RCOR3_HUMAN
ID RCOR3_HUMAN Reviewed; 495 AA.
AC Q9P2K3; B3KYA2; B4DYY7; Q5VT47; Q7L9I5; Q8N5U3; Q9NV83;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 171.
DE RecName: Full=REST corepressor 3;
GN Name=RCOR3; Synonyms=KIAA1343;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10718198; DOI=10.1093/dnares/7.1.65;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVI. The
RT complete sequences of 150 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:65-73(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Pericardium, Teratocarcinoma, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ARG-42.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-156; SER-171 AND THR-376, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [8]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-445 AND ARG-457, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [9]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-20; LYS-193 AND LYS-285, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May act as a component of a corepressor complex that
CC represses transcription. {ECO:0000305}.
CC -!- INTERACTION:
CC Q9P2K3; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-743428, EBI-10171570;
CC Q9P2K3; Q01850: CDR2; NbExp=3; IntAct=EBI-743428, EBI-1181367;
CC Q9P2K3; Q53EZ4: CEP55; NbExp=3; IntAct=EBI-743428, EBI-747776;
CC Q9P2K3; Q08379: GOLGA2; NbExp=3; IntAct=EBI-743428, EBI-618309;
CC Q9P2K3; Q14687: GSE1; NbExp=9; IntAct=EBI-743428, EBI-372619;
CC Q9P2K3; Q9UKT9: IKZF3; NbExp=4; IntAct=EBI-743428, EBI-747204;
CC Q9P2K3; P19012: KRT15; NbExp=5; IntAct=EBI-743428, EBI-739566;
CC Q9P2K3; Q15323: KRT31; NbExp=3; IntAct=EBI-743428, EBI-948001;
CC Q9P2K3; Q6A162: KRT40; NbExp=3; IntAct=EBI-743428, EBI-10171697;
CC Q9P2K3; Q86VQ0: LCA5; NbExp=3; IntAct=EBI-743428, EBI-6658186;
CC Q9P2K3; Q9P127: LUZP4; NbExp=3; IntAct=EBI-743428, EBI-10198848;
CC Q9P2K3; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-743428, EBI-741037;
CC Q9P2K3; P43360: MAGEA6; NbExp=3; IntAct=EBI-743428, EBI-1045155;
CC Q9P2K3; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-743428, EBI-10172526;
CC Q9P2K3; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-743428, EBI-2548751;
CC Q9P2K3; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-743428, EBI-10172876;
CC Q9P2K3; Q9Y2I6: NINL; NbExp=4; IntAct=EBI-743428, EBI-719716;
CC Q9P2K3; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-743428, EBI-3957793;
CC Q9P2K3; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-743428, EBI-1105213;
CC Q9P2K3; Q12933: TRAF2; NbExp=4; IntAct=EBI-743428, EBI-355744;
CC Q9P2K3; P14373: TRIM27; NbExp=3; IntAct=EBI-743428, EBI-719493;
CC Q9P2K3; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-743428, EBI-5235829;
CC Q9P2K3; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-743428, EBI-2130429;
CC Q9P2K3; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-743428, EBI-744794;
CC Q9P2K3; P40222: TXLNA; NbExp=3; IntAct=EBI-743428, EBI-359793;
CC Q9P2K3-2; Q8IZP0-5: ABI1; NbExp=3; IntAct=EBI-1504830, EBI-11743294;
CC Q9P2K3-2; X5D778: ANKRD11; NbExp=3; IntAct=EBI-1504830, EBI-17183751;
CC Q9P2K3-2; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-1504830, EBI-11519926;
CC Q9P2K3-2; Q96GS4: BORCS6; NbExp=3; IntAct=EBI-1504830, EBI-10193358;
CC Q9P2K3-2; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-1504830, EBI-11524851;
CC Q9P2K3-2; Q9BWC9: CCDC106; NbExp=3; IntAct=EBI-1504830, EBI-711501;
CC Q9P2K3-2; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-1504830, EBI-10175300;
CC Q9P2K3-2; Q96MT8-3: CEP63; NbExp=3; IntAct=EBI-1504830, EBI-11522539;
CC Q9P2K3-2; Q5JST6: EFHC2; NbExp=3; IntAct=EBI-1504830, EBI-2349927;
CC Q9P2K3-2; Q8TBF8: FAM81A; NbExp=3; IntAct=EBI-1504830, EBI-11993062;
CC Q9P2K3-2; P22607: FGFR3; NbExp=3; IntAct=EBI-1504830, EBI-348399;
CC Q9P2K3-2; A1L4K1: FSD2; NbExp=3; IntAct=EBI-1504830, EBI-5661036;
CC Q9P2K3-2; Q5VSY0: GKAP1; NbExp=3; IntAct=EBI-1504830, EBI-743722;
CC Q9P2K3-2; O76003: GLRX3; NbExp=3; IntAct=EBI-1504830, EBI-374781;
CC Q9P2K3-2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-1504830, EBI-618309;
CC Q9P2K3-2; Q4V328: GRIPAP1; NbExp=3; IntAct=EBI-1504830, EBI-717919;
CC Q9P2K3-2; Q14687: GSE1; NbExp=3; IntAct=EBI-1504830, EBI-372619;
CC Q9P2K3-2; P06396: GSN; NbExp=3; IntAct=EBI-1504830, EBI-351506;
CC Q9P2K3-2; Q68CZ6: HAUS3; NbExp=3; IntAct=EBI-1504830, EBI-2558217;
CC Q9P2K3-2; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-1504830, EBI-2549423;
CC Q9P2K3-2; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-1504830, EBI-10961706;
CC Q9P2K3-2; P01112: HRAS; NbExp=3; IntAct=EBI-1504830, EBI-350145;
CC Q9P2K3-2; O75031: HSF2BP; NbExp=3; IntAct=EBI-1504830, EBI-7116203;
CC Q9P2K3-2; Q8NDH6-2: ICA1L; NbExp=3; IntAct=EBI-1504830, EBI-12141931;
CC Q9P2K3-2; Q8WYH8: ING5; NbExp=3; IntAct=EBI-1504830, EBI-488533;
CC Q9P2K3-2; Q9ULR0-1: ISY1; NbExp=3; IntAct=EBI-1504830, EBI-18398632;
CC Q9P2K3-2; O60341: KDM1A; NbExp=6; IntAct=EBI-1504830, EBI-710124;
CC Q9P2K3-2; O60333-2: KIF1B; NbExp=3; IntAct=EBI-1504830, EBI-10975473;
CC Q9P2K3-2; P19012: KRT15; NbExp=3; IntAct=EBI-1504830, EBI-739566;
CC Q9P2K3-2; P05783: KRT18; NbExp=3; IntAct=EBI-1504830, EBI-297888;
CC Q9P2K3-2; P08727: KRT19; NbExp=3; IntAct=EBI-1504830, EBI-742756;
CC Q9P2K3-2; Q2M2I5: KRT24; NbExp=3; IntAct=EBI-1504830, EBI-2952736;
CC Q9P2K3-2; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-1504830, EBI-3044087;
CC Q9P2K3-2; Q15323: KRT31; NbExp=3; IntAct=EBI-1504830, EBI-948001;
CC Q9P2K3-2; O95678: KRT75; NbExp=3; IntAct=EBI-1504830, EBI-2949715;
CC Q9P2K3-2; Q86VQ0: LCA5; NbExp=3; IntAct=EBI-1504830, EBI-6658186;
CC Q9P2K3-2; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-1504830, EBI-12039345;
CC Q9P2K3-2; P43360: MAGEA6; NbExp=3; IntAct=EBI-1504830, EBI-1045155;
CC Q9P2K3-2; P23508: MCC; NbExp=3; IntAct=EBI-1504830, EBI-307531;
CC Q9P2K3-2; Q14696: MESD; NbExp=3; IntAct=EBI-1504830, EBI-6165891;
CC Q9P2K3-2; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-1504830, EBI-10172526;
CC Q9P2K3-2; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-1504830, EBI-11522433;
CC Q9P2K3-2; P17568: NDUFB7; NbExp=3; IntAct=EBI-1504830, EBI-1246238;
CC Q9P2K3-2; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-1504830, EBI-10172876;
CC Q9P2K3-2; P07196: NEFL; NbExp=3; IntAct=EBI-1504830, EBI-475646;
CC Q9P2K3-2; Q9H7Z3: NRDE2; NbExp=3; IntAct=EBI-1504830, EBI-1042642;
CC Q9P2K3-2; Q5T6S3: PHF19; NbExp=3; IntAct=EBI-1504830, EBI-2339674;
CC Q9P2K3-2; A0A0S2Z615: PHF21B; NbExp=3; IntAct=EBI-1504830, EBI-16434035;
CC Q9P2K3-2; Q96EK2-3: PHF21B; NbExp=3; IntAct=EBI-1504830, EBI-16437793;
CC Q9P2K3-2; Q9NWS0: PIH1D1; NbExp=3; IntAct=EBI-1504830, EBI-357318;
CC Q9P2K3-2; P60891: PRPS1; NbExp=3; IntAct=EBI-1504830, EBI-749195;
CC Q9P2K3-2; Q9NZH5-2: PTTG2; NbExp=3; IntAct=EBI-1504830, EBI-17630019;
CC Q9P2K3-2; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-1504830, EBI-5235340;
CC Q9P2K3-2; Q9H668: STN1; NbExp=3; IntAct=EBI-1504830, EBI-746930;
CC Q9P2K3-2; Q13077: TRAF1; NbExp=3; IntAct=EBI-1504830, EBI-359224;
CC Q9P2K3-2; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-1504830, EBI-2130429;
CC Q9P2K3-2; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-1504830, EBI-739895;
CC Q9P2K3-2; Q5SQQ9-2: VAX1; NbExp=3; IntAct=EBI-1504830, EBI-12227803;
CC Q9P2K3-2; O76024: WFS1; NbExp=3; IntAct=EBI-1504830, EBI-720609;
CC Q9P2K3-2; Q8NA42: ZNF383; NbExp=3; IntAct=EBI-1504830, EBI-20110775;
CC Q9P2K3-2; P0C7X2: ZNF688; NbExp=3; IntAct=EBI-1504830, EBI-4395732;
CC Q9P2K3-2; Q9Y649; NbExp=3; IntAct=EBI-1504830, EBI-25900580;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512,
CC ECO:0000255|PROSITE-ProRule:PRU00624}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9P2K3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9P2K3-2; Sequence=VSP_017460, VSP_017461, VSP_017462;
CC Name=3;
CC IsoId=Q9P2K3-3; Sequence=VSP_017460;
CC Name=4;
CC IsoId=Q9P2K3-4; Sequence=VSP_017460, VSP_041465, VSP_041466;
CC -!- SIMILARITY: Belongs to the CoREST family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB037764; BAA92581.1; ALT_INIT; mRNA.
DR EMBL; AK131312; BAG54764.1; -; mRNA.
DR EMBL; AK302664; BAG63899.1; -; mRNA.
DR EMBL; AK001738; BAA91872.1; -; mRNA.
DR EMBL; AL590101; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL611964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031608; AAH31608.1; -; mRNA.
DR CCDS; CCDS31016.1; -. [Q9P2K3-1]
DR CCDS; CCDS44312.1; -. [Q9P2K3-3]
DR CCDS; CCDS44313.1; -. [Q9P2K3-2]
DR CCDS; CCDS44314.1; -. [Q9P2K3-4]
DR RefSeq; NP_001129695.1; NM_001136223.1. [Q9P2K3-3]
DR RefSeq; NP_001129696.2; NM_001136224.2. [Q9P2K3-2]
DR RefSeq; NP_001129697.1; NM_001136225.1. [Q9P2K3-4]
DR RefSeq; NP_060724.1; NM_018254.3. [Q9P2K3-1]
DR PDB; 4CZZ; X-ray; 3.00 A; B=1-495.
DR PDBsum; 4CZZ; -.
DR AlphaFoldDB; Q9P2K3; -.
DR SMR; Q9P2K3; -.
DR BioGRID; 120876; 168.
DR CORUM; Q9P2K3; -.
DR IntAct; Q9P2K3; 133.
DR MINT; Q9P2K3; -.
DR STRING; 9606.ENSP00000413929; -.
DR BindingDB; Q9P2K3; -.
DR ChEMBL; CHEMBL4296112; -.
DR ChEMBL; CHEMBL4296114; -.
DR iPTMnet; Q9P2K3; -.
DR PhosphoSitePlus; Q9P2K3; -.
DR BioMuta; RCOR3; -.
DR DMDM; 90103520; -.
DR EPD; Q9P2K3; -.
DR jPOST; Q9P2K3; -.
DR MassIVE; Q9P2K3; -.
DR MaxQB; Q9P2K3; -.
DR PaxDb; Q9P2K3; -.
DR PeptideAtlas; Q9P2K3; -.
DR PRIDE; Q9P2K3; -.
DR ProteomicsDB; 83829; -. [Q9P2K3-1]
DR ProteomicsDB; 83830; -. [Q9P2K3-2]
DR ProteomicsDB; 83831; -. [Q9P2K3-3]
DR ProteomicsDB; 83832; -. [Q9P2K3-4]
DR Antibodypedia; 2380; 113 antibodies from 20 providers.
DR DNASU; 55758; -.
DR Ensembl; ENST00000367005.8; ENSP00000355972.4; ENSG00000117625.14. [Q9P2K3-1]
DR Ensembl; ENST00000367006.8; ENSP00000355973.4; ENSG00000117625.14. [Q9P2K3-2]
DR Ensembl; ENST00000419091.7; ENSP00000413929.2; ENSG00000117625.14. [Q9P2K3-3]
DR Ensembl; ENST00000452621.6; ENSP00000398558.2; ENSG00000117625.14. [Q9P2K3-4]
DR GeneID; 55758; -.
DR KEGG; hsa:55758; -.
DR MANE-Select; ENST00000419091.7; ENSP00000413929.2; NM_001136223.3; NP_001129695.1. [Q9P2K3-3]
DR UCSC; uc001hie.4; human. [Q9P2K3-1]
DR CTD; 55758; -.
DR DisGeNET; 55758; -.
DR GeneCards; RCOR3; -.
DR HGNC; HGNC:25594; RCOR3.
DR HPA; ENSG00000117625; Low tissue specificity.
DR neXtProt; NX_Q9P2K3; -.
DR OpenTargets; ENSG00000117625; -.
DR PharmGKB; PA134917623; -.
DR VEuPathDB; HostDB:ENSG00000117625; -.
DR eggNOG; KOG1194; Eukaryota.
DR GeneTree; ENSGT00940000154196; -.
DR HOGENOM; CLU_026741_1_0_1; -.
DR InParanoid; Q9P2K3; -.
DR OMA; XSNQKIN; -.
DR OrthoDB; 641792at2759; -.
DR PhylomeDB; Q9P2K3; -.
DR TreeFam; TF106450; -.
DR PathwayCommons; Q9P2K3; -.
DR SignaLink; Q9P2K3; -.
DR BioGRID-ORCS; 55758; 12 hits in 1101 CRISPR screens.
DR ChiTaRS; RCOR3; human.
DR GenomeRNAi; 55758; -.
DR Pharos; Q9P2K3; Tdark.
DR PRO; PR:Q9P2K3; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9P2K3; protein.
DR Bgee; ENSG00000117625; Expressed in sperm and 199 other tissues.
DR ExpressionAtlas; Q9P2K3; baseline and differential.
DR Genevisible; Q9P2K3; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00167; SANT; 1.
DR DisProt; DP02408; -. [Q9P2K3-3]
DR IDEAL; IID00589; -.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR Pfam; PF01448; ELM2; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; SSF46689; 2.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 2.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Coiled coil; Isopeptide bond;
KW Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW Repressor; Transcription; Transcription regulation; Ubl conjugation.
FT CHAIN 1..495
FT /note="REST corepressor 3"
FT /id="PRO_0000226781"
FT DOMAIN 1..83
FT /note="ELM2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00512"
FT DOMAIN 84..135
FT /note="SANT 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT DOMAIN 285..336
FT /note="SANT 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT REGION 147..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 237..273
FT /evidence="ECO:0000255"
FT COMPBIAS 166..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..373
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..430
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..465
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..495
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 156
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 171
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 376
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 445
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 457
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT CROSSLNK 20
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 193
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 285
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1
FT /note="M -> MPGMMEKGPELLGKNRSANGSAKSPAGGGGSGASSTNGGLHYSEPES
FT GCSSDDEHDVGM (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_017460"
FT VAR_SEQ 302..378
FT /note="VRKYGKDFQAIADVIGNKTVGQVKNFFVNYRRRFNLEEVLQEWEAEQGTQAS
FT NGDASTLGEETKSASNVPSGKSTDE -> TDPTGSSDTGSITSCPIIHSNTNSPYCHSE
FT PASTTSSSNTACCPGSSPAASSTPAAGSVHPAPANFKSASTTSYSPC (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017461"
FT VAR_SEQ 379..495
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017462"
FT VAR_SEQ 382..391
FT /note="AQTPQAPRTL -> VCLCMEFELI (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041465"
FT VAR_SEQ 392..495
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_041466"
FT VARIANT 42
FT /note="K -> R (in dbSNP:rs17856928)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_025517"
FT HELIX 225..232
FT /evidence="ECO:0007829|PDB:4CZZ"
FT STRAND 233..236
FT /evidence="ECO:0007829|PDB:4CZZ"
FT HELIX 237..269
FT /evidence="ECO:0007829|PDB:4CZZ"
FT TURN 270..272
FT /evidence="ECO:0007829|PDB:4CZZ"
FT HELIX 275..277
FT /evidence="ECO:0007829|PDB:4CZZ"
FT HELIX 292..305
FT /evidence="ECO:0007829|PDB:4CZZ"
FT HELIX 309..316
FT /evidence="ECO:0007829|PDB:4CZZ"
FT HELIX 322..331
FT /evidence="ECO:0007829|PDB:4CZZ"
FT TURN 332..336
FT /evidence="ECO:0007829|PDB:4CZZ"
FT HELIX 337..345
FT /evidence="ECO:0007829|PDB:4CZZ"
SQ SEQUENCE 495 AA; 55581 MW; 2673C9DDD3C176E4 CRC64;
MRVGAEYQAR IPEFDPGATK YTDKDNGGML VWSPYHSIPD AKLDEYIAIA KEKHGYNVEQ
ALGMLFWHKH NIEKSLADLP NFTPFPDEWT VEDKVLFEQA FSFHGKSFHR IQQMLPDKTI
ASLVKYYYSW KKTRSRTSLM DRQARKLANR HNQGDSDDDV EETHPMDGND SDYDPKKEAK
KEGNTEQPVQ TSKIGLGRRE YQSLQHRHHS QRSKCRPPKG MYLTQEDVVA VSCSPNAANT
ILRQLDMELI SLKRQVQNAK QVNSALKQKM EGGIEEFKPP ESNQKINARW TTEEQLLAVQ
GVRKYGKDFQ AIADVIGNKT VGQVKNFFVN YRRRFNLEEV LQEWEAEQGT QASNGDASTL
GEETKSASNV PSGKSTDEEE EAQTPQAPRT LGPSPPAPSS TPTPTAPIAT LNQPPPLLRP
TLPAAPALHR QPPPLQQQAR FIQPRPTLNQ PPPPLIRPAN SMPPRLNPRP VLSTVGGQQP
PSLIGIQTDS QSSLH
