ID   RCSA_SALTI              Reviewed;         207 AA.
AC   Q56083;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=Transcriptional regulatory protein RcsA {ECO:0000255|HAMAP-Rule:MF_00982};
GN   Name=rcsA {ECO:0000255|HAMAP-Rule:MF_00982};
GN   OrderedLocusNames=STY2190, t0895;
OS   Salmonella typhi.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=90370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=8626298; DOI=10.1128/jb.178.6.1691-1698.1996;
RA   Virlogeux I., Waxin H., Ecobichon C., Lee J.O., Popoff M.Y.;
RT   "Characterization of the rcsA and rcsB genes from Salmonella typhi: rcsB
RT   through tviA is involved in regulation of Vi antigen synthesis.";
RL   J. Bacteriol. 178:1691-1698(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CT18;
RX   PubMed=11677608; DOI=10.1038/35101607;
RA   Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA   Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA   Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA   Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA   Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA   Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA   Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA   Barrell B.G.;
RT   "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT   serovar Typhi CT18.";
RL   Nature 413:848-852(2001).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700931 / Ty2;
RX   PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA   Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA   Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT   "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT   CT18.";
RL   J. Bacteriol. 185:2330-2337(2003).
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. Binds, with RcsB, to the RcsAB box to
CC       regulate expression of genes. {ECO:0000255|HAMAP-Rule:MF_00982}.
CC   -!- SUBUNIT: Interacts with RcsB. {ECO:0000255|HAMAP-Rule:MF_00982}.
CC   -!- SIMILARITY: Belongs to the RcsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00982}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; X87687; CAA61019.1; -; Genomic_DNA.
DR   EMBL; AL513382; CAD05730.1; -; Genomic_DNA.
DR   EMBL; AE014613; AAO68573.1; -; Genomic_DNA.
DR   RefSeq; NP_456543.1; NC_003198.1.
DR   RefSeq; WP_000103972.1; NZ_WSUR01000004.1.
DR   AlphaFoldDB; Q56083; -.
DR   SMR; Q56083; -.
DR   STRING; 220341.16503223; -.
DR   EnsemblBacteria; AAO68573; AAO68573; t0895.
DR   KEGG; stt:t0895; -.
DR   KEGG; sty:STY2190; -.
DR   PATRIC; fig|220341.7.peg.2205; -.
DR   eggNOG; COG2771; Bacteria.
DR   HOGENOM; CLU_105065_0_0_6; -.
DR   OMA; ANIHFDE; -.
DR   Proteomes; UP000000541; Chromosome.
DR   Proteomes; UP000002670; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00982; RcsA; 1.
DR   InterPro; IPR030866; RcsA.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Sensory transduction; Transcription; Transcription regulation.
FT   CHAIN           1..207
FT                   /note="Transcriptional regulatory protein RcsA"
FT                   /id="PRO_0000184180"
FT   DOMAIN          131..196
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00982"
FT   DNA_BIND        155..174
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00982"
SQ   SEQUENCE   207 AA;  23274 MW;  4DC34F9501C66999 CRC64;
     MSTIIMDLCS YTRLGLSGYL VSRGVKKREI NDIETVDELA IACGAHQPSV VFINEDCFIH
     TPSDSQQIKQ IINQHPDTLF IVFMAIANVH FDEYLLVRKN LLISSKSIKP DSLDTLLGDI
     LKKESGISGT INLPTLSLSR TESSMLRMWM EGQGTIQISD RMNIKAKTVS SHKGNIKRKI
     KTHNKQVIYH VVRLTDNVTN GIFANMR