ID   RCBT2_RAT               Reviewed;         551 AA.
AC   Q6P798;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=RCC1 and BTB domain-containing protein 2;
DE   AltName: Full=Chromosome condensation 1-like;
DE   AltName: Full=Regulator of chromosome condensation and BTB domain-containing protein 2;
GN   Name=Rcbtb2; Synonyms=Chc1l;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Prostate;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC       {ECO:0000250|UniProtKB:Q99LJ7}. Note=Mainly found in the acrosomal cap
CC       region. {ECO:0000250|UniProtKB:Q99LJ7}.
CC   -!- DOMAIN: The BTB domain might play a role in targeting to acrosomal
CC       vesicles. {ECO:0000250|UniProtKB:Q99LJ7}.
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DR   EMBL; BC061766; AAH61766.1; -; mRNA.
DR   RefSeq; NP_954515.1; NM_199084.1.
DR   RefSeq; XP_008769067.1; XM_008770845.2.
DR   RefSeq; XP_008769068.1; XM_008770846.2.
DR   RefSeq; XP_008769069.1; XM_008770847.2.
DR   RefSeq; XP_008769070.1; XM_008770848.1.
DR   RefSeq; XP_008769071.1; XM_008770849.2.
DR   RefSeq; XP_008769072.1; XM_008770850.2.
DR   AlphaFoldDB; Q6P798; -.
DR   SMR; Q6P798; -.
DR   IntAct; Q6P798; 2.
DR   STRING; 10116.ENSRNOP00000020836; -.
DR   PaxDb; Q6P798; -.
DR   PRIDE; Q6P798; -.
DR   Ensembl; ENSRNOT00000020836; ENSRNOP00000020836; ENSRNOG00000015054.
DR   GeneID; 290363; -.
DR   KEGG; rno:290363; -.
DR   UCSC; RGD:735048; rat.
DR   CTD; 1102; -.
DR   RGD; 735048; Rcbtb2.
DR   eggNOG; KOG1426; Eukaryota.
DR   GeneTree; ENSGT00940000158925; -.
DR   HOGENOM; CLU_029788_1_0_1; -.
DR   InParanoid; Q6P798; -.
DR   OMA; ATFYREM; -.
DR   OrthoDB; 1062377at2759; -.
DR   PhylomeDB; Q6P798; -.
DR   TreeFam; TF329478; -.
DR   PRO; PR:Q6P798; -.
DR   Proteomes; UP000002494; Chromosome 15.
DR   Bgee; ENSRNOG00000015054; Expressed in liver and 19 other tissues.
DR   Genevisible; Q6P798; RN.
DR   GO; GO:0001669; C:acrosomal vesicle; ISO:RGD.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   Gene3D; 2.130.10.30; -; 1.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00415; RCC1; 4.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SMART; SM00225; BTB; 1.
DR   SUPFAM; SSF50985; SSF50985; 1.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00626; RCC1_2; 1.
DR   PROSITE; PS50012; RCC1_3; 4.
PE   2: Evidence at transcript level;
KW   Cytoplasmic vesicle; Reference proteome; Repeat.
FT   CHAIN           1..551
FT                   /note="RCC1 and BTB domain-containing protein 2"
FT                   /id="PRO_0000206647"
FT   REPEAT          64..115
FT                   /note="RCC1 1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          117..169
FT                   /note="RCC1 2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          171..222
FT                   /note="RCC1 3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          223..274
FT                   /note="RCC1 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          276..326
FT                   /note="RCC1 5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          328..382
FT                   /note="RCC1 6"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          394..457
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
SQ   SEQUENCE   551 AA;  60123 MW;  D77565DDA0C25048 CRC64;
     MEEEVPGFYG ESGKSVQATL SSLKMLDVGK WPIFSLCSEE ELQLIRQACV FGTAGNEVLY
     TTVNDEIFVL GTNCSGCLGV GDIQSTIEPR RLDSLTGKKI ASLSYGSGPH IVLATTDGEV
     FTWGHNAYSQ LGNGTTNHGL VPCHISTNLS NKQVIEVACG SYHSLVLTSD GEVFAWGYNN
     SGQVGSGSTA NQPIPRRVTG CLQNKVVMSI ACGQMCSMAV VDTGEVYVWG YNGNGQLGLG
     SSGNQPTPCR VAALQGIRVQ RVACGYAHTL VLTDEGQIYA WGANSYGQLG TGNKSNQSYP
     TPVVVEKDRI IEIAACHSAH TSAAKSQGGH VYMWGQCRGQ SVILPHLTHF CCTDDVFACF
     ATPAVTWRLL SVEPDDHLTV AESLKREFDN PDTADLKFLV DGKYIYAHKV LLKIRCEHFR
     SSLEDSEDDI VEMSEFSYPV FRAFLEYLYT DNISLPPEEA VGLLDLATFY SETRLKKLCQ
     QTIKQGICEE NAIALLSAAV KYDAQDLEEF CFRFCINHLT VVTQTSGFAE MDHDLLKNFI
     SKASRVGAFK N