ID   RCL1_ARATH              Reviewed;         375 AA.
AC   Q9C578;
DT   01-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 132.
DE   RecName: Full=Probable RNA 3'-terminal phosphate cyclase-like protein;
GN   OrderedLocusNames=At5g22100; ORFNames=T6G21.20;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130714; DOI=10.1038/35048507;
RA   Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA   Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA   Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA   Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA   Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA   O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA   Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA   Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA   Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA   Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA   Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA   Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA   Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA   Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA   Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA   Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA   McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA   Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA   Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA   Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA   Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA   Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA   Bevan M., Fransz P.F.;
RT   "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL   Nature 408:823-826(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=14593172; DOI=10.1126/science.1088305;
RA   Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA   Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA   Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA   Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA   Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA   Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA   Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA   Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA   Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA   Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA   Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA   Ecker J.R.;
RT   "Empirical analysis of transcriptional activity in the Arabidopsis
RT   genome.";
RL   Science 302:842-846(2003).
CC   -!- FUNCTION: Does not have cyclase activity. Plays a role in 40S-
CC       ribosomal-subunit biogenesis in the early pre-rRNA processing steps at
CC       sites A0, A1 and A2 that are required for proper maturation of the 18S
CC       RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AL589883; CAC34503.1; -; Genomic_DNA.
DR   EMBL; CP002688; AED92983.1; -; Genomic_DNA.
DR   EMBL; BT002059; AAN72070.1; -; mRNA.
DR   RefSeq; NP_680196.1; NM_147891.4.
DR   AlphaFoldDB; Q9C578; -.
DR   SMR; Q9C578; -.
DR   BioGRID; 17546; 1.
DR   STRING; 3702.AT5G22100.1; -.
DR   PaxDb; Q9C578; -.
DR   PRIDE; Q9C578; -.
DR   ProteomicsDB; 236212; -.
DR   EnsemblPlants; AT5G22100.1; AT5G22100.1; AT5G22100.
DR   GeneID; 832271; -.
DR   Gramene; AT5G22100.1; AT5G22100.1; AT5G22100.
DR   KEGG; ath:AT5G22100; -.
DR   Araport; AT5G22100; -.
DR   TAIR; locus:504956443; AT5G22100.
DR   eggNOG; KOG3980; Eukaryota.
DR   HOGENOM; CLU_027882_1_1_1; -.
DR   OMA; GCLYSAD; -.
DR   OrthoDB; 1423847at2759; -.
DR   PhylomeDB; Q9C578; -.
DR   PRO; PR:Q9C578; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9C578; baseline and differential.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   CDD; cd00875; RNA_Cyclase_Class_I; 1.
DR   Gene3D; 3.30.360.20; -; 1.
DR   Gene3D; 3.65.10.20; -; 1.
DR   InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR   InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR   InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf.
DR   InterPro; IPR000228; RNA3'_term_phos_cyc.
DR   InterPro; IPR016443; RNA3'_term_phos_cyc_type_2.
DR   InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS.
DR   InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR   InterPro; IPR036553; RPTC_insert.
DR   PANTHER; PTHR11096; PTHR11096; 1.
DR   Pfam; PF01137; RTC; 1.
DR   Pfam; PF05189; RTC_insert; 1.
DR   SUPFAM; SSF55205; SSF55205; 1.
DR   TIGRFAMs; TIGR03400; 18S_RNA_Rcl1p; 1.
DR   PROSITE; PS01287; RTC; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..375
FT                   /note="Probable RNA 3'-terminal phosphate cyclase-like
FT                   protein"
FT                   /id="PRO_0000156442"
SQ   SEQUENCE   375 AA;  40874 MW;  3C7D286D4386D5AF CRC64;
     MVMMKKMKGS QSFRQRLLLS TLSSTPISID EIRADETIPG LRPHEVNLLR LLEIVTDDAV
     VDINETGTRL KYKPGTIVGG KNLVHSCSLS RSIGYYLEPL LLLGLFGKKP LSIRLKGITN
     DPRDASVDTF RSTTLNIIKR FGVPAEDLEL KIEARGVAPN GGGEVLLTVP NIKTLSAVHW
     VEEGMVKKIR GTTFSTRVTS DFEHSMRFAA RGIFNNLLPD VHIFQDHRAG AQAGKSPGYG
     ISLAAETTTG CFISADTTVS CERPDETGEL DVEKKERSPA EDTGVEVASW LLQEIEKGGV
     VDSTHQGLLF LLCALSEQDV SKVRVGTLSP YAVETLRNIK EFLGVKFAIK PDPLTGTVIL
     KCTGSGLINL SRKLS