RCNR_ECOL5
ID RCNR_ECOL5 Reviewed; 90 AA.
AC Q0TFY7;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Transcriptional repressor RcnR;
GN Name=rcnR; OrderedLocusNames=ECP_2143;
OS Escherichia coli O6:K15:H31 (strain 536 / UPEC).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=362663;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=536 / UPEC;
RX PubMed=16879640; DOI=10.1111/j.1365-2958.2006.05255.x;
RA Hochhut B., Wilde C., Balling G., Middendorf B., Dobrindt U.,
RA Brzuszkiewicz E., Gottschalk G., Carniel E., Hacker J.;
RT "Role of pathogenicity island-associated integrases in the genome
RT plasticity of uropathogenic Escherichia coli strain 536.";
RL Mol. Microbiol. 61:584-595(2006).
CC -!- FUNCTION: Repressor of rcnA expression. Acts by binding specifically to
CC the rcnA promoter in the absence of nickel and cobalt. In the presence
CC of one of these metals, it has a weaker affinity for rcnA promoter (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the FrmR/RcnR family. {ECO:0000305}.
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DR EMBL; CP000247; ABG70142.1; -; Genomic_DNA.
DR RefSeq; WP_000019944.1; NC_008253.1.
DR AlphaFoldDB; Q0TFY7; -.
DR SMR; Q0TFY7; -.
DR STRING; 362663.ECP_2143; -.
DR EnsemblBacteria; ABG70142; ABG70142; ECP_2143.
DR GeneID; 67417885; -.
DR KEGG; ecp:ECP_2143; -.
DR HOGENOM; CLU_130332_3_0_6; -.
DR OMA; EHECAEI; -.
DR Proteomes; UP000009182; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:UniProt.
DR Gene3D; 1.20.58.1000; -; 1.
DR InterPro; IPR003735; Metal_Tscrpt_repr.
DR InterPro; IPR038390; Metal_Tscrpt_repr_sf.
DR PANTHER; PTHR33677; PTHR33677; 1.
DR Pfam; PF02583; Trns_repr_metal; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA-binding; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..90
FT /note="Transcriptional repressor RcnR"
FT /id="PRO_0000332696"
SQ SEQUENCE 90 AA; 10134 MW; BEF3E5AE971AA2F6 CRC64;
MSHTIRDKQK LKARASKIQG QVVALKKMLD EPHECAAVLQ QIAAIRGAVN GLMREVIKGH
LTEHIVHQGD ELKREEDLDV VLKVLDSYIK