ID   RCSB_ECOL6              Reviewed;         216 AA.
AC   P69408; P14374;
DT   01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   25-MAY-2022, entry version 100.
DE   RecName: Full=Transcriptional regulatory protein RcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN   Name=rcsB {ECO:0000255|HAMAP-Rule:MF_00981}; OrderedLocusNames=c2760;
OS   Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=199310;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CFT073 / ATCC 700928 / UPEC;
RX   PubMed=12471157; DOI=10.1073/pnas.252529799;
RA   Welch R.A., Burland V., Plunkett G. III, Redford P., Roesch P., Rasko D.,
RA   Buckles E.L., Liou S.-R., Boutin A., Hackett J., Stroud D., Mayhew G.F.,
RA   Rose D.J., Zhou S., Schwartz D.C., Perna N.T., Mobley H.L.T.,
RA   Donnenberg M.S., Blattner F.R.;
RT   "Extensive mosaic structure revealed by the complete genome sequence of
RT   uropathogenic Escherichia coli.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:17020-17024(2002).
CC   -!- FUNCTION: Component of the Rcs signaling system, which controls
CC       transcription of numerous genes. RcsB is the response regulator that
CC       binds to regulatory DNA regions. Can function both in an RcsA-dependent
CC       or RcsA-independent manner. {ECO:0000255|HAMAP-Rule:MF_00981}.
CC   -!- SUBUNIT: Interacts with RcsD and RcsA. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- PTM: Phosphorylated and activated by RcsD. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- SIMILARITY: Belongs to the RcsB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00981}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN81214.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE014075; AAN81214.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_001061917.1; NC_004431.1.
DR   AlphaFoldDB; P69408; -.
DR   SMR; P69408; -.
DR   STRING; 199310.c2760; -.
DR   EnsemblBacteria; AAN81214; AAN81214; c2760.
DR   GeneID; 67373623; -.
DR   KEGG; ecc:c2760; -.
DR   eggNOG; COG2197; Bacteria.
DR   HOGENOM; CLU_000445_90_1_6; -.
DR   OMA; TITMIDN; -.
DR   Proteomes; UP000001410; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-UniRule.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR   CDD; cd06170; LuxR_C_like; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   HAMAP; MF_00981; RcsB; 1.
DR   InterPro; IPR011006; CheY-like_superfamily.
DR   InterPro; IPR030864; RcsB.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR   InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF00196; GerE; 1.
DR   Pfam; PF00072; Response_reg; 1.
DR   PRINTS; PR00038; HTHLUXR.
DR   SMART; SM00421; HTH_LUXR; 1.
DR   SMART; SM00448; REC; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF52172; SSF52172; 1.
DR   PROSITE; PS00622; HTH_LUXR_1; 1.
DR   PROSITE; PS50043; HTH_LUXR_2; 1.
DR   PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW   Two-component regulatory system.
FT   CHAIN           1..216
FT                   /note="Transcriptional regulatory protein RcsB"
FT                   /id="PRO_0000081210"
FT   DOMAIN          5..124
FT                   /note="Response regulatory"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT   DOMAIN          144..209
FT                   /note="HTH luxR-type"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00981"
FT   DNA_BIND        168..187
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00981"
FT   MOD_RES         56
FT                   /note="4-aspartylphosphate"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00981"
SQ   SEQUENCE   216 AA;  23671 MW;  A78D1BD3004E0680 CRC64;
     MNNMNVIIAD DHPIVLFGIR KSLEQIEWVN VVGEFEDSTA LINNLPKLDA HVLITDLSMP
     GDKYGDGITL IKYIKRHFPS LSIIVLTMNN NPAILSAVLD LDIEGIVLKQ GAPTDLPKAL
     AALQKGKKFT PESVSRLLEK ISAGGYGDKR LSPKESEVLR LFAEGFLVTE IAKKLNRSIK
     TISSQKKSAM MKLGVENDIA LLNYLSSVTL SPADKD