ID   RCLB_ECOLI              Reviewed;          78 AA.
AC   P75687; P71304; Q2MCB9;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2000, sequence version 2.
DT   03-AUG-2022, entry version 125.
DE   RecName: Full=Uncharacterized protein RclB;
DE   AltName: Full=Reactive chlorine resistance protein B;
DE   Flags: Precursor;
GN   Name=rclB; Synonyms=ykgI; OrderedLocusNames=b0303, JW5039;
OS   Escherichia coli (strain K12).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=83333;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RA   Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA   Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA   Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT   "Sequence of minutes 4-25 of Escherichia coli.";
RL   Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA   Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA   Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA   Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA   Shao Y.;
RT   "The complete genome sequence of Escherichia coli K-12.";
RL   Science 277:1453-1462(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX   PubMed=16738553; DOI=10.1038/msb4100049;
RA   Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA   Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT   "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT   and W3110.";
RL   Mol. Syst. Biol. 2:E1-E5(2006).
RN   [4]
RP   FUNCTION, INDUCTION, DISRUPTION PHENOTYPE, AND GENE NAME.
RC   STRAIN=K12 / MG1655 / ATCC 47076;
RX   PubMed=24078635; DOI=10.1074/jbc.m113.503516;
RA   Parker B.W., Schwessinger E.A., Jakob U., Gray M.J.;
RT   "The RclR protein is a reactive chlorine-specific transcription factor in
RT   Escherichia coli.";
RL   J. Biol. Chem. 288:32574-32584(2013).
CC   -!- FUNCTION: Probably involved in reactive chlorine species (RCS) stress
CC       resistance. {ECO:0000269|PubMed:24078635}.
CC   -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000305}.
CC   -!- INDUCTION: Induced by RclR in response to hypochlorous acid (HOCl).
CC       {ECO:0000269|PubMed:24078635}.
CC   -!- DISRUPTION PHENOTYPE: Mutants are more sensitive to HOCl treatment than
CC       wild-type cells. {ECO:0000269|PubMed:24078635}.
CC   -!- SIMILARITY: Belongs to the BhsA/McbA family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAB18030.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; U73857; AAB18030.1; ALT_INIT; Genomic_DNA.
DR   EMBL; U00096; AAC73406.2; -; Genomic_DNA.
DR   EMBL; AP009048; BAE76087.1; -; Genomic_DNA.
DR   PIR; G64756; G64756.
DR   RefSeq; NP_414837.2; NC_000913.3.
DR   RefSeq; WP_000474084.1; NZ_SSZK01000048.1.
DR   AlphaFoldDB; P75687; -.
DR   SMR; P75687; -.
DR   BioGRID; 4259799; 13.
DR   STRING; 511145.b0303; -.
DR   PaxDb; P75687; -.
DR   EnsemblBacteria; AAC73406; AAC73406; b0303.
DR   EnsemblBacteria; BAE76087; BAE76087; BAE76087.
DR   GeneID; 945658; -.
DR   KEGG; ecj:JW5039; -.
DR   KEGG; eco:b0303; -.
DR   PATRIC; fig|511145.12.peg.310; -.
DR   EchoBASE; EB4026; -.
DR   eggNOG; ENOG50338ZN; Bacteria.
DR   HOGENOM; CLU_2616581_0_0_6; -.
DR   OMA; YMFKKPV; -.
DR   PhylomeDB; P75687; -.
DR   BioCyc; EcoCyc:G6173-MON; -.
DR   PRO; PR:P75687; -.
DR   Proteomes; UP000000318; Chromosome.
DR   Proteomes; UP000000625; Chromosome.
DR   GO; GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
DR   GO; GO:1901530; P:response to hypochlorite; IMP:EcoCyc.
DR   Gene3D; 3.30.1660.10; -; 1.
DR   InterPro; IPR025543; Dodecin-like.
DR   InterPro; IPR036275; YdgH-like_sf.
DR   InterPro; IPR010854; YdgH/BhsA/McbA-like_dom.
DR   Pfam; PF07338; DUF1471; 1.
DR   SUPFAM; SSF159871; SSF159871; 1.
PE   2: Evidence at transcript level;
KW   Periplasm; Reference proteome; Signal; Stress response.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..78
FT                   /note="Uncharacterized protein RclB"
FT                   /id="PRO_0000013791"
SQ   SEQUENCE   78 AA;  8472 MW;  311EC9CEB79EECE8 CRC64;
     MFKKSVLFAT LLSGVMAFST NADDKIILKH ISVSSVSASP TVLEDTIADI ARKYNASSWK
     VTSMRIDNNS TATAVLYK