ID   RCC1_XENLA              Reviewed;         424 AA.
AC   P25183;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Regulator of chromosome condensation;
GN   Name=rcc1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX   PubMed=2361953; DOI=10.1093/oxfordjournals.jbchem.a123031;
RA   Nishitani H., Kobayashi H., Ohtsubo M., Nishimoto T.;
RT   "Cloning of Xenopus RCC1 cDNA, a homolog of the human RCC1 gene:
RT   complementation of tsBN2 mutation and identification of the product.";
RL   J. Biochem. 107:228-235(1990).
CC   -!- FUNCTION: Guanine-nucleotide releasing factor that promotes the
CC       exchange of Ran-bound GDP by GTP, and thereby plays an important role
CC       in RAN-mediated functions in nuclear import and mitosis. Contributes to
CC       the generation of high levels of chromosome-associated, GTP-bound RAN,
CC       which is important for mitotic spindle assembly and normal progress
CC       through mitosis. Via its role in maintaining high levels of GTP-bound
CC       RAN in the nucleus, contributes to the release of cargo proteins from
CC       importins after nuclear import (By similarity). Involved in the
CC       regulation of onset of chromosome condensation in the S phase
CC       (PubMed:2361953). Binds both to the nucleosomes and double-stranded DNA
CC       (By similarity). {ECO:0000250|UniProtKB:P18754,
CC       ECO:0000269|PubMed:2361953}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P18754}.
CC       Chromosome {ECO:0000250|UniProtKB:P18754}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P18754}. Note=Predominantly nuclear in
CC       interphase cells. Binds to mitotic chromosomes.
CC       {ECO:0000250|UniProtKB:P18754}.
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DR   EMBL; D00679; BAA00586.1; -; mRNA.
DR   EMBL; D00646; BAA00542.1; -; mRNA.
DR   PIR; I51559; I51559.
DR   RefSeq; NP_001081229.1; NM_001087760.1.
DR   AlphaFoldDB; P25183; -.
DR   SMR; P25183; -.
DR   BioGRID; 99062; 1.
DR   DNASU; 397722; -.
DR   GeneID; 397722; -.
DR   KEGG; xla:397722; -.
DR   CTD; 397722; -.
DR   Xenbase; XB-GENE-6252622; rcc1.L.
DR   OrthoDB; 1062377at2759; -.
DR   Proteomes; UP000186698; Chromosome 2L.
DR   Bgee; 397722; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.30; -; 1.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   Pfam; PF00415; RCC1; 7.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SUPFAM; SSF50985; SSF50985; 1.
DR   PROSITE; PS00625; RCC1_1; 1.
DR   PROSITE; PS00626; RCC1_2; 5.
DR   PROSITE; PS50012; RCC1_3; 7.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Chromosome; Cytoplasm;
KW   Guanine-nucleotide releasing factor; Mitosis; Nucleus; Reference proteome;
KW   Repeat.
FT   CHAIN           1..424
FT                   /note="Regulator of chromosome condensation"
FT                   /id="PRO_0000206631"
FT   REPEAT          40..90
FT                   /note="RCC1 1"
FT   REPEAT          91..142
FT                   /note="RCC1 2"
FT   REPEAT          144..195
FT                   /note="RCC1 3"
FT   REPEAT          197..262
FT                   /note="RCC1 4"
FT   REPEAT          263..316
FT                   /note="RCC1 5"
FT   REPEAT          317..367
FT                   /note="RCC1 6"
FT   REPEAT          368..421
FT                   /note="RCC1 7"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         27..30
FT                   /note="Missing (in clone lambda O-23)"
SQ   SEQUENCE   424 AA;  45071 MW;  DCF77FCCEBAB6639 CRC64;
     MKGKKTLKRT IAAEESNGTS DVKKTKALPI VTHPSHGTVG GQVLTLGQGD VGQLGLGEDI
     MERKKPALVT LTEDIVQAAA GGMHTVCLGA SGSIYTFGCN DEGALGRDTS EEGSEMQPGK
     VELAEKVVQV SAGDSHTAAL TEDGRVFVFG SFRDNNGVIG LLEPMKKSMV PVQVQINTPV
     IKIASGNDHL VLLTVDGDLY TSGCGEQGQL GRVPERFTNR GGRKGLERLL VPQCIHLKAK
     GSGRVHFQDV FCGAYFTFAV SQEGHVYGFG LSNYHQLGTK NTQACYAPQN LTSFKNSTKS
     WIGFSGGQHH TVCVDSEGKA YSLGRAEYGR LGLGENAEEQ SEPTPIPDLP KINSVASGAS
     VSYAVSTDGC VFAWGMGTNL QLGTGEEEDV WSPEQMTGKH LEDREVLSVS SGGQHTVLLV
     RKRS