ID   RCL1_CAEEL              Reviewed;         379 AA.
AC   Q23400;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 2.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=Probable RNA 3'-terminal phosphate cyclase-like protein;
GN   ORFNames=ZK1127.5;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=9184239; DOI=10.1093/emboj/16.10.2955;
RA   Genschik P., Billy E., Swianiewicz M., Filipowicz W.;
RT   "The human RNA 3'-terminal phosphate cyclase is a member of a new family of
RT   proteins conserved in Eucarya, Bacteria and Archaea.";
RL   EMBO J. 16:2955-2967(1997).
CC   -!- FUNCTION: Does not have cyclase activity. Plays a role in 40S-
CC       ribosomal-subunit biogenesis in the early pre-rRNA processing steps at
CC       sites A0, A1 and A2 that are required for proper maturation of the 18S
CC       RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 2
CC       subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; FO081697; CCD73717.1; -; Genomic_DNA.
DR   PIR; G88196; G88196.
DR   RefSeq; NP_495445.2; NM_063044.5.
DR   AlphaFoldDB; Q23400; -.
DR   SMR; Q23400; -.
DR   BioGRID; 39488; 1.
DR   STRING; 6239.ZK1127.5; -.
DR   EPD; Q23400; -.
DR   PaxDb; Q23400; -.
DR   PeptideAtlas; Q23400; -.
DR   EnsemblMetazoa; ZK1127.5.1; ZK1127.5.1; WBGene00022852.
DR   GeneID; 174151; -.
DR   KEGG; cel:CELE_ZK1127.5; -.
DR   UCSC; ZK1127.5; c. elegans.
DR   CTD; 174151; -.
DR   WormBase; ZK1127.5; CE32083; WBGene00022852; -.
DR   eggNOG; KOG3980; Eukaryota.
DR   GeneTree; ENSGT00530000063404; -.
DR   HOGENOM; CLU_027882_1_0_1; -.
DR   InParanoid; Q23400; -.
DR   OMA; GCLYSAD; -.
DR   OrthoDB; 1423847at2759; -.
DR   PhylomeDB; Q23400; -.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q23400; -.
DR   Proteomes; UP000001940; Chromosome II.
DR   Bgee; WBGene00022852; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   CDD; cd00875; RNA_Cyclase_Class_I; 1.
DR   Gene3D; 3.30.360.20; -; 1.
DR   Gene3D; 3.65.10.20; -; 1.
DR   InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR   InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR   InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf.
DR   InterPro; IPR000228; RNA3'_term_phos_cyc.
DR   InterPro; IPR016443; RNA3'_term_phos_cyc_type_2.
DR   InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS.
DR   InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR   InterPro; IPR036553; RPTC_insert.
DR   PANTHER; PTHR11096; PTHR11096; 1.
DR   PANTHER; PTHR11096:SF1; PTHR11096:SF1; 1.
DR   Pfam; PF01137; RTC; 1.
DR   Pfam; PF05189; RTC_insert; 1.
DR   PIRSF; PIRSF005378; RNA3'_term_phos_cycl_euk; 1.
DR   SUPFAM; SSF55205; SSF55205; 1.
DR   TIGRFAMs; TIGR03400; 18S_RNA_Rcl1p; 1.
DR   PROSITE; PS01287; RTC; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..379
FT                   /note="Probable RNA 3'-terminal phosphate cyclase-like
FT                   protein"
FT                   /id="PRO_0000156441"
SQ   SEQUENCE   379 AA;  41597 MW;  A6AAE4C90EA1D516 CRC64;
     MSSETLEFSG CNFFRIRLAY SILSGRPIRI INIRKNDDRP GIRDFESKLI GLLEKVTNGT
     KVEISRTGTQ VIFRPGMITG GVVNLDCGTE RCISYFLEPL LLLSPFCKVP MVIKLKGVTN
     APGEISVDGM KASWLKVYNK FVLNDEKLDI KIQARGLKPE GGGVVVFTAP IVKTLRPVKR
     QQVGKVCKIR GQAYVTKVTP SLAYRMIDAA KKAMHGYISD VYITVDQRKG DAGGASPGYG
     LFLTAETTEG VIYQAEAISR PKGESGVPIL PEDIGIEAGH ALLQQIYMGG ALDSSAQILA
     STFMTLCPKD VSHFLYGPLP MYSVHALRHL KQFFEIEFKM EDFKKTLKEE EADLKTGSAD
     KAMVTAVGVG YSNLNKTIL