RCOR3_MOUSE
ID RCOR3_MOUSE Reviewed; 451 AA.
AC Q6PGA0;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=REST corepressor 3;
GN Name=Rcor3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Adrenal gland;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 38-451 (ISOFORM 1).
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-212 AND SER-227, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Heart, Kidney, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-401 AND ARG-413, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, and Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: May act as a component of a corepressor complex that
CC represses transcription. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00512,
CC ECO:0000255|PROSITE-ProRule:PRU00624}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PGA0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PGA0-2; Sequence=VSP_017463, VSP_017464;
CC -!- SIMILARITY: Belongs to the CoREST family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57141.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AK135612; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK135612; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BC057141; AAH57141.2; ALT_INIT; mRNA.
DR CCDS; CCDS69995.1; -. [Q6PGA0-1]
DR CCDS; CCDS69996.1; -. [Q6PGA0-2]
DR RefSeq; NP_001277207.1; NM_001290278.1. [Q6PGA0-2]
DR RefSeq; NP_659063.3; NM_144814.3. [Q6PGA0-1]
DR AlphaFoldDB; Q6PGA0; -.
DR SMR; Q6PGA0; -.
DR BioGRID; 229560; 2.
DR IntAct; Q6PGA0; 1.
DR STRING; 10090.ENSMUSP00000073004; -.
DR iPTMnet; Q6PGA0; -.
DR PhosphoSitePlus; Q6PGA0; -.
DR EPD; Q6PGA0; -.
DR MaxQB; Q6PGA0; -.
DR PaxDb; Q6PGA0; -.
DR PRIDE; Q6PGA0; -.
DR ProteomicsDB; 300327; -. [Q6PGA0-1]
DR ProteomicsDB; 300328; -. [Q6PGA0-2]
DR Antibodypedia; 2380; 113 antibodies from 20 providers.
DR DNASU; 214742; -.
DR Ensembl; ENSMUST00000073279; ENSMUSP00000073004; ENSMUSG00000037395. [Q6PGA0-1]
DR Ensembl; ENSMUST00000110849; ENSMUSP00000106473; ENSMUSG00000037395. [Q6PGA0-2]
DR GeneID; 214742; -.
DR KEGG; mmu:214742; -.
DR UCSC; uc007edh.2; mouse. [Q6PGA0-1]
DR UCSC; uc007edi.2; mouse. [Q6PGA0-2]
DR CTD; 55758; -.
DR MGI; MGI:2441920; Rcor3.
DR VEuPathDB; HostDB:ENSMUSG00000037395; -.
DR eggNOG; KOG1194; Eukaryota.
DR GeneTree; ENSGT00940000154196; -.
DR InParanoid; Q6PGA0; -.
DR PhylomeDB; Q6PGA0; -.
DR TreeFam; TF106450; -.
DR BioGRID-ORCS; 214742; 3 hits in 55 CRISPR screens.
DR ChiTaRS; Rcor3; mouse.
DR PRO; PR:Q6PGA0; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q6PGA0; protein.
DR Bgee; ENSMUSG00000037395; Expressed in spermatocyte and 69 other tissues.
DR ExpressionAtlas; Q6PGA0; baseline and differential.
DR Genevisible; Q6PGA0; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0019899; F:enzyme binding; IPI:MGI.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0016575; P:histone deacetylation; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR000949; ELM2_dom.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR Pfam; PF01448; ELM2; 1.
DR SMART; SM01189; ELM2; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS51156; ELM2; 1.
DR PROSITE; PS51293; SANT; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Isopeptide bond; Methylation; Nucleus;
KW Phosphoprotein; Reference proteome; Repressor; Transcription;
KW Transcription regulation; Ubl conjugation.
FT CHAIN 1..451
FT /note="REST corepressor 3"
FT /id="PRO_0000226782"
FT DOMAIN 55..139
FT /note="ELM2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00512"
FT DOMAIN 140..191
FT /note="SANT"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT REGION 1..55
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 293..329
FT /evidence="ECO:0000255"
FT COMPBIAS 222..240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 345..386
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 402..421
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 227
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 401
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 413
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT CROSSLNK 76
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9P2K3"
FT CROSSLNK 249
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9P2K3"
FT VAR_SEQ 338..434
FT /note="AQTPQAPRTLGPSPPAPSSTPTPTVPIATLNQPPPLLRPTLPAAPALHRQPP
FT PLQQQARFIQPRPTLNQPPPPLIRPANSMPPRLNPRPVLTTVGGQ -> SNQKINARWT
FT TEEQLLAVQGTDPTGSSDSGSITSCPIIHSNTNSPHCHSEPASTTSSSNTACRPCSSPT
FT TSSTPAAGSVHPAPANSQSASSTSHSPC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_017463"
FT VAR_SEQ 435..451
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_017464"
SQ SEQUENCE 451 AA; 49779 MW; FE0A068325A06C82 CRC64;
MPGMMEKGPE LLGKSRSANG GAKSPAGGGG SSANGGLHFS EPESGCSSDD EHGDVGMRVG
AEYQARIPEF DPGATKYTDK DNGGMLVWSP YHSIPDAKLD EYIAIAKEKH GYNVEQALGM
LFWHKHNIEK SLADLPNFTP FPDEWTVEDK VLFEQAFSFH GKSFHRIQQM LPDKTIASLV
KYYYSWKKTR SRTSLMDRQA RKLANRHNQG DSDDDVEEAH PMDGNDSDYD PKKEAKREGN
ADQPVQTSKI GLGRREYQSL QHRHHSQRSK CRPPKGMYLT QEDVVAVSCS PNAANTILRQ
LDMELISLKR QVQNAKQVNS ALKQKMEGGI EEFKPPEAQT PQAPRTLGPS PPAPSSTPTP
TVPIATLNQP PPLLRPTLPA APALHRQPPP LQQQARFIQP RPTLNQPPPP LIRPANSMPP
RLNPRPVLTT VGGQQPPSLI GIQTDSQPSL H
