RCLC_ECOLI
ID RCLC_ECOLI Reviewed; 197 AA.
AC P75685; P71303; Q2MCC0;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 2.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Inner membrane protein RclC;
DE AltName: Full=Reactive chlorine resistance protein C;
GN Name=rclC; Synonyms=ykgB; OrderedLocusNames=b0301, JW5038;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RA Chung E., Allen E., Araujo R., Aparicio A.M., Davis K., Duncan M.,
RA Federspiel N., Hyman R., Kalman S., Komp C., Kurdi O., Lew H., Lin D.,
RA Namath A., Oefner P., Roberts D., Schramm S., Davis R.W.;
RT "Sequence of minutes 4-25 of Escherichia coli.";
RL Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS], AND SUBCELLULAR LOCATION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15919996; DOI=10.1126/science.1109730;
RA Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
RT "Global topology analysis of the Escherichia coli inner membrane
RT proteome.";
RL Science 308:1321-1323(2005).
RN [5]
RP FUNCTION, INDUCTION, DISRUPTION PHENOTYPE, AND GENE NAME.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=24078635; DOI=10.1074/jbc.m113.503516;
RA Parker B.W., Schwessinger E.A., Jakob U., Gray M.J.;
RT "The RclR protein is a reactive chlorine-specific transcription factor in
RT Escherichia coli.";
RL J. Biol. Chem. 288:32574-32584(2013).
CC -!- FUNCTION: Probably involved in reactive chlorine species (RCS) stress
CC resistance. {ECO:0000269|PubMed:24078635}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000269|PubMed:15919996}; Multi-pass membrane protein
CC {ECO:0000269|PubMed:15919996}.
CC -!- INDUCTION: Induced by RclR in response to hypochlorous acid (HOCl).
CC {ECO:0000269|PubMed:24078635}.
CC -!- DISRUPTION PHENOTYPE: Mutants are more sensitive to HOCl treatment than
CC wild-type cells. {ECO:0000269|PubMed:24078635}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB18029.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; U73857; AAB18029.1; ALT_FRAME; Genomic_DNA.
DR EMBL; U00096; AAC73404.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE76086.1; -; Genomic_DNA.
DR PIR; E64756; E64756.
DR RefSeq; NP_414835.2; NC_000913.3.
DR RefSeq; WP_001299021.1; NZ_SSZK01000048.1.
DR AlphaFoldDB; P75685; -.
DR BioGRID; 4259798; 5.
DR STRING; 511145.b0301; -.
DR PaxDb; P75685; -.
DR PRIDE; P75685; -.
DR EnsemblBacteria; AAC73404; AAC73404; b0301.
DR EnsemblBacteria; BAE76086; BAE76086; BAE76086.
DR GeneID; 66671403; -.
DR GeneID; 944974; -.
DR KEGG; ecj:JW5038; -.
DR KEGG; eco:b0301; -.
DR PATRIC; fig|511145.12.peg.309; -.
DR EchoBASE; EB3349; -.
DR eggNOG; COG3059; Bacteria.
DR HOGENOM; CLU_102847_0_0_6; -.
DR InParanoid; P75685; -.
DR OMA; FWNYEAE; -.
DR PhylomeDB; P75685; -.
DR BioCyc; EcoCyc:G6171-MON; -.
DR PRO; PR:P75685; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
DR GO; GO:1901530; P:response to hypochlorite; IMP:EcoCyc.
DR InterPro; IPR016865; RclC.
DR InterPro; IPR007339; RclC-like.
DR PANTHER; PTHR40106; PTHR40106; 1.
DR Pfam; PF04224; DUF417; 1.
DR PIRSF; PIRSF028065; UCP028065; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Stress response; Transmembrane; Transmembrane helix.
FT CHAIN 1..197
FT /note="Inner membrane protein RclC"
FT /id="PRO_0000168566"
FT TOPO_DOM 1..15
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 37..85
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..112
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..133
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 134..197
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 197 AA; 21899 MW; FC45E94197045C5E CRC64;
MEKYLHLLSR GDKIGLTLIR LSIAIVFMWI GLLKFVPYEA DSITPFVANS PLMSFFYEHP
EDYKQYLTHE GEYKPEARAW QTANNTYGFS NGLGVVEVII ALLVLANPVN RWLGLLGGLM
AFTTPLVTLS FLITTPEAWV PALGDAHHGF PYLSGAGRLV LKDTLMLAGA VMIMADSARE
ILKQRSNESS STLKTEY
