ID   RCF1_NEUCR              Reviewed;         221 AA.
AC   Q7S455;
DT   05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT   23-OCT-2007, sequence version 2.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Respiratory supercomplex factor 1, mitochondrial;
GN   Name=rcf1; ORFNames=NCU02451;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Cytochrome c oxidase subunit which plays a role in assembly
CC       of respiratory supercomplexes. {ECO:0000250}.
CC   -!- SUBUNIT: Associates with the respiratory chain complex III/complex IV
CC       supercomplex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion membrane {ECO:0000255|PROSITE-
CC       ProRule:PRU00836}; Multi-pass membrane protein {ECO:0000255|PROSITE-
CC       ProRule:PRU00836}.
CC   -!- SIMILARITY: Belongs to the RCF1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAA30270.3; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; CM002242; EAA30270.3; ALT_INIT; Genomic_DNA.
DR   RefSeq; XP_959506.3; XM_954413.3.
DR   AlphaFoldDB; Q7S455; -.
DR   STRING; 5141.EFNCRP00000008507; -.
DR   PRIDE; Q7S455; -.
DR   EnsemblFungi; EAA30270; EAA30270; NCU02451.
DR   GeneID; 3875653; -.
DR   KEGG; ncr:NCU02451; -.
DR   HOGENOM; CLU_087356_0_1_1; -.
DR   InParanoid; Q7S455; -.
DR   OMA; SVEMNKM; -.
DR   Proteomes; UP000001805; Chromosome 7, Linkage Group VII.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0097250; P:mitochondrial respirasome assembly; IBA:GO_Central.
DR   InterPro; IPR007667; Hypoxia_induced_domain.
DR   Pfam; PF04588; HIG_1_N; 1.
DR   PROSITE; PS51503; HIG1; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Mitochondrion; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..221
FT                   /note="Respiratory supercomplex factor 1, mitochondrial"
FT                   /id="PRO_0000399642"
FT   TRANSMEM        46..68
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT   TRANSMEM        83..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT   DOMAIN          20..111
FT                   /note="HIG1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00836"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          112..151
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   221 AA;  24509 MW;  B0489AD75F060909 CRC64;
     MPNSTDNQGS APPGLSSRPL PSSFDDNADF YNENGFQKVS RRLREEPLIP IGCIATVAAF
     TGAYRAMRRG DHEQVQRMFR ARVAAQAFTV VAMVAGSWYY AADRQKQKEL WKLKEQQDAE
     EKRQKWIREL EVRDAEDKAL QERLEKRRKK KAERDSAAGA PDGVAAQAQA AYADAKEKVS
     SPAGDVAPED PNKSNITGVR ERLPTWLGGS KGADGSSRDK N