ID   RCRO_BPD3               Reviewed;          73 AA.
AC   Q37907;
DT   15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT   27-MAY-2002, sequence version 2.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Regulatory protein cro;
DE   AltName: Full=Antirepressor;
GN   Name=cro;
OS   Pseudomonas phage D3 (Bacteriophage D3).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Siphoviridae; Detrevirus.
OX   NCBI_TaxID=31535;
OH   NCBI_TaxID=287; Pseudomonas aeruginosa.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8050993; DOI=10.1128/jb.176.16.4809-4815.1994;
RA   Farinha M.A., Allan B.J., Gertman E.M., Ronald S.L., Kropinski A.M.;
RT   "Cloning of the early promoters of Pseudomonas aeruginosa bacteriophage D3:
RT   sequence of the immunity region of D3.";
RL   J. Bacteriol. 176:4809-4815(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO C-TERMINUS.
RX   PubMed=11029426; DOI=10.1128/jb.182.21.6066-6074.2000;
RA   Kropinski A.M.;
RT   "Sequence of the genome of the temperate, serotype-converting, Pseudomonas
RT   aeruginosa bacteriophage D3.";
RL   J. Bacteriol. 182:6066-6074(2000).
CC   -!- FUNCTION: Cro represses genes normally expressed in early phage
CC       development and is necessary for the late stage of lytic growth. It
CC       does this by binding to the OL and OR operators regions normally used
CC       by the repressor protein for lysogenic maintenance (By similarity).
CC       {ECO:0000250}.
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DR   EMBL; AF165214; AAA53554.2; -; Genomic_DNA.
DR   PIR; B55847; B55847.
DR   RefSeq; NP_061566.1; NC_002484.2.
DR   SMR; Q37907; -.
DR   GeneID; 1262917; -.
DR   KEGG; vg:1262917; -.
DR   Proteomes; UP000009085; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   CDD; cd00093; HTH_XRE; 1.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   InterPro; IPR031856; YdaS_toxin.
DR   Pfam; PF15943; YdaS_antitoxin; 1.
DR   SUPFAM; SSF47413; SSF47413; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Early protein; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..73
FT                   /note="Regulatory protein cro"
FT                   /id="PRO_0000077576"
FT   DNA_BIND        15..34
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   73 AA;  7934 MW;  287D09D8C97C8035 CRC64;
     MTTIYKELVA HFGTQDETAA KLGVDQSTVS GWVRGKHGMS PVVAKRAQVL TDGKFKKEDL
     CPAFPWEVLS AVA