ID   RCSA_KLEAE              Reviewed;         207 AA.
AC   P05338;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Transcriptional regulatory protein RcsA {ECO:0000255|HAMAP-Rule:MF_00982};
GN   Name=rcsA {ECO:0000255|HAMAP-Rule:MF_00982};
OS   Klebsiella aerogenes (Enterobacter aerogenes).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX   NCBI_TaxID=548;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3309150; DOI=10.1099/00221287-133-2-331;
RA   Allen P., Hart C.A., Saunders J.R.;
RT   "Isolation from Klebsiella and characterization of two rcs genes that
RT   activate colanic acid capsular biosynthesis in Escherichia coli.";
RL   J. Gen. Microbiol. 133:331-340(1987).
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. Binds to DNA to regulate expression of
CC       genes. {ECO:0000255|HAMAP-Rule:MF_00982}.
CC   -!- SIMILARITY: Belongs to the RcsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00982}.
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DR   EMBL; M15748; AAA25142.1; -; Genomic_DNA.
DR   RefSeq; WP_002911561.1; NZ_LR134254.1.
DR   AlphaFoldDB; P05338; -.
DR   SMR; P05338; -.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00982; RcsA; 1.
DR   InterPro; IPR030866; RcsA.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sensory transduction; Transcription; Transcription regulation.
FT   CHAIN           1..207
FT                   /note="Transcriptional regulatory protein RcsA"
FT                   /id="PRO_0000184184"
FT   DOMAIN          131..196
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00982"
FT   DNA_BIND        155..174
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00982"
SQ   SEQUENCE   207 AA;  23366 MW;  24E2253BB9DEE162 CRC64;
     MSTMIMDLCS YTRLGLTGYL TSRGIKKQEI VEVNSAADLQ KHCTSCCPAV VFLNEDCFVH
     DDESNGIIRQ IITQNPATLF VIFMSLANIH FDRYLRVRKN LLISSKSITP KDLDVILVNY
     LKYKNTSVGQ LTLPTLSLSK TESNMLQMWM AGHGTSQIST QMNIKAKTVS SHKGNIKKKI
     QTHNKQVIYH IVRLTENITS GIQVNMR