ID   RCOR2_XENLA             Reviewed;         503 AA.
AC   Q6NRZ0;
DT   07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=REST corepressor 2;
GN   Name=rcor2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a component of a corepressor complex that
CC       represses transcription. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512,
CC       ECO:0000255|PROSITE-ProRule:PRU00624}.
CC   -!- SIMILARITY: Belongs to the CoREST family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC070565; AAH70565.1; -; mRNA.
DR   RefSeq; NP_001084784.1; NM_001091315.1.
DR   RefSeq; XP_018112105.1; XM_018256616.1.
DR   AlphaFoldDB; Q6NRZ0; -.
DR   SMR; Q6NRZ0; -.
DR   BioGRID; 101187; 1.
DR   IntAct; Q6NRZ0; 1.
DR   MaxQB; Q6NRZ0; -.
DR   PRIDE; Q6NRZ0; -.
DR   DNASU; 431821; -.
DR   GeneID; 431821; -.
DR   KEGG; xla:431821; -.
DR   CTD; 431821; -.
DR   Xenbase; XB-GENE-6251773; rcor2.L.
DR   OMA; ASQYRHH; -.
DR   OrthoDB; 641792at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 431821; Expressed in egg cell and 18 other tissues.
DR   GO; GO:0005634; C:nucleus; IDA:BHF-UCL.
DR   GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:BHF-UCL.
DR   GO; GO:0003714; F:transcription corepressor activity; IDA:BHF-UCL.
DR   CDD; cd00167; SANT; 1.
DR   InterPro; IPR000949; ELM2_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   Pfam; PF01448; ELM2; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   SMART; SM01189; ELM2; 1.
DR   SMART; SM00717; SANT; 2.
DR   SUPFAM; SSF46689; SSF46689; 2.
DR   PROSITE; PS51156; ELM2; 1.
DR   PROSITE; PS51293; SANT; 2.
PE   2: Evidence at transcript level;
KW   Coiled coil; Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..503
FT                   /note="REST corepressor 2"
FT                   /id="PRO_0000226780"
FT   DOMAIN          41..126
FT                   /note="ELM2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00512"
FT   DOMAIN          127..178
FT                   /note="SANT 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   DOMAIN          327..378
FT                   /note="SANT 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          182..206
FT                   /evidence="ECO:0000255"
FT   COILED          286..314
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        1..22
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        395..433
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        446..488
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   503 AA;  56086 MW;  352B7FC9AD5E4061 CRC64;
     MPSVMEKSHG SSAVISRNRA KSDSLGNSEE ESSEDEAPRD SMIRVGSDYQ AQIPECKPDN
     TSPSGNVELK GMLVWSPSQF VSDAKLNEYI TMAKEKHGYN VEQSLGMLLW HKHDVERSLA
     DLANFTPFPE EWSVEDKVLF EQAFSFHGKS FQRIQQMLPE KLIPSLVKYY YSWKKTRSRT
     SVMDRQARRL QAKREEGMEE VEDQIKMSDN ETDVTETKKE APVPQKVVSG AVSGKTGPVR
     KEPLISQYRH HPLRSRQRPP KGIHLNKSDV SAVCASSEMP AIALCQLETQ LISLKRQVQN
     IKQMNSSLKE SLEGGISEMR PPELNIKLNA RWTTDEQLLA VQAVRKYGKD FQAISEVLGN
     KTPSQVKTFF ISYRRRFNLE EVLQEWEAEQ EPSPPPASTD MSNKTSGSSQ TPNEEDDEVQ
     ITSVSSSSQP APPAAAAAAS LSLPPPLLRP AIPCAPTLHR QPPPLQPGRL LQPRPPPLVR
     PAPRQSPRAP PALVGSHAES TFS