RCSB_SALTY
ID RCSB_SALTY Reviewed; 216 AA.
AC P58663;
DT 31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 31-JAN-2002, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Transcriptional regulatory protein RcsB {ECO:0000255|HAMAP-Rule:MF_00981};
GN Name=rcsB {ECO:0000255|HAMAP-Rule:MF_00981}; OrderedLocusNames=STM2270;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Component of the Rcs signaling system, which controls
CC transcription of numerous genes. RcsB is the response regulator that
CC binds to regulatory DNA regions. Can function both in an RcsA-dependent
CC or RcsA-independent manner. {ECO:0000255|HAMAP-Rule:MF_00981}.
CC -!- SUBUNIT: Interacts with RcsD and RcsA. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- PTM: Phosphorylated and activated by RcsD. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
CC -!- SIMILARITY: Belongs to the RcsB family. {ECO:0000255|HAMAP-
CC Rule:MF_00981}.
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DR EMBL; AE006468; AAL21171.1; -; Genomic_DNA.
DR RefSeq; NP_461212.1; NC_003197.2.
DR RefSeq; WP_001061919.1; NC_003197.2.
DR PDB; 5O8Y; X-ray; 2.30 A; A/C/D/F/G/H=1-216.
DR PDB; 5O8Z; X-ray; 2.10 A; A/B=1-216.
DR PDB; 6EO2; X-ray; 2.60 A; A=1-210.
DR PDB; 6EO3; X-ray; 2.50 A; A/B=1-210.
DR PDB; 6ZII; X-ray; 2.50 A; A/B=1-143.
DR PDB; 6ZIL; X-ray; 3.12 A; B=1-143.
DR PDB; 6ZIX; X-ray; 3.40 A; A/B=1-216.
DR PDB; 6ZJ2; X-ray; 3.38 A; A/B/C/D/L/M/N/O=1-216.
DR PDBsum; 5O8Y; -.
DR PDBsum; 5O8Z; -.
DR PDBsum; 6EO2; -.
DR PDBsum; 6EO3; -.
DR PDBsum; 6ZII; -.
DR PDBsum; 6ZIL; -.
DR PDBsum; 6ZIX; -.
DR PDBsum; 6ZJ2; -.
DR AlphaFoldDB; P58663; -.
DR SMR; P58663; -.
DR STRING; 99287.STM2270; -.
DR PaxDb; P58663; -.
DR EnsemblBacteria; AAL21171; AAL21171; STM2270.
DR GeneID; 1253792; -.
DR KEGG; stm:STM2270; -.
DR PATRIC; fig|99287.12.peg.2403; -.
DR HOGENOM; CLU_000445_90_1_6; -.
DR OMA; TITMIDN; -.
DR PhylomeDB; P58663; -.
DR BioCyc; SENT99287:STM2270-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:UniProtKB-UniRule.
DR CDD; cd06170; LuxR_C_like; 1.
DR Gene3D; 1.10.10.10; -; 1.
DR HAMAP; MF_00981; RcsB; 1.
DR InterPro; IPR011006; CheY-like_superfamily.
DR InterPro; IPR030864; RcsB.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR001789; Sig_transdc_resp-reg_receiver.
DR InterPro; IPR000792; Tscrpt_reg_LuxR_C.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR Pfam; PF00196; GerE; 1.
DR Pfam; PF00072; Response_reg; 1.
DR PRINTS; PR00038; HTHLUXR.
DR SMART; SM00421; HTH_LUXR; 1.
DR SMART; SM00448; REC; 1.
DR SUPFAM; SSF46894; SSF46894; 1.
DR SUPFAM; SSF52172; SSF52172; 1.
DR PROSITE; PS00622; HTH_LUXR_1; 1.
DR PROSITE; PS50043; HTH_LUXR_2; 1.
DR PROSITE; PS50110; RESPONSE_REGULATORY; 1.
PE 1: Evidence at protein level;
KW 3D-structure; DNA-binding; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation; Two-component regulatory system.
FT CHAIN 1..216
FT /note="Transcriptional regulatory protein RcsB"
FT /id="PRO_0000081213"
FT DOMAIN 5..124
FT /note="Response regulatory"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00169"
FT DOMAIN 144..209
FT /note="HTH luxR-type"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00981"
FT DNA_BIND 168..187
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00981"
FT MOD_RES 56
FT /note="4-aspartylphosphate"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00981"
FT STRAND 4..9
FT /evidence="ECO:0007829|PDB:5O8Z"
FT HELIX 13..24
FT /evidence="ECO:0007829|PDB:5O8Z"
FT STRAND 26..28
FT /evidence="ECO:0007829|PDB:6ZIX"
FT STRAND 29..37
FT /evidence="ECO:0007829|PDB:5O8Z"
FT HELIX 38..44
FT /evidence="ECO:0007829|PDB:5O8Z"
FT HELIX 45..47
FT /evidence="ECO:0007829|PDB:5O8Z"
FT STRAND 51..55
FT /evidence="ECO:0007829|PDB:5O8Z"
FT TURN 62..64
FT /evidence="ECO:0007829|PDB:5O8Z"
FT HELIX 67..77
FT /evidence="ECO:0007829|PDB:5O8Z"
FT STRAND 82..87
FT /evidence="ECO:0007829|PDB:5O8Z"
FT HELIX 92..100
FT /evidence="ECO:0007829|PDB:5O8Z"
FT STRAND 104..108
FT /evidence="ECO:0007829|PDB:5O8Z"
FT HELIX 109..111
FT /evidence="ECO:0007829|PDB:6EO3"
FT HELIX 115..125
FT /evidence="ECO:0007829|PDB:5O8Z"
FT HELIX 132..142
FT /evidence="ECO:0007829|PDB:5O8Z"
FT TURN 144..146
FT /evidence="ECO:0007829|PDB:5O8Y"
FT STRAND 147..149
FT /evidence="ECO:0007829|PDB:5O8Y"
FT HELIX 153..164
FT /evidence="ECO:0007829|PDB:5O8Z"
FT HELIX 168..173
FT /evidence="ECO:0007829|PDB:5O8Z"
FT HELIX 179..193
FT /evidence="ECO:0007829|PDB:5O8Z"
FT HELIX 198..208
FT /evidence="ECO:0007829|PDB:5O8Z"
SQ SEQUENCE 216 AA; 23715 MW; A63D1BCF704E0680 CRC64;
MNNMNVIIAD DHPIVLFGIR KSLEQIEWVN VVGEFEDSTA LINNLPKLDA HVLITDLSMP
GDKYGDGITL IKYIKRHFPS LSIIVLTMNN NPAILSAVLD LDIEGIVLKQ GAPTDLPKAL
AALQKGKKFT PESVSRLLEK ISAGGYGDKR LSPKESEVLR LFAEGFLVTE IAKKLNRSIK
TISSQKKSAM MKLGVENDIA LLNYLSSVTL SPTDKE
