RCL1_MOUSE
ID RCL1_MOUSE Reviewed; 373 AA.
AC Q9JJT0;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=RNA 3'-terminal phosphate cyclase-like protein;
GN Name=Rcl1; Synonyms=Rnac;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10790377; DOI=10.1093/emboj/19.9.2115;
RA Billy E., Wegierski T., Nasr F., Filipowicz W.;
RT "Rcl1p, the yeast protein similar to the RNA 3'-phosphate cyclase,
RT associates with U3 snoRNP and is required for 18S rRNA biogenesis.";
RL EMBO J. 19:2115-2126(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II; TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Does not have cyclase activity. Plays a role in 40S-
CC ribosomal-subunit biogenesis in the early pre-rRNA processing steps at
CC sites A0, A1 and A2 that are required for proper maturation of the 18S
CC RNA (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the RNA 3'-terminal cyclase family. Type 2
CC subfamily. {ECO:0000305}.
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DR EMBL; AJ276895; CAB89817.1; -; mRNA.
DR EMBL; AK009709; BAB26454.1; -; mRNA.
DR EMBL; BC004574; AAH04574.1; -; mRNA.
DR CCDS; CCDS29731.1; -.
DR RefSeq; NP_067500.1; NM_021525.2.
DR AlphaFoldDB; Q9JJT0; -.
DR SMR; Q9JJT0; -.
DR BioGRID; 208495; 16.
DR STRING; 10090.ENSMUSP00000067579; -.
DR iPTMnet; Q9JJT0; -.
DR PhosphoSitePlus; Q9JJT0; -.
DR EPD; Q9JJT0; -.
DR MaxQB; Q9JJT0; -.
DR PaxDb; Q9JJT0; -.
DR PeptideAtlas; Q9JJT0; -.
DR PRIDE; Q9JJT0; -.
DR ProteomicsDB; 300325; -.
DR Antibodypedia; 24072; 158 antibodies from 25 providers.
DR DNASU; 59028; -.
DR Ensembl; ENSMUST00000064393; ENSMUSP00000067579; ENSMUSG00000024785.
DR GeneID; 59028; -.
DR KEGG; mmu:59028; -.
DR UCSC; uc008hda.1; mouse.
DR CTD; 10171; -.
DR MGI; MGI:1913275; Rcl1.
DR VEuPathDB; HostDB:ENSMUSG00000024785; -.
DR eggNOG; KOG3980; Eukaryota.
DR GeneTree; ENSGT00530000063404; -.
DR HOGENOM; CLU_027882_1_0_1; -.
DR InParanoid; Q9JJT0; -.
DR OMA; GCLYSAD; -.
DR OrthoDB; 1423847at2759; -.
DR PhylomeDB; Q9JJT0; -.
DR TreeFam; TF300831; -.
DR Reactome; R-MMU-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR BioGRID-ORCS; 59028; 27 hits in 73 CRISPR screens.
DR ChiTaRS; Rcl1; mouse.
DR PRO; PR:Q9JJT0; -.
DR Proteomes; UP000000589; Chromosome 19.
DR RNAct; Q9JJT0; protein.
DR Bgee; ENSMUSG00000024785; Expressed in left lobe of liver and 251 other tissues.
DR ExpressionAtlas; Q9JJT0; baseline and differential.
DR Genevisible; Q9JJT0; MM.
DR GO; GO:0005730; C:nucleolus; IDA:MGI.
DR GO; GO:0004521; F:endoribonuclease activity; IBA:GO_Central.
DR GO; GO:0000480; P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:MGI.
DR GO; GO:0000447; P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IMP:MGI.
DR GO; GO:0000479; P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR GO; GO:0006364; P:rRNA processing; ISA:MGI.
DR CDD; cd00875; RNA_Cyclase_Class_I; 1.
DR Gene3D; 3.30.360.20; -; 1.
DR Gene3D; 3.65.10.20; -; 1.
DR InterPro; IPR013791; RNA3'-term_phos_cycl_insert.
DR InterPro; IPR023797; RNA3'_phos_cyclase_dom.
DR InterPro; IPR037136; RNA3'_phos_cyclase_dom_sf.
DR InterPro; IPR000228; RNA3'_term_phos_cyc.
DR InterPro; IPR016443; RNA3'_term_phos_cyc_type_2.
DR InterPro; IPR020719; RNA3'_term_phos_cycl-like_CS.
DR InterPro; IPR013792; RNA3'P_cycl/enolpyr_Trfase_a/b.
DR InterPro; IPR036553; RPTC_insert.
DR PANTHER; PTHR11096; PTHR11096; 1.
DR PANTHER; PTHR11096:SF1; PTHR11096:SF1; 1.
DR Pfam; PF01137; RTC; 1.
DR Pfam; PF05189; RTC_insert; 1.
DR PIRSF; PIRSF005378; RNA3'_term_phos_cycl_euk; 1.
DR SUPFAM; SSF55205; SSF55205; 1.
DR TIGRFAMs; TIGR03400; 18S_RNA_Rcl1p; 1.
DR PROSITE; PS01287; RTC; 1.
PE 2: Evidence at transcript level;
KW Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..373
FT /note="RNA 3'-terminal phosphate cyclase-like protein"
FT /id="PRO_0000156439"
SQ SEQUENCE 373 AA; 40841 MW; 3BE97CA47A8CEFA1 CRC64;
MATQAHSLSY AGCNFLRQRL VLSTLSGRPV KIRRIRARDD NPGLRDFEAS FIRLLDKITN
GSRIEINQTG TTLYYQPGLL YGGSVEHDCS VLRGIGYYLE ALLCLAPFMK HPLKIVLRGV
TNDQVDPSVD VLKATALPLL KQFGIDGESF ELKILRRGMP PGGGGEVLFS CPVRKVLKPV
QLTDPGKIKR IRGMAYSVRV SPQMANRIVD SARSILNKFI PDIYIYTDHM KGVSSGKSPG
FGLSLVAETT NGTFLSAELA SNPQGQGAAV LPEDLGRNCA KLLLEEIYRG GCVDSTNQSL
VLLLMTLGQQ DVSKVLLGPL SPYTIEFLRH LKSFFQVMFK VETKPCGEEL KGGDKVLMTC
VGIGFSNLSK TLK
