RCL1_DROME
ID RCL1_DROME Reviewed; 384 AA.
AC P56175; Q95TH8; Q9VY90;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 02-FEB-2004, sequence version 3.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Probable RNA 3'-terminal phosphate cyclase-like protein;
GN Name=Rtc1; Synonyms=RCL1, RTC2; ORFNames=CG11130;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-384.
RX PubMed=3029679; DOI=10.1093/nar/15.1.67;
RA Yan Y.L., Kunert C.J., Postlethwait J.H.;
RT "Sequence homologies among the three yolk polypeptide (Yp) genes in
RT Drosophila melanogaster.";
RL Nucleic Acids Res. 15:67-85(1987).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 150-384.
RX PubMed=3114046; DOI=10.1016/0378-1119(87)90242-3;
RA Garabedian M.J., Shirras A.D., Bownes M., Wensink P.C.;
RT "The nucleotide sequence of the gene coding for Drosophila melanogaster
RT yolk protein 3.";
RL Gene 55:1-8(1987).
RN [6]
RP IDENTIFICATION.
RX PubMed=9184239; DOI=10.1093/emboj/16.10.2955;
RA Genschik P., Billy E., Swianiewicz M., Filipowicz W.;
RT "The human RNA 3'-terminal phosphate cyclase is a member of a new family of
RT proteins conserved in Eucarya, Bacteria and Archaea.";
RL EMBO J. 16:2955-2967(1997).
CC -!- FUNCTION: Does not have cyclase activity. Plays a role in 40S-
CC ribosomal-subunit biogenesis in the early pre-rRNA processing steps at
CC sites A0, A1 and A2 that are required for proper maturation of the 18S
CC RNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 2
CC subfamily. {ECO:0000305}.
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DR EMBL; AE014298; AAF48313.2; -; Genomic_DNA.
DR EMBL; AY058762; AAL13991.1; -; mRNA.
DR EMBL; X04754; CAB55765.1; -; Genomic_DNA.
DR EMBL; M15898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_572919.1; NM_132691.4.
DR AlphaFoldDB; P56175; -.
DR SMR; P56175; -.
DR BioGRID; 58711; 2.
DR STRING; 7227.FBpp0073651; -.
DR PaxDb; P56175; -.
DR PRIDE; P56175; -.
DR DNASU; 32338; -.
DR EnsemblMetazoa; FBtr0073820; FBpp0073651; FBgn0020909.
DR GeneID; 32338; -.
DR KEGG; dme:Dmel_CG11130; -.
DR UCSC; CG11130-RA; d. melanogaster.
DR CTD; 32338; -.
DR FlyBase; FBgn0020909; Rtc1.
DR VEuPathDB; VectorBase:FBgn0020909; -.
DR eggNOG; KOG3980; Eukaryota.
DR GeneTree; ENSGT00530000063404; -.
DR HOGENOM; CLU_027882_1_0_1; -.
DR InParanoid; P56175; -.
DR OMA; GCLYSAD; -.
DR OrthoDB; 1423847at2759; -.
DR PhylomeDB; P56175; -.
DR Reactome; R-DME-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 32338; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 32338; -.
DR PRO; PR:P56175; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0020909; Expressed in secondary oocyte and 23 other tissues.
DR Genevisible; P56175; DM.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR CDD; cd00875; RNA_Cyclase_Class_I; 1.
DR Gene3D; 3.30.360.20; -; 1.
DR Gene3D; 3.65.10.20; -; 1.
DR InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf.
DR InterPro; IPR000228; RNA3'_term_phos_cyc.
DR InterPro; IPR016443; RNA3'_term_phos_cyc_type_2.
DR InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS.
DR InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR InterPro; IPR036553; RPTC_insert.
DR PANTHER; PTHR11096; PTHR11096; 1.
DR PANTHER; PTHR11096:SF1; PTHR11096:SF1; 1.
DR Pfam; PF01137; RTC; 1.
DR Pfam; PF05189; RTC_insert; 1.
DR PIRSF; PIRSF005378; RNA3'_term_phos_cycl_euk; 1.
DR SUPFAM; SSF55205; SSF55205; 1.
DR TIGRFAMs; TIGR03400; 18S_RNA_Rcl1p; 1.
DR PROSITE; PS01287; RTC; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..384
FT /note="Probable RNA 3'-terminal phosphate cyclase-like
FT protein"
FT /id="PRO_0000156440"
FT CONFLICT 165..168
FT /note="PLGG -> SAGR (in Ref. 5; M15898)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 384 AA; 42091 MW; 2B1E35D144C1CFAE CRC64;
MPPIAQEGNC LIYRGSNFLK QRLILACLSG KPVKISQIRS EDETAPGLRE YEISLIRLLD
KITNGTKIEL NPAGTSVMFS PGLLHGGQLN HDCCVQRGIG YYLDALIALG PFCKSPLQCT
LRGVTNSKDS PSVDHIKGAA LSLLKRFLLV DEGLELKVVR RGVAPLGGGE IIFRCPVRKS
LRAIQFQSQG MVKRIRGTVY ACKVSPAMAN RTVEAAKGCM LKFLPDVYIY TDQNKGKMSG
NSPGFGICLI AETTDGVCFA ADCCSNTREE SEDTPSIPEN LGKEVALRLL DEIYRGGCVD
SSYQWLAALY IALGQKHVSK FLTGALSNYT VHFLQHLRDF FSITFKLENP EAEDEDEAEN
VRGAQKVLMA CVGIGYTNIN KRVI
