RCNB_ECOLI
ID RCNB_ECOLI Reviewed; 112 AA.
AC P64534; P76426; Q2MAW9;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Nickel/cobalt homeostasis protein RcnB;
DE Flags: Precursor;
GN Name=rcnB; Synonyms=yohN; OrderedLocusNames=b2107, JW5346;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP PROTEIN SEQUENCE OF 26-31, FUNCTION, SUBCELLULAR LOCATION, INDUCTION, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=K12;
RX PubMed=21665978; DOI=10.1128/jb.05032-11;
RA Bleriot C., Effantin G., Lagarde F., Mandrand-Berthelot M.A., Rodrigue A.;
RT "RcnB is a periplasmic protein essential for maintaining intracellular Ni
RT and Co concentrations in Escherichia coli.";
RL J. Bacteriol. 193:3785-3793(2011).
CC -!- FUNCTION: Influences nickel and cobalt homeostasis. May act by
CC modulating RcnA-mediated export of these ions to avoid excess efflux.
CC Not involved in nickel import and does not bind nickel or cobalt ions
CC directly. {ECO:0000269|PubMed:21665978}.
CC -!- SUBCELLULAR LOCATION: Periplasm {ECO:0000269|PubMed:21665978}.
CC -!- INDUCTION: Repressed by RcnR. Induced by nickel and cobalt.
CC {ECO:0000269|PubMed:21665978}.
CC -!- DISRUPTION PHENOTYPE: Mutants show reduced intracellular nickel or
CC cobalt levels. {ECO:0000269|PubMed:21665978}.
CC -!- SIMILARITY: Belongs to the RcnB family. {ECO:0000305}.
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DR EMBL; U00096; AAC75168.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE76587.1; -; Genomic_DNA.
DR RefSeq; NP_416610.4; NC_000913.3.
DR RefSeq; WP_000153067.1; NZ_SSUV01000035.1.
DR AlphaFoldDB; P64534; -.
DR SMR; P64534; -.
DR BioGRID; 4260433; 2.
DR BioGRID; 853321; 4.
DR DIP; DIP-48070N; -.
DR IntAct; P64534; 6.
DR STRING; 511145.b2107; -.
DR TCDB; 2.A.113.1.1; the nickel/cobalt transporter (nico) family.
DR jPOST; P64534; -.
DR PaxDb; P64534; -.
DR PRIDE; P64534; -.
DR EnsemblBacteria; AAC75168; AAC75168; b2107.
DR EnsemblBacteria; BAE76587; BAE76587; BAE76587.
DR GeneID; 66673997; -.
DR GeneID; 949080; -.
DR KEGG; ecj:JW5346; -.
DR KEGG; eco:b2107; -.
DR PATRIC; fig|1411691.4.peg.140; -.
DR EchoBASE; EB3825; -.
DR eggNOG; COG5455; Bacteria.
DR HOGENOM; CLU_174019_0_0_6; -.
DR OMA; PEYTIKQ; -.
DR PhylomeDB; P64534; -.
DR BioCyc; EcoCyc:G7139-MON; -.
DR PRO; PR:P64534; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0005829; C:cytosol; IDA:EcoCyc.
DR GO; GO:0030288; C:outer membrane-bounded periplasmic space; IDA:EcoCyc.
DR GO; GO:0005507; F:copper ion binding; IDA:EcoCyc.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; IEP:EcoliWiki.
DR GO; GO:0032025; P:response to cobalt ion; IMP:EcoCyc.
DR GO; GO:0010045; P:response to nickel cation; IMP:EcoCyc.
DR GO; GO:1901652; P:response to peptide; IMP:EcoCyc.
DR InterPro; IPR024572; RcnB.
DR Pfam; PF11776; RcnB; 1.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Periplasm; Reference proteome; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000269|PubMed:21665978"
FT CHAIN 26..112
FT /note="Nickel/cobalt homeostasis protein RcnB"
FT /id="PRO_0000013872"
SQ SEQUENCE 112 AA; 12466 MW; C79685089608624F CRC64;
MTIKNKMLLG ALLLVTSAAW AAPATAGSTN TSGISKYELS SFIADFKHFK PGDTVPEMYR
TDEYNIKQWQ LRNLPAPDAG THWTYMGGAY VLISDTDGKI IKAYDGEIFY HR
