RCCD1_MOUSE
ID RCCD1_MOUSE Reviewed; 377 AA.
AC Q8BTU7; Q6IS64; Q8BJF2; Q8C0K3;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=RCC1 domain-containing protein 1;
GN Name=Rccd1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Eye, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N-3; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in transcriptional repression of satellite
CC repeats, possibly by regulating H3K36 methylation levels in centromeric
CC regions together with KDM8. Possibly together with KDM8, is involved in
CC proper mitotic spindle organization and chromosome segregation. Plays a
CC role in regulating alpha-tubulin deacetylation and cytoskeletal
CC microtubule stability, thereby promoting cell migration and TGF-beta-
CC induced epithelial to mesenchymal transition (EMT), potentially through
CC the inhibition of KDM8. {ECO:0000250|UniProtKB:A6NED2}.
CC -!- SUBUNIT: Found in a complex with KDM8. Interacts (via N-terminus) with
CC KDM8 (via N-terminus). {ECO:0000250|UniProtKB:A6NED2}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:A6NED2}.
CC Note=Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3).
CC {ECO:0000250|UniProtKB:A6NED2}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BTU7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BTU7-2; Sequence=VSP_034012;
CC -!- PTM: Specifically hydroxylated (with R stereochemistry) at C-3 of ARG-
CC 141 by KDM8. {ECO:0000250|UniProtKB:A6NED2}.
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DR EMBL; AK030872; BAC27167.1; -; mRNA.
DR EMBL; AK084219; BAC39142.1; -; mRNA.
DR EMBL; AK088662; BAC40487.1; -; mRNA.
DR EMBL; BC069844; AAH69844.1; -; mRNA.
DR CCDS; CCDS21394.1; -. [Q8BTU7-1]
DR RefSeq; NP_775621.2; NM_173445.4. [Q8BTU7-1]
DR RefSeq; XP_006540989.1; XM_006540926.2. [Q8BTU7-1]
DR RefSeq; XP_006540991.1; XM_006540928.2. [Q8BTU7-1]
DR RefSeq; XP_006540992.1; XM_006540929.2. [Q8BTU7-1]
DR RefSeq; XP_017177783.1; XM_017322294.1. [Q8BTU7-1]
DR AlphaFoldDB; Q8BTU7; -.
DR SMR; Q8BTU7; -.
DR STRING; 10090.ENSMUSP00000048043; -.
DR iPTMnet; Q8BTU7; -.
DR PhosphoSitePlus; Q8BTU7; -.
DR EPD; Q8BTU7; -.
DR MaxQB; Q8BTU7; -.
DR PaxDb; Q8BTU7; -.
DR PRIDE; Q8BTU7; -.
DR ProteomicsDB; 255054; -. [Q8BTU7-1]
DR ProteomicsDB; 255055; -. [Q8BTU7-2]
DR Antibodypedia; 50047; 23 antibodies from 9 providers.
DR DNASU; 269955; -.
DR Ensembl; ENSMUST00000047362; ENSMUSP00000048043; ENSMUSG00000038930. [Q8BTU7-1]
DR Ensembl; ENSMUST00000121882; ENSMUSP00000113273; ENSMUSG00000038930. [Q8BTU7-1]
DR GeneID; 269955; -.
DR KEGG; mmu:269955; -.
DR UCSC; uc009ial.2; mouse. [Q8BTU7-1]
DR CTD; 91433; -.
DR MGI; MGI:2444156; Rccd1.
DR VEuPathDB; HostDB:ENSMUSG00000038930; -.
DR eggNOG; KOG1426; Eukaryota.
DR GeneTree; ENSGT00940000162149; -.
DR HOGENOM; CLU_005210_2_1_1; -.
DR InParanoid; Q8BTU7; -.
DR OMA; KTVTCGP; -.
DR OrthoDB; 1062377at2759; -.
DR PhylomeDB; Q8BTU7; -.
DR TreeFam; TF329484; -.
DR BioGRID-ORCS; 269955; 0 hits in 72 CRISPR screens.
DR ChiTaRS; Rccd1; mouse.
DR PRO; PR:Q8BTU7; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BTU7; protein.
DR Bgee; ENSMUSG00000038930; Expressed in ureter smooth muscle and 192 other tissues.
DR ExpressionAtlas; Q8BTU7; baseline and differential.
DR Genevisible; Q8BTU7; MM.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.30; -; 1.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR Pfam; PF00415; RCC1; 3.
DR PRINTS; PR00633; RCCNDNSATION.
DR SUPFAM; SSF50985; SSF50985; 1.
DR PROSITE; PS00626; RCC1_2; 2.
DR PROSITE; PS50012; RCC1_3; 3.
PE 2: Evidence at transcript level;
KW Alternative splicing; Chromatin regulator; Chromosome; Hydroxylation;
KW Reference proteome; Repeat.
FT CHAIN 1..377
FT /note="RCC1 domain-containing protein 1"
FT /id="PRO_0000337975"
FT REPEAT 6..57
FT /note="RCC1 1"
FT REPEAT 179..230
FT /note="RCC1 2"
FT REPEAT 232..289
FT /note="RCC1 3"
FT REPEAT 319..372
FT /note="RCC1 4"
FT REGION 1..172
FT /note="Interaction with KDM8"
FT /evidence="ECO:0000250|UniProtKB:A6NED2"
FT MOD_RES 144
FT /note="(3R)-3-hydroxyarginine"
FT /evidence="ECO:0000250|UniProtKB:A6NED2"
FT VAR_SEQ 1..214
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_034012"
FT CONFLICT 18
FT /note="G -> R (in Ref. 1; BAC27167)"
FT /evidence="ECO:0000305"
FT CONFLICT 30
FT /note="V -> L (in Ref. 1; BAC39142/BAC40487)"
FT /evidence="ECO:0000305"
FT CONFLICT 93
FT /note="S -> A (in Ref. 2; AAH69844)"
FT /evidence="ECO:0000305"
FT CONFLICT 97
FT /note="V -> L (in Ref. 2; AAH69844)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="A -> T (in Ref. 2; AAH69844)"
FT /evidence="ECO:0000305"
FT CONFLICT 255
FT /note="N -> K (in Ref. 2; AAH69844)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="L -> V (in Ref. 1; BAC27167)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 377 AA; 40591 MW; C060C1DCC32A753D CRC64;
MAEKRHGAWF GFGFCGFGQA LGSGNSHHSV YSPEPLHASD DICQVSAGWS YTALVTRGGR
VELSGSVSGA ADGCRDVWAS EELLVLLRNK GGSSTEVQAW VPGSALQGEP LWVQNLVSGA
KGQGEDEPSR ESRMGTLPLL PCARAYVTPE PPFCQPLAPE LRVRQLELGA EHVLLLCAAG
QVFSWGAGRH GQLGHGTLEA ELEPRLLEAL QGLRMAKVAA GGWHSVCLSE TGDIYIWGWN
ESGQLALPTR SGTENKAERE EATELNEDGL KEELAVADAG APAHFIAIQP FPALLDLPLG
SDAVMASCGS RHTAVVTRTG ELYTWGWGKY GQLGHKDSTS LDRPCCVEYF VERQLEVRAV
TCGPWNTYVY AMERDKS
