ID   RCBT2_PONAB             Reviewed;         551 AA.
AC   Q5RCZ7; Q5R8I9; Q5RE90;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=RCC1 and BTB domain-containing protein 2;
DE   AltName: Full=Regulator of chromosome condensation and BTB domain-containing protein 2;
GN   Name=RCBTB2;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Heart, and Kidney;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000250|UniProtKB:Q99LJ7}. Note=Mainly found in the acrosomal cap
CC       region. {ECO:0000250|UniProtKB:Q99LJ7}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q5RCZ7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q5RCZ7-2; Sequence=VSP_016725;
CC   -!- DOMAIN: The BTB domain might play a role in targeting to acrosomal
CC       vesicles. {ECO:0000250|UniProtKB:Q99LJ7}.
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DR   EMBL; CR857643; CAH89917.1; -; mRNA.
DR   EMBL; CR858121; CAH90360.1; -; mRNA.
DR   EMBL; CR859763; CAH91921.1; -; mRNA.
DR   RefSeq; NP_001125174.1; NM_001131702.1. [Q5RCZ7-1]
DR   RefSeq; NP_001128757.1; NM_001135285.1.
DR   AlphaFoldDB; Q5RCZ7; -.
DR   SMR; Q5RCZ7; -.
DR   STRING; 9601.ENSPPYP00000006106; -.
DR   Ensembl; ENSPPYT00000006345; ENSPPYP00000006106; ENSPPYG00000005361. [Q5RCZ7-1]
DR   GeneID; 100172062; -.
DR   KEGG; pon:100172062; -.
DR   CTD; 1102; -.
DR   eggNOG; KOG1426; Eukaryota.
DR   GeneTree; ENSGT00940000158925; -.
DR   HOGENOM; CLU_029788_1_0_1; -.
DR   InParanoid; Q5RCZ7; -.
DR   OMA; ATFYREM; -.
DR   TreeFam; TF329478; -.
DR   Proteomes; UP000001595; Chromosome 13.
DR   GO; GO:0001669; C:acrosomal vesicle; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.130.10.30; -; 2.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00415; RCC1; 4.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF50985; SSF50985; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00626; RCC1_2; 1.
DR   PROSITE; PS50012; RCC1_3; 4.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Cytoplasmic vesicle; Reference proteome; Repeat.
FT   CHAIN           1..551
FT                   /note="RCC1 and BTB domain-containing protein 2"
FT                   /id="PRO_0000206646"
FT   REPEAT          64..115
FT                   /note="RCC1 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          117..169
FT                   /note="RCC1 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          171..222
FT                   /note="RCC1 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          223..274
FT                   /note="RCC1 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          276..326
FT                   /note="RCC1 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          328..382
FT                   /note="RCC1 6"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          394..457
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   VAR_SEQ         1..24
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_016725"
FT   CONFLICT        84
FT                   /note="Q -> R (in Ref. 1; CAH91921)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        417
FT                   /note="E -> G (in Ref. 1; CAH89917)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   551 AA;  60315 MW;  0965A7FAC8143F03 CRC64;
     MEEELPLFSG DSGKPVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV FGSAGNEVLY
     TTVNDEIFVL GTNCCGCLGL GDVQSTIEPR RLDSLNGKKI ACLSYGSGPH IVLATTEGEV
     FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS NKQVIEVACG SYHSLVLTSD GEVFAWGYNN
     SGQVGSGSTV NQPIPRRVTG CLQNKVVVTI ACGQMCCMAV VDTGEVYVWG YNGNGQLGLG
     NSGNQPTPCR VAALQGIRVQ RVACGYAHTL VLTDEGQVYA WGANSYGQLG TGNKSNQSYP
     TPVTVEKDRI IEIAACHSTH TSAAKTQGGH VYMWGQCRGQ SVILPHLTHF SCTDDVFACF
     ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV DGKYIYAHKV LLKIRCEHFR
     SSLEDNEDDI VEMSEFSYPV YRAFLEYLYT DSISLSPEEA VGLLDLATFY RENRLKKLCQ
     QTIKQGICEE NAIALLSAAV KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI
     SKASRVGAFK N