ID   RCL1_BOVIN              Reviewed;         373 AA.
AC   Q2KHX8;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=RNA 3'-terminal phosphate cyclase-like protein;
GN   Name=RCL1;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Hypothalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JAN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Does not have cyclase activity. Plays a role in 40S-
CC       ribosomal-subunit biogenesis in the early pre-rRNA processing steps at
CC       sites A0, A1 and A2 that are required for proper maturation of the 18S
CC       RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; BC112844; AAI12845.1; -; mRNA.
DR   RefSeq; NP_001070599.1; NM_001077131.1.
DR   AlphaFoldDB; Q2KHX8; -.
DR   SMR; Q2KHX8; -.
DR   STRING; 9913.ENSBTAP00000024840; -.
DR   PaxDb; Q2KHX8; -.
DR   PRIDE; Q2KHX8; -.
DR   Ensembl; ENSBTAT00000024840; ENSBTAP00000024840; ENSBTAG00000018667.
DR   GeneID; 768075; -.
DR   KEGG; bta:768075; -.
DR   CTD; 10171; -.
DR   VEuPathDB; HostDB:ENSBTAG00000018667; -.
DR   VGNC; VGNC:33830; RCL1.
DR   eggNOG; KOG3980; Eukaryota.
DR   GeneTree; ENSGT00730000111185; -.
DR   HOGENOM; CLU_027882_1_0_1; -.
DR   InParanoid; Q2KHX8; -.
DR   OMA; GCLYSAD; -.
DR   OrthoDB; 1423847at2759; -.
DR   TreeFam; TF300831; -.
DR   Proteomes; UP000009136; Chromosome 8.
DR   Bgee; ENSBTAG00000018667; Expressed in liver and 106 other tissues.
DR   ExpressionAtlas; Q2KHX8; baseline and differential.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   CDD; cd00875; RNA_Cyclase_Class_I; 1.
DR   Gene3D; 3.30.360.20; -; 1.
DR   Gene3D; 3.65.10.20; -; 1.
DR   InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR   InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR   InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf.
DR   InterPro; IPR000228; RNA3'_term_phos_cyc.
DR   InterPro; IPR016443; RNA3'_term_phos_cyc_type_2.
DR   InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS.
DR   InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR   InterPro; IPR036553; RPTC_insert.
DR   PANTHER; PTHR11096; PTHR11096; 1.
DR   PANTHER; PTHR11096:SF1; PTHR11096:SF1; 1.
DR   Pfam; PF01137; RTC; 1.
DR   Pfam; PF05189; RTC_insert; 1.
DR   PIRSF; PIRSF005378; RNA3'_term_phos_cycl_euk; 1.
DR   SUPFAM; SSF55205; SSF55205; 1.
DR   TIGRFAMs; TIGR03400; 18S_RNA_Rcl1p; 1.
DR   PROSITE; PS01287; RTC; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..373
FT                   /note="RNA 3'-terminal phosphate cyclase-like protein"
FT                   /id="PRO_0000288840"
SQ   SEQUENCE   373 AA;  41010 MW;  303BCDC0956576E8 CRC64;
     MASQAHSLSY SGCNFLRQRL VLSTLSGRPV KIRKIRARDD NPGLRDFEAS FIRLLDKVTN
     GSRIEINQTG TTLYYQPGLL YGGSMEHDCS VLRGIGYYLE SLLCLAPFMK HPLRIVLRGV
     TNDQVDPSVD VLKATALPLL KQFGIDGESF ELKVVRRGMP PGGGGEVFFS CPVRKVLKPI
     QLIDPGKIKR IRGMAYSVRV SPQMANRIVD SARSILNKFI PDIYIYTDHM KGINSGKSPG
     FGLSLVAETT NGTFLSAELA SNPQGQGAAM LPEDLGRNCA RLLLEEIYRG GCVDSTNQSL
     ALLLMTLGQQ DVSKVLLGPL SPYTIEFLRH LKSFFQIMFK IETKPCGEEL KGGDKVLMTC
     VGIGFSNLSK TLK