RCN1_YEAST
ID RCN1_YEAST Reviewed; 211 AA.
AC P36054; D6VX40;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Calcipressin-like protein;
DE AltName: Full=Down syndrome candidate region 1-like protein;
DE AltName: Full=Regulator of calcineurin 1;
GN Name=RCN1; Synonyms=DSCR1L; OrderedLocusNames=YKL159C; ORFNames=YKL613;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CG1945;
RX PubMed=10756093; DOI=10.1006/geno.2000.6127;
RA Strippoli P., Lenzi L., Petrini M., Carinci P., Zannotti M.;
RT "A new gene family including DSCR1 (Down syndrome candidate region 1) and
RT ZAKI-4: characterization from yeast to human and identification of DSCR1-
RT like 2, a novel human member (DSCR1L2).";
RL Genomics 64:252-263(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8091859; DOI=10.1002/yea.320100005;
RA Vandenbol M., Bolle P.-A., Dion C., Portetelle D., Hilger F.;
RT "DNA sequencing of a 36.2 kb fragment located between the FAS1 and LAP loci
RT of chromosome XI of Saccharomyces cerevisiae.";
RL Yeast 10:S35-S40(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP CHARACTERIZATION.
RX PubMed=10887154;
RA Kingsbury T.J., Cunningham K.W.;
RT "A conserved family of calcineurin regulators.";
RL Genes Dev. 14:1595-1604(2000).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-117, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=18407956; DOI=10.1074/mcp.m700468-mcp200;
RA Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.;
RT "A multidimensional chromatography technology for in-depth phosphoproteome
RT analysis.";
RL Mol. Cell. Proteomics 7:1389-1396(2008).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-113; SER-117 AND THR-182, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19779198; DOI=10.1126/science.1172867;
RA Holt L.J., Tuch B.B., Villen J., Johnson A.D., Gygi S.P., Morgan D.O.;
RT "Global analysis of Cdk1 substrate phosphorylation sites provides insights
RT into evolution.";
RL Science 325:1682-1686(2009).
CC -!- FUNCTION: Inhibits calcineurin-dependent transcriptional responses by
CC binding to the catalytic domain of calcineurin.
CC -!- INTERACTION:
CC P36054; P07834: CDC4; NbExp=4; IntAct=EBI-14898, EBI-4434;
CC -!- MISCELLANEOUS: Present with 521 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the RCAN family. {ECO:0000305}.
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DR EMBL; AF174139; AAF01680.1; -; mRNA.
DR EMBL; Z26877; CAA81495.1; -; Genomic_DNA.
DR EMBL; Z28159; CAA82001.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09006.1; -; Genomic_DNA.
DR PIR; S37792; S37792.
DR RefSeq; NP_012763.1; NM_001179725.1.
DR AlphaFoldDB; P36054; -.
DR BioGRID; 33979; 71.
DR DIP; DIP-7429N; -.
DR ELM; P36054; -.
DR IntAct; P36054; 7.
DR MINT; P36054; -.
DR STRING; 4932.YKL159C; -.
DR iPTMnet; P36054; -.
DR MaxQB; P36054; -.
DR PaxDb; P36054; -.
DR PRIDE; P36054; -.
DR EnsemblFungi; YKL159C_mRNA; YKL159C; YKL159C.
DR GeneID; 853698; -.
DR KEGG; sce:YKL159C; -.
DR SGD; S000001642; RCN1.
DR VEuPathDB; FungiDB:YKL159C; -.
DR eggNOG; KOG4019; Eukaryota.
DR HOGENOM; CLU_1390040_0_0_1; -.
DR InParanoid; P36054; -.
DR OMA; MPPRSIF; -.
DR BioCyc; YEAST:G3O-31927-MON; -.
DR PRO; PR:P36054; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P36054; protein.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008597; F:calcium-dependent protein serine/threonine phosphatase regulator activity; IMP:SGD.
DR GO; GO:0030346; F:protein phosphatase 2B binding; IDA:SGD.
DR GO; GO:0019722; P:calcium-mediated signaling; IMP:SGD.
DR InterPro; IPR006931; Calcipressin.
DR InterPro; IPR016523; Rcn1_fungi.
DR PANTHER; PTHR10300; PTHR10300; 1.
DR Pfam; PF04847; Calcipressin; 1.
DR PIRSF; PIRSF007798; UCP007798; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..211
FT /note="Calcipressin-like protein"
FT /id="PRO_0000211424"
FT MOD_RES 113
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19779198"
FT MOD_RES 117
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18407956,
FT ECO:0007744|PubMed:19779198"
FT MOD_RES 182
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:19779198"
SQ SEQUENCE 211 AA; 24135 MW; 668EA0C10D4E39AA CRC64;
MGNIITDTII ITSDKCDIVD NDNVERIQVW LSKNILRKFQ INENEPLQLI ILKRFKRILL
ICPSHDISQH VMDASRALEM ENFNFSYSLQ DGQRNLTKQY LKVPESEKMF LISPPASPPP
EFDFSKCEDA PQRHIQSHIQ QDQQQRLEAS QLLPNNPDKN NNGTFTLLKS KVGAITIDRC
PTNDGNGQMQ LADHVKTAFP PKSIFDTDDD D
