ID   RCCD1_MACFA             Reviewed;         376 AA.
AC   Q4R828;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 54.
DE   RecName: Full=RCC1 domain-containing protein 1;
GN   Name=RCCD1; ORFNames=QtsA-13681;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays a role in transcriptional repression of satellite
CC       repeats, possibly by regulating H3K36 methylation levels in centromeric
CC       regions together with KDM8. Possibly together with KDM8, is involved in
CC       proper mitotic spindle organization and chromosome segregation. Plays a
CC       role in regulating alpha-tubulin deacetylation and cytoskeletal
CC       microtubule stability, thereby promoting cell migration and TGF-beta-
CC       induced epithelial to mesenchymal transition (EMT), potentially through
CC       the inhibition of KDM8. {ECO:0000250|UniProtKB:A6NED2}.
CC   -!- SUBUNIT: Found in a complex with KDM8. Interacts (via N-terminus) with
CC       KDM8 (via N-terminus). {ECO:0000250|UniProtKB:A6NED2}.
CC   -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:A6NED2}.
CC       Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3).
CC       {ECO:0000250|UniProtKB:A6NED2}.
CC   -!- PTM: Specifically hydroxylated (with R stereochemistry) at C-3 of ARG-
CC       141 by KDM8. {ECO:0000250|UniProtKB:A6NED2}.
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DR   EMBL; AB168633; BAE00744.1; -; mRNA.
DR   RefSeq; NP_001270872.1; NM_001283943.1.
DR   AlphaFoldDB; Q4R828; -.
DR   SMR; Q4R828; -.
DR   STRING; 9541.XP_005595514.1; -.
DR   GeneID; 101864818; -.
DR   CTD; 91433; -.
DR   eggNOG; KOG1426; Eukaryota.
DR   OrthoDB; 1062377at2759; -.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.30; -; 1.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   Pfam; PF00415; RCC1; 3.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SUPFAM; SSF50985; SSF50985; 1.
DR   PROSITE; PS00626; RCC1_2; 2.
DR   PROSITE; PS50012; RCC1_3; 3.
PE   2: Evidence at transcript level;
KW   Chromatin regulator; Chromosome; Hydroxylation; Reference proteome; Repeat.
FT   CHAIN           1..376
FT                   /note="RCC1 domain-containing protein 1"
FT                   /id="PRO_0000337974"
FT   REPEAT          6..56
FT                   /note="RCC1 1"
FT   REPEAT          176..227
FT                   /note="RCC1 2"
FT   REPEAT          229..317
FT                   /note="RCC1 3"
FT   REPEAT          318..371
FT                   /note="RCC1 4"
FT   REGION          1..169
FT                   /note="Interaction with KDM8"
FT                   /evidence="ECO:0000250|UniProtKB:A6NED2"
FT   MOD_RES         141
FT                   /note="(3R)-3-hydroxyarginine"
FT                   /evidence="ECO:0000250|UniProtKB:A6NED2"
SQ   SEQUENCE   376 AA;  40162 MW;  C07C44C915FB58B0 CRC64;
     MAEERPGAWF GFGFCGFGQE LGSGRGHQVH SPSPLRAGVD VCRVSASWSY TAFVTRGGRV
     ELSGSASGAA GGCRDAWASE GLLLVLRAGP GPEALLQAWA PDSALRGEPL WAHSVVPEAV
     EEDDPGGEAQ IGRLPLLPCA RAYVSPRPPF YRPLAPELRA RQLELGAEHA LLLDAAGQVF
     SWGGGRHGQL GHGTLEAELE PRLLEALQGL TMAEVAAGGW HSVCVSETGD IYIWGWNESG
     QLALPTRNLA EDGETVAREA TGLNEDGSQV KRTGRVEDGA PAPFIAVQPF PALLDLPLGS
     DAVKVSCGSR HTAVVTRTGE LYTWGWGKYG QLGHEDTTSL DWPRRVEYFV DKQLQVKAVT
     CGPWNTYVYA VEKGKS