RCSB_SALTI
ID RCSB_SALTI Reviewed; 216 AA.
AC Q56127;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 25-MAY-2022, entry version 140.
DE RecName: Full=Transcriptional regulatory protein RcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN Name=rcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN OrderedLocusNames=STY2495, t0595;
OS Salmonella typhi.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=90370;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=8626298; DOI=10.1128/jb.178.6.1691-1698.1996;
RA Virlogeux I., Waxin H., Ecobichon C., Lee J.O., Popoff M.Y.;
RT "Characterization of the rcsA and rcsB genes from Salmonella typhi: rcsB
RT through tviA is involved in regulation of Vi antigen synthesis.";
RL J. Bacteriol. 178:1691-1698(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=GIFU 10007;
RA Hashimoto Y.;
RL Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CT18;
RX PubMed=11677608; DOI=10.1038/35101607;
RA Parkhill J., Dougan G., James K.D., Thomson N.R., Pickard D., Wain J.,
RA Churcher C.M., Mungall K.L., Bentley S.D., Holden M.T.G., Sebaihia M.,
RA Baker S., Basham D., Brooks K., Chillingworth T., Connerton P., Cronin A.,
RA Davis P., Davies R.M., Dowd L., White N., Farrar J., Feltwell T.,
RA Hamlin N., Haque A., Hien T.T., Holroyd S., Jagels K., Krogh A.,
RA Larsen T.S., Leather S., Moule S., O'Gaora P., Parry C., Quail M.A.,
RA Rutherford K.M., Simmonds M., Skelton J., Stevens K., Whitehead S.,
RA Barrell B.G.;
RT "Complete genome sequence of a multiple drug resistant Salmonella enterica
RT serovar Typhi CT18.";
RL Nature 413:848-852(2001).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700931 / Ty2;
RX PubMed=12644504; DOI=10.1128/jb.185.7.2330-2337.2003;
RA Deng W., Liou S.-R., Plunkett G. III, Mayhew G.F., Rose D.J., Burland V.,
RA Kodoyianni V., Schwartz D.C., Blattner F.R.;
RT "Comparative genomics of Salmonella enterica serovar Typhi strains Ty2 and
RT CT18.";
RL J. Bacteriol. 185:2330-2337(2003).
CC -!- FUNCTION: Component of the Rcs signaling system, which controls
CC transcription of numerous genes. RcsB is the response regulator that
CC binds to regulatory DNA regions. Can function both in an RcsA-dependent
CC or RcsA-independent manner. {ECO:0000255|HAMAP-Rule:MF_00981}.
CC -!- SUBUNIT: Interacts with RcsD and RcsA. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- PTM: Phosphorylated and activated by RcsD. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- SIMILARITY: Belongs to the RcsB family. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
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DR EMBL; X87830; CAA61094.1; -; Genomic_DNA.
DR EMBL; AB000683; BAA19163.1; -; Genomic_DNA.
DR EMBL; AL513382; CAD07501.1; -; Genomic_DNA.
DR EMBL; AE014613; AAO68300.1; -; Genomic_DNA.
DR RefSeq; NP_456814.1; NC_003198.1.
DR RefSeq; WP_001061910.1; NZ_WSUR01000051.1.
DR AlphaFoldDB; Q56127; -.
DR SMR; Q56127; -.
DR STRING; 220341.16503496; -.
DR EnsemblBacteria; AAO68300; AAO68300; t0595.
DR KEGG; stt:t0595; -.
DR KEGG; sty:STY2495; -.
DR PATRIC; fig|220341.7.peg.2527; -.
DR eggNOG; COG2197; Bacteria.
DR HOGENOM; CLU_000445_90_1_6; -.
DR OMA; TITMIDN; -.
DR Proteomes; UP000000541; Chromosome.
DR Proteomes; UP000002670; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_00981; RcsB; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR030864; RcsB.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 3: Inferred from homology;
KW DNA-binding; Phosphoprotein; Transcription; Transcription regulation;
KW Two-component regulatory system.
FT CHAIN 1..216
FT /note="Transcriptional regulatory protein RcsB"
FT /id="PRO_0000081212"
FT DOMAIN 5..124
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 144..209
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00981"
FT DNA_BIND 168..187
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00981"
FT MOD_RES 56
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00981"
SQ SEQUENCE 216 AA; 23729 MW; D35CE2AB2B1DC0E4 CRC64;
MNNMNIIIAD DHPIVLFGIR KSLEQIEWVN VVGEFEDSTA LINNLPKLDA HVLITDLSMP
GDKYGDGITL IKYIKRHFPS LSIIVLTMNN NPAILSAVLD LDIEGIVLKQ GAPTDLPKAL
AALQKGKKFT PESVSRLLEK ISAGGYGDKR LSPKESEVLR LFAEGFLVTE IAKKLNRSIK
TISSQKKSAM MKLGVENDIA LLNYLSSVTL SPTDKE
