ID   RCC2_XENLA              Reviewed;         513 AA.
AC   Q52KW8;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=Protein RCC2 homolog;
GN   Name=rcc2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Multifunctional protein that may affect its functions by
CC       regulating the activity of small GTPases, such as RAC1 and RALA.
CC       Required for normal progress through the cell cycle, both during
CC       interphase and during mitosis. Required for normal attachment of
CC       kinetochores to mitotic spindles. Required for normal organization of
CC       the microtubule cytoskeleton in interphase cells. Interferes with the
CC       activation of RAC1 by guanine nucleotide exchange factors. Prevents
CC       accumulation of active, GTP-bound RAC1, and suppresses RAC1-mediated
CC       reorganization of the actin cytoskeleton and formation of membrane
CC       protrusions. Required for normal cellular responses to contacts with
CC       the extracellular matrix of adjacent cells, and for directional cell
CC       migration. {ECO:0000250|UniProtKB:Q9P258}.
CC   -!- SUBUNIT: Interacts with RAC1. Interacts with CORO1C.
CC       {ECO:0000250|UniProtKB:Q9P258}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:Q9P258}. Nucleus {ECO:0000250|UniProtKB:Q9P258}.
CC       Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q9P258}. Chromosome,
CC       centromere {ECO:0000250|UniProtKB:Q9P258}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250|UniProtKB:Q9P258}. Chromosome
CC       {ECO:0000250|UniProtKB:Q9P258}. Midbody {ECO:0000250|UniProtKB:Q9P258}.
CC       Cell membrane {ECO:0000250|UniProtKB:Q9P258}; Peripheral membrane
CC       protein {ECO:0000250|UniProtKB:Q9P258}; Cytoplasmic side
CC       {ECO:0000250|UniProtKB:Q9P258}.
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DR   EMBL; BC094159; AAH94159.1; -; mRNA.
DR   RefSeq; NP_001089405.1; NM_001095936.1.
DR   RefSeq; XP_018080104.1; XM_018224615.1.
DR   AlphaFoldDB; Q52KW8; -.
DR   SMR; Q52KW8; -.
DR   BioGRID; 592236; 1.
DR   DNASU; 734455; -.
DR   GeneID; 734455; -.
DR   KEGG; xla:734455; -.
DR   CTD; 734455; -.
DR   Xenbase; XB-GENE-996300; rcc2.L.
DR   OMA; YGCLSGI; -.
DR   OrthoDB; 1062377at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 734455; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0000775; C:chromosome, centromeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.30; -; 2.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR028641; RCC2.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   PANTHER; PTHR46207; PTHR46207; 1.
DR   Pfam; PF00415; RCC1; 4.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SUPFAM; SSF50985; SSF50985; 1.
DR   PROSITE; PS00626; RCC1_2; 1.
DR   PROSITE; PS50012; RCC1_3; 5.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Cell membrane; Centromere; Chromosome;
KW   Cytoplasm; Cytoskeleton; Membrane; Mitosis; Nucleus; Reference proteome;
KW   Repeat.
FT   CHAIN           1..513
FT                   /note="Protein RCC2 homolog"
FT                   /id="PRO_0000206655"
FT   REPEAT          94..156
FT                   /note="RCC1 1"
FT   REPEAT          159..210
FT                   /note="RCC1 2"
FT   REPEAT          212..262
FT                   /note="RCC1 3"
FT   REPEAT          264..338
FT                   /note="RCC1 4"
FT   REPEAT          339..392
FT                   /note="RCC1 5"
FT   REPEAT          394..438
FT                   /note="RCC1 6"
FT   REPEAT          439..492
FT                   /note="RCC1 7"
FT   REGION          1..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          309..316
FT                   /note="Required for interaction with RAC1"
FT                   /evidence="ECO:0000250|UniProtKB:Q9P258"
FT   REGION          492..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   513 AA;  55496 MW;  D48EF545DA41751B CRC64;
     MPRKKVTDGS GPGNGAARPA NRKKAAASGK KRSRHEFSSD EDDLDGSPGS DGGFQGHNNK
     RGPAKGATKA PTAVIVTEPE HSKEKIKLEG SKAKGQLLIF GATNWDLIGR KEVPKQQAAY
     RNLGQNLWGP HRYGCLTGVQ VRSVASGSCA AHSLLITVEG KLWSWGRNDK GQLGHGDIKR
     IDVPKLIESL KGEVFVHAAC GRNHTLALTE NGSVYAFGEN KMGQLGLGNK TDAVPSPAQI
     LYNGQPITKV ACGAEFSMIM DCKGNLYSFG CPEYGQLGHN SDGKYIARAQ RIEYDCELIA
     RRIAIFIEKT KDGQILPVPN VVVRDIACGI NHSLILDSQK RVFSWGFGGY GRLGHSEQRD
     EMVPRLVKLF DFPGRGAAQI YAGATCSFAV SEMGGLFFWG ATNTSRDSTM YPKAVQDLCG
     WKVRSLACGK SSIIVAADES TISWGPSPTF GELGYGDNKA KSSTTAQEVK TLDGIYSDQV
     IMGNSHTLVV ARDETEQDKE KLKKLPEYNP RTL