RCC1_CAEEL
ID RCC1_CAEEL Reviewed; 569 AA.
AC Q18211;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Regulator of chromosome condensation;
DE AltName: Full=Cell cycle regulatory protein;
DE AltName: Full=RCC1 homolog;
GN Name=ran-3; ORFNames=C26D10.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|EMBL:CAA91119.1};
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=11909538; DOI=10.1016/s0960-9822(02)00741-8;
RA Bamba C., Bobinnec Y., Fukuda M., Nishida E.;
RT "The GTPase Ran regulates chromosome positioning and nuclear envelope
RT assembly in vivo.";
RL Curr. Biol. 12:503-507(2002).
CC -!- FUNCTION: Key component of the Ran GTPase system, which comprises ran-
CC 1, ran-2 and ran-3 and is essential in nucleocytoplasmic transport.
CC Promotes the exchange of Ran-bound GDP by GTP and regulates the onset
CC of chromosome condensation in the S phase. Binds to the chromatin. RCC1
CC (ran-3)/RAN (ran-1) complex (together with other proteins) acts as a
CC component of a signal transmission pathway that detects unreplicated
CC DNA. {ECO:0000269|PubMed:11909538}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11909538}.
CC -!- MISCELLANEOUS: Loss of ran-3 causes low levels of chromosomes to
CC misalign on the metaphase plate and segregate incorrectly in early
CC embryonic cell divisions. {ECO:0000269|PubMed:11909538}.
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DR EMBL; Z54327; CAA91119.1; -; Genomic_DNA.
DR PIR; T19483; T19483.
DR RefSeq; NP_495753.1; NM_063352.4.
DR AlphaFoldDB; Q18211; -.
DR SMR; Q18211; -.
DR BioGRID; 39661; 14.
DR IntAct; Q18211; 1.
DR STRING; 6239.C26D10.1; -.
DR iPTMnet; Q18211; -.
DR EPD; Q18211; -.
DR PaxDb; Q18211; -.
DR PeptideAtlas; Q18211; -.
DR PRIDE; Q18211; -.
DR EnsemblMetazoa; C26D10.1.1; C26D10.1.1; WBGene00004304.
DR GeneID; 174332; -.
DR KEGG; cel:CELE_C26D10.1; -.
DR UCSC; C26D10.1; c. elegans.
DR CTD; 174332; -.
DR WormBase; C26D10.1; CE03024; WBGene00004304; ran-3.
DR eggNOG; KOG1426; Eukaryota.
DR GeneTree; ENSGT00940000174254; -.
DR HOGENOM; CLU_034497_0_0_1; -.
DR InParanoid; Q18211; -.
DR OMA; TFRKNEG; -.
DR OrthoDB; 1062377at2759; -.
DR PhylomeDB; Q18211; -.
DR Reactome; R-CEL-9615933; Postmitotic nuclear pore complex (NPC) reformation.
DR PRO; PR:Q18211; -.
DR Proteomes; UP000001940; Chromosome II.
DR Bgee; WBGene00004304; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0009792; P:embryo development ending in birth or egg hatching; IMP:WormBase.
DR GO; GO:0110039; P:positive regulation of nematode male tail tip morphogenesis; IMP:UniProtKB.
DR Gene3D; 2.130.10.30; -; 1.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR Pfam; PF00415; RCC1; 1.
DR PRINTS; PR00633; RCCNDNSATION.
DR SUPFAM; SSF50985; SSF50985; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 3.
PE 4: Predicted;
KW Cell cycle; Cell division; Guanine-nucleotide releasing factor; Mitosis;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1..569
FT /note="Regulator of chromosome condensation"
FT /id="PRO_0000206632"
FT REPEAT 263..318
FT /note="RCC1 1"
FT /evidence="ECO:0000305"
FT REPEAT 388..452
FT /note="RCC1 2"
FT /evidence="ECO:0000305"
FT REPEAT 511..568
FT /note="RCC1 3"
FT /evidence="ECO:0000305"
FT REGION 1..130
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 108..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 569 AA; 61485 MW; ED487D2CAA45AFBA CRC64;
MSTAEQRMDT SEVELPNDNV NEQGNKTPRA DQPESSASGA RNHGEDEEVT EQVELAAMET
EASDSIVDNV PKTPRRAGRP KKLPSTSTAA AESAVTPGKR GRKRKGSESV NTTINSTMNS
TLNEPKTPGR KQAKLVAPLL TYDLFAPSII GDRVLSCGEG EALGHPGRTT TKKPRKVDIF
EEEGLKPLQA VAGGVHSAVL TSEGEVYMCG INEKGTVPAE GVEKEGSTDE FAKVKFEEDI
EKEGKIVMLA AGASFTAALT DQGSVIAWGN LRNSNGNVDV HPLLHKMQEA PVVIVHQAKR
KIVKIAAGEN HLVMLDEKGC LLTFGDGEMG QLGRSSRTKT IRSKYMCDES GDHLLVPLRF
KHKGKFFDVV AKNVFASGFW TIVHGEDGKY YAFGLNNYAQ LGIKVDEADV GQDGQDNREL
RVFLPAEAPA FGAERTFVNI EGVQHVVILG SDGKVFAMGK NTDNALGLGN WTGKDDQQHW
LYDTIQEIEF DSKIVGVSAK LATSIAWSED GTAYAWGFDT TGQLGLGLKD EDEKMVSKPE
EISSAHLDGY SIIGASISDQ HTLIIAKKN
