ID   RCL1_DICDI              Reviewed;         371 AA.
AC   Q54S38;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 102.
DE   RecName: Full=Probable RNA 3'-terminal phosphate cyclase-like protein;
GN   Name=rcl1; ORFNames=DDB_G0282803;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=AX2;
RX   PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA   Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA   Soldati T.;
RT   "Proteomics fingerprinting of phagosome maturation and evidence for the
RT   role of a Galpha during uptake.";
RL   Mol. Cell. Proteomics 5:2228-2243(2006).
CC   -!- FUNCTION: Does not have cyclase activity. Plays a role in 40S-
CC       ribosomal-subunit biogenesis in the early pre-rRNA processing steps at
CC       sites A0, A1 and A2 that are required for proper maturation of the 18S
CC       RNA (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 2
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AAFI02000047; EAL66261.2; -; Genomic_DNA.
DR   RefSeq; XP_640201.2; XM_635109.2.
DR   AlphaFoldDB; Q54S38; -.
DR   SMR; Q54S38; -.
DR   STRING; 44689.DDB0238227; -.
DR   PaxDb; Q54S38; -.
DR   EnsemblProtists; EAL66261; EAL66261; DDB_G0282803.
DR   GeneID; 8623741; -.
DR   KEGG; ddi:DDB_G0282803; -.
DR   dictyBase; DDB_G0282803; rcl1.
DR   eggNOG; KOG3980; Eukaryota.
DR   HOGENOM; CLU_027882_1_0_1; -.
DR   InParanoid; Q54S38; -.
DR   OMA; GCLYSAD; -.
DR   PhylomeDB; Q54S38; -.
DR   Reactome; R-DDI-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   PRO; PR:Q54S38; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR   GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR   GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   CDD; cd00875; RNA_Cyclase_Class_I; 1.
DR   Gene3D; 3.30.360.20; -; 1.
DR   Gene3D; 3.65.10.20; -; 1.
DR   InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR   InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR   InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf.
DR   InterPro; IPR000228; RNA3'_term_phos_cyc.
DR   InterPro; IPR016443; RNA3'_term_phos_cyc_type_2.
DR   InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS.
DR   InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR   InterPro; IPR036553; RPTC_insert.
DR   PANTHER; PTHR11096; PTHR11096; 1.
DR   PANTHER; PTHR11096:SF1; PTHR11096:SF1; 1.
DR   Pfam; PF01137; RTC; 1.
DR   Pfam; PF05189; RTC_insert; 1.
DR   PIRSF; PIRSF005378; RNA3'_term_phos_cycl_euk; 1.
DR   SUPFAM; SSF55205; SSF55205; 1.
DR   TIGRFAMs; TIGR03400; 18S_RNA_Rcl1p; 1.
DR   PROSITE; PS01287; RTC; 1.
PE   1: Evidence at protein level;
KW   Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..371
FT                   /note="Probable RNA 3'-terminal phosphate cyclase-like
FT                   protein"
FT                   /id="PRO_0000330338"
SQ   SEQUENCE   371 AA;  40810 MW;  C13CC1CFEA14D15E CRC64;
     MLKFQGSTHF RQRIICSTLS GKAIRITNIR DEDEKPGLRD YEASFLRLVD KITNGSKIEI
     NSTGTQITYI PGIIIGGKGI THECGTVRGI GYFVEALICL GPFAKAPLDI TLNGITNNDI
     DLTIDTIRTT TLPIIRKFGI EEGLIIKIIK RGAPPNGGGS VNFKCPIVPH LKAIQLIDEG
     KIRRIRGIAY ATRISPQFSN RVLDKAKGLL LEYTPDVYIS SDHYKGNESG LSPGYGLTLV
     AETTTGCCLS AECMSNTGIA TTEQQLQKQK STSETPEDLG ERTAFALLEE IFNGGCIDSH
     NQSLALLFMV LCPEDISKVR LGKITPYTIE FIRQLRDFFG VTFKIEPDQN SKTVLFTCLG
     IGYKNMARST F