ID   RCRO_BPP22              Reviewed;          61 AA.
AC   P09964; Q38659; Q7PCF1;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   02-JUN-2021, entry version 103.
DE   RecName: Full=Regulatory protein cro;
DE   AltName: Full=Antirepressor;
GN   Name=cro;
OS   Salmonella phage P22 (Bacteriophage P22).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Podoviridae; Lederbergvirus.
OX   NCBI_TaxID=10754;
OH   NCBI_TaxID=90371; Salmonella typhimurium.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3954988; DOI=10.1021/bi00349a035;
RA   Poteete A.R., Hehir K., Sauer R.T.;
RT   "Bacteriophage P22 Cro protein: sequence, purification, and properties.";
RL   Biochemistry 25:251-256(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11053393; DOI=10.1128/jb.182.22.6472-6481.2000;
RA   Vander Byl C.S., Kropinski A.M.B.;
RT   "Sequence of the genome of Salmonella bacteriophage P22.";
RL   J. Bacteriol. 182:6472-6481(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12562822; DOI=10.1128/jb.185.4.1475-1477.2003;
RA   Pedulla M.L., Ford M.E., Karthikeyan T., Houtz J.M., Hendrix R.W.,
RA   Hatfull G.F., Poteete A.R., Gilcrease E.B., Winn-Stapley D.A.,
RA   Casjens S.R.;
RT   "Corrected sequence of the bacteriophage P22 genome.";
RL   J. Bacteriol. 185:1475-1477(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 47-61.
RX   PubMed=6241581; DOI=10.1016/0378-1119(84)90004-0;
RA   Backhaus H., Petri J.B.;
RT   "Sequence analysis of a region from the early right operon in phage P22
RT   including the replication genes 18 and 12.";
RL   Gene 32:289-303(1984).
RN   [5]
RP   STRUCTURE BY NMR.
RX   PubMed=15062080; DOI=10.1016/j.str.2004.02.024;
RA   Newlove T., Konieczka J.H., Cordes M.H.;
RT   "Secondary structure switching in Cro protein evolution.";
RL   Structure 12:569-581(2004).
CC   -!- FUNCTION: Cro represses genes normally expressed in early phage
CC       development and is necessary for the late stage of lytic growth. It
CC       does this by binding to the OL and OR operators regions normally used
CC       by the repressor protein for lysogenic maintenance.
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DR   EMBL; M12584; AAA32268.1; -; Genomic_DNA.
DR   EMBL; AF217253; AAF75025.1; -; Genomic_DNA.
DR   EMBL; BK000583; DAA01022.1; -; Genomic_DNA.
DR   EMBL; M10074; AAA32273.1; -; Genomic_DNA.
DR   PIR; A25867; RGBP22.
DR   RefSeq; NP_059607.1; NC_002371.2.
DR   PDB; 1RZS; NMR; -; A=1-61.
DR   PDBsum; 1RZS; -.
DR   BMRB; P09964; -.
DR   SMR; P09964; -.
DR   GeneID; 1262827; -.
DR   KEGG; vg:1262827; -.
DR   EvolutionaryTrace; P09964; -.
DR   Proteomes; UP000001795; Genome.
DR   Proteomes; UP000007960; Genome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
DR   SUPFAM; SSF47413; SSF47413; 1.
PE   1: Evidence at protein level;
KW   3D-structure; DNA-binding; Early protein; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..61
FT                   /note="Regulatory protein cro"
FT                   /id="PRO_0000077578"
FT   DNA_BIND        13..32
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
FT   HELIX           3..10
FT                   /evidence="ECO:0007829|PDB:1RZS"
FT   HELIX           13..20
FT                   /evidence="ECO:0007829|PDB:1RZS"
FT   HELIX           24..29
FT                   /evidence="ECO:0007829|PDB:1RZS"
FT   HELIX           36..45
FT                   /evidence="ECO:0007829|PDB:1RZS"
SQ   SEQUENCE   61 AA;  6828 MW;  CD37A130D8CF14AF CRC64;
     MYKKDVIDHF GTQRAVAKAL GISDAAVSQW KEVIPEKDAY RLEIVTAGAL KYQENAYRQA
     A