 254904; -. [Q99LJ7-1]
DR ProteomicsDB; 254905; -. [Q99LJ7-2]
DR Antibodypedia; 23851; 192 antibodies from 28 providers.
DR DNASU; 105670; -.
DR Ensembl; ENSMUST00000022702; ENSMUSP00000022702; ENSMUSG00000022106. [Q99LJ7-1]
DR Ensembl; ENSMUST00000110952; ENSMUSP00000106577; ENSMUSG00000022106. [Q99LJ7-1]
DR Ensembl; ENSMUST00000164822; ENSMUSP00000131588; ENSMUSG00000022106. [Q99LJ7-1]
DR Ensembl; ENSMUST00000169479; ENSMUSP00000126898; ENSMUSG00000022106. [Q99LJ7-1]
DR Ensembl; ENSMUST00000169513; ENSMUSP00000128579; ENSMUSG00000022106. [Q99LJ7-2]
DR Ensembl; ENSMUST00000170677; ENSMUSP00000126510; ENSMUSG00000022106. [Q99LJ7-2]
DR GeneID; 105670; -.
DR KEGG; mmu:105670; -.
DR UCSC; uc007upj.2; mouse. [Q99LJ7-1]
DR CTD; 1102; -.
DR MGI; MGI:1917200; Rcbtb2.
DR VEuPathDB; HostDB:ENSMUSG00000022106; -.
DR eggNOG; KOG1426; Eukaryota.
DR GeneTree; ENSGT00940000158925; -.
DR HOGENOM; CLU_029788_1_0_1; -.
DR InParanoid; Q99LJ7; -.
DR OMA; ATFYREM; -.
DR OrthoDB; 1062377at2759; -.
DR PhylomeDB; Q99LJ7; -.
DR TreeFam; TF329478; -.
DR BioGRID-ORCS; 105670; 1 hit in 57 CRISPR screens.
DR ChiTaRS; Rcbtb2; mouse.
DR PRO; PR:Q99LJ7; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q99LJ7; protein.
DR Bgee; ENSMUSG00000022106; Expressed in ear vesicle and 246 other tissues.
DR ExpressionAtlas; Q99LJ7; baseline and differential.
DR Genevisible; Q99LJ7; MM.
DR GO; GO:0001669; C:acrosomal vesicle; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR Gene3D; 2.130.10.30; -; 1.
DR Gene3D; 3.30.710.10; -; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF00415; RCC1; 4.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF50985; SSF50985; 1.
DR SUPFAM; SSF54695; SSF54695; 1.
DR PROSITE; PS50097; BTB; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 4.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasmic vesicle; Reference proteome; Repeat.
FT CHAIN 1..551
FT /note="RCC1 and BTB domain-containing protein 2"
FT /id="PRO_0000206645"
FT REPEAT 64..115
FT /note="RCC1 1"
FT /evidence="ECO:0000255"
FT REPEAT 117..169
FT /note="RCC1 2"
FT /evidence="ECO:0000255"
FT REPEAT 171..222
FT /note="RCC1 3"
FT /evidence="ECO:0000255"
FT REPEAT 223..274
FT /note="RCC1 4"
FT /evidence="ECO:0000255"
FT REPEAT 276..326
FT /note="RCC1 5"
FT /evidence="ECO:0000255"
FT REPEAT 328..382
FT /note="RCC1 6"
FT /evidence="ECO:0000255"
FT DOMAIN 394..457
FT /note="BTB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT VAR_SEQ 1..24
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_016724"
FT CONFLICT 211
FT /note="A -> S (in Ref. 2; BAC27316)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 551 AA; 60164 MW; 6D54A19067688609 CRC64;
MEEEVPGFYG ESGKSVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV FGSAGNEVLY
TTVNDEIFVL GTNCSGCLGV GDIQSTIEPR RLDSLTGKKI ASLSYGSGPH IVLATTDGEV
FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS NKQVIEVACG SYHSLVLTSD GEVFAWGYNN
SGQVGSGSTA NQPIPRRVTG CLQNKVVMNI ACGQMCSMAV VDTGEVYVWG YNGNGQLGLG
SSGNQPTPCR VAALQGIRVQ RVACGYAHTL VLTDEGQIYA WGANSYGQLG TGNKSNQSYP
TPVVVEKDRI IEIAACHSAH TSAAKTQGGH VYMWGQCRGQ SVILPHHTHF CCTDDVFACF
ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV DGKYIYAHKV LLKIRCEHFR
SSLEDSEDDI VEMSEFSYPV FRAFLEYLYT DNISLSPEEA VGLLDLATFY SETRLKKLCQ
QTIKQGICEE NAIALLSAAV KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI
SKASRVGAFK N
