ID   RCOR2_DANRE             Reviewed;         536 AA.
AC   Q6P116;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=REST corepressor 2;
GN   Name=rcor2; ORFNames=zgc:77264;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Pharyngula;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a component of a corepressor complex that
CC       represses transcription. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512,
CC       ECO:0000255|PROSITE-ProRule:PRU00624}.
CC   -!- SIMILARITY: Belongs to the CoREST family. {ECO:0000305}.
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DR   EMBL; BC065331; AAH65331.1; -; mRNA.
DR   RefSeq; NP_991201.1; NM_205638.1.
DR   RefSeq; XP_005172320.1; XM_005172263.3.
DR   AlphaFoldDB; Q6P116; -.
DR   SMR; Q6P116; -.
DR   STRING; 7955.ENSDARP00000026854; -.
DR   PaxDb; Q6P116; -.
DR   PRIDE; Q6P116; -.
DR   Ensembl; ENSDART00000002961; ENSDARP00000026854; ENSDARG00000008278.
DR   GeneID; 402934; -.
DR   KEGG; dre:402934; -.
DR   CTD; 283248; -.
DR   ZFIN; ZDB-GENE-040426-1812; rcor2.
DR   eggNOG; KOG1194; Eukaryota.
DR   GeneTree; ENSGT00940000154196; -.
DR   HOGENOM; CLU_026741_3_1_1; -.
DR   InParanoid; Q6P116; -.
DR   OMA; MDGISPP; -.
DR   OrthoDB; 641792at2759; -.
DR   PhylomeDB; Q6P116; -.
DR   TreeFam; TF106450; -.
DR   PRO; PR:Q6P116; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 7.
DR   Bgee; ENSDARG00000008278; Expressed in mature ovarian follicle and 30 other tissues.
DR   ExpressionAtlas; Q6P116; baseline and differential.
DR   GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR   GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR000949; ELM2_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   Pfam; PF01448; ELM2; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM01189; ELM2; 1.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51156; ELM2; 1.
DR   PROSITE; PS51293; SANT; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..536
FT                   /note="REST corepressor 2"
FT                   /id="PRO_0000226779"
FT   DOMAIN          38..123
FT                   /note="ELM2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00512"
FT   DOMAIN          124..175
FT                   /note="SANT 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   DOMAIN          328..379
FT                   /note="SANT 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          179..264
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          389..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          283..315
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..24
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        25..39
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        179..200
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        218..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        390..407
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        426..447
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        448..473
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        503..522
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   536 AA;  59791 MW;  B5E37AB3893D5196 CRC64;
     MERSGSGVLS RSRAKTVTNG NSQHSEEESS DEEHPNDSMI RVGGDYQAQI PEFKPDCASR
     YGEKDQRSML VWSPNSQVSD AMLDEYILMA KEKHGYNMEQ ALGMLLWHKH DVEKSLADLA
     NFTPFPDEWT VEDKVLFEQA FSFHGKSFHR IQQMLPDKMI TSLVKYYYSW KKTRTRTSVM
     DRQARKLLSK REKNESNDEI EEGDPGSDSD FEINAKKESA KQNSGNGGGN EKGPSKSCLT
     RKENQSAQYR HHPLRARRRP PKGMHLEQED IVALSASTDS GAVTIRQLDT QLVSLKRQVQ
     KIKQTNSVLR NNLGDGIEDM RPREPNQKIN SRWTTEEQLL AVQAVRRYGK DFAAIADVIG
     NKTVAQVSSF FVSYRRRFNL EEVLREWQAE QEVQGSSGRT VNTELNGSAE LEDDEVKMDG
     ISPPHSDSPL PSSEGSASGN HSSAQSSPPL TQPPPLLRPA PPSAPPSLLR QPPPLQTRPL
     QNRTPHNHPP PPLIRPAIAS TLHQGALRNS LSSSSSSAGQ LPPSLVGLKV ESPQSH