ID   RCSA_SALTY              Reviewed;         207 AA.
AC   P54698;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   13-DEC-2001, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Transcriptional regulatory protein RcsA {ECO:0000255|HAMAP-Rule:MF_00982};
GN   Name=rcsA {ECO:0000255|HAMAP-Rule:MF_00982}; OrderedLocusNames=STM1982;
OS   Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Salmonella.
OX   NCBI_TaxID=99287;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX   PubMed=11677609; DOI=10.1038/35101614;
RA   McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA   Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA   Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA   Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA   Wilson R.K.;
RT   "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL   Nature 413:852-856(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-65.
RC   STRAIN=LT2;
RX   PubMed=9324257; DOI=10.1128/jb.179.19.6092-6099.1997;
RA   Ohnishi K., Fan F., Schoenhals G.J., Kihara M., Macnab R.M.;
RT   "The FliO, FliP, FliQ, and FliR proteins of Salmonella typhimurium:
RT   putative components for flagellar assembly.";
RL   J. Bacteriol. 179:6092-6099(1997).
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. Binds, with RcsB, to the RcsAB box to
CC       regulate expression of genes. {ECO:0000255|HAMAP-Rule:MF_00982}.
CC   -!- SUBUNIT: Interacts with RcsB. {ECO:0000255|HAMAP-Rule:MF_00982}.
CC   -!- SIMILARITY: Belongs to the RcsA family. {ECO:0000255|HAMAP-
CC       Rule:MF_00982}.
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DR   EMBL; AE006468; AAL20894.1; -; Genomic_DNA.
DR   EMBL; L49021; AAB81322.1; -; Genomic_DNA.
DR   PIR; S78701; S78701.
DR   RefSeq; NP_460935.1; NC_003197.2.
DR   RefSeq; WP_000103974.1; NC_003197.2.
DR   AlphaFoldDB; P54698; -.
DR   SMR; P54698; -.
DR   STRING; 99287.STM1982; -.
DR   PaxDb; P54698; -.
DR   EnsemblBacteria; AAL20894; AAL20894; STM1982.
DR   GeneID; 1253503; -.
DR   KEGG; stm:STM1982; -.
DR   PATRIC; fig|99287.12.peg.2099; -.
DR   HOGENOM; CLU_105065_0_0_6; -.
DR   OMA; ANIHFDE; -.
DR   PhylomeDB; P54698; -.
DR   BioCyc; SENT99287:STM1982-MON; -.
DR   PHI-base; PHI:3013; -.
DR   Proteomes; UP000001014; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00982; RcsA; 1.
DR   InterPro; IPR030866; RcsA.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Reference proteome; Sensory transduction; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..207
FT                   /note="Transcriptional regulatory protein RcsA"
FT                   /id="PRO_0000184181"
FT   DOMAIN          131..196
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00982"
FT   DNA_BIND        155..174
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00982"
SQ   SEQUENCE   207 AA;  23302 MW;  4DC34F8A11C66999 CRC64;
     MSTIIMDLCS YTRLGLSGYL VSRGVKKREI NDIETVDELA IACGAHQPSV VFINEDCFIH
     TPSDSQQIKQ IINQHPDTLF IVFMAIANVH FDEYLLVRKN LLISSKSIKP DSLDTLLGDI
     LKKESGISGT INLPTLSLSR TESSMLRMWM EGQGTIQISD RMNIKAKTVS SHKGNIKRKI
     KTHNKQVIYH VVRLTDNVTN GIFVNMR