ID   RD21L_AILME             Reviewed;         554 AA.
AC   D2HSB3;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Double-strand-break repair protein rad21-like protein 1;
GN   Name=RAD21L1; Synonyms=RAD21L; ORFNames=PANDA_014969;
OS   Ailuropoda melanoleuca (Giant panda).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Ursidae; Ailuropoda.
OX   NCBI_TaxID=9646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20010809; DOI=10.1038/nature08696;
RA   Li R., Fan W., Tian G., Zhu H., He L., Cai J., Huang Q., Cai Q., Li B.,
RA   Bai Y., Zhang Z., Zhang Y., Wang W., Li J., Wei F., Li H., Jian M., Li J.,
RA   Zhang Z., Nielsen R., Li D., Gu W., Yang Z., Xuan Z., Ryder O.A.,
RA   Leung F.C., Zhou Y., Cao J., Sun X., Fu Y., Fang X., Guo X., Wang B.,
RA   Hou R., Shen F., Mu B., Ni P., Lin R., Qian W., Wang G., Yu C., Nie W.,
RA   Wang J., Wu Z., Liang H., Min J., Wu Q., Cheng S., Ruan J., Wang M.,
RA   Shi Z., Wen M., Liu B., Ren X., Zheng H., Dong D., Cook K., Shan G.,
RA   Zhang H., Kosiol C., Xie X., Lu Z., Zheng H., Li Y., Steiner C.C.,
RA   Lam T.T., Lin S., Zhang Q., Li G., Tian J., Gong T., Liu H., Zhang D.,
RA   Fang L., Ye C., Zhang J., Hu W., Xu A., Ren Y., Zhang G., Bruford M.W.,
RA   Li Q., Ma L., Guo Y., An N., Hu Y., Zheng Y., Shi Y., Li Z., Liu Q.,
RA   Chen Y., Zhao J., Qu N., Zhao S., Tian F., Wang X., Wang H., Xu L., Liu X.,
RA   Vinar T., Wang Y., Lam T.W., Yiu S.M., Liu S., Zhang H., Li D., Huang Y.,
RA   Wang X., Yang G., Jiang Z., Wang J., Qin N., Li L., Li J., Bolund L.,
RA   Kristiansen K., Wong G.K., Olson M., Zhang X., Li S., Yang H., Wang J.,
RA   Wang J.;
RT   "The sequence and de novo assembly of the giant panda genome.";
RL   Nature 463:311-317(2010).
CC   -!- FUNCTION: Meiosis-specific component of some cohesin complex required
CC       during the initial steps of prophase I in male meiosis. Probably
CC       required during early meiosis in males for separation of sister
CC       chromatids and homologous chromosomes. Replaces RAD21 in premeiotic S
CC       phase (during early stages of prophase I), while RAD21 reappears in
CC       later stages of prophase I. Involved in synaptonemal complex assembly,
CC       synapsis initiation and crossover recombination between homologous
CC       chromosomes during prophase I (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of some meiotic cohesin complex composed of the SMC1
CC       (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain,
CC       RAD21L which link them, and STAG3. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:A2AU37}.
CC       Chromosome {ECO:0000250|UniProtKB:A2AU37}. Note=In meiotic chromosomes,
CC       localized along axial elements in early meiosis: detectable on the
CC       axial elements in leptotene, and stays on the axial/lateral elements
CC       until mid pachytene. It then disappears and is replaced with RAD21.
CC       Compared to REC8, has mutually exclusive loading sites on the
CC       chromosomes: REC8 and RAD21L form distinct cohesin-enriched domains
CC       along the axial elements. {ECO:0000250|UniProtKB:A2AU37}.
CC   -!- SIMILARITY: Belongs to the rad21 family. {ECO:0000305}.
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DR   EMBL; GL193270; EFB29591.1; -; Genomic_DNA.
DR   RefSeq; XP_002925456.1; XM_002925410.3.
DR   AlphaFoldDB; D2HSB3; -.
DR   PRIDE; D2HSB3; -.
DR   Ensembl; ENSAMET00000015544; ENSAMEP00000014930; ENSAMEG00000014153.
DR   GeneID; 100475087; -.
DR   CTD; 642636; -.
DR   InParanoid; D2HSB3; -.
DR   OrthoDB; 1253899at2759; -.
DR   Proteomes; UP000008912; Unassembled WGS sequence.
DR   GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR   GO; GO:0030893; C:meiotic cohesin complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0007062; P:sister chromatid cohesion; IEA:InterPro.
DR   Gene3D; 1.10.10.580; -; 1.
DR   InterPro; IPR039781; Rad21/Rec8-like.
DR   InterPro; IPR006909; Rad21/Rec8_C_eu.
DR   InterPro; IPR006910; Rad21_Rec8_N.
DR   InterPro; IPR023093; ScpA-like_C.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR12585; PTHR12585; 1.
DR   Pfam; PF04824; Rad21_Rec8; 1.
DR   Pfam; PF04825; Rad21_Rec8_N; 1.
DR   SUPFAM; SSF46785; SSF46785; 1.
PE   3: Inferred from homology;
KW   Chromosome; Chromosome partition; Meiosis; Nucleus; Reference proteome.
FT   CHAIN           1..554
FT                   /note="Double-strand-break repair protein rad21-like
FT                   protein 1"
FT                   /id="PRO_0000406974"
SQ   SEQUENCE   554 AA;  63039 MW;  5A3DA1C8C89EA105 CRC64;
     MFYTHVLMSK RGPLAKIWLA AHWEKKLTKA HVFECNLEIT IEKILSSKVK IALRTSGHLL
     LGVVRIYNRK AKYLLADCNE ALLKMKMTFR PGLVDLPKEN FEAAYNAITL PEEFHDFDTQ
     NVNAIDVSEH FTQNQSKPEE ITLREDYSND LLFQAGSFGE ETEILRRHSF FDDNILLNSS
     GPLVEHSSGS IAGEKPLFYD SEDGFGDEGA AGEMIDNLLQ DDQNILLEDS HLNREISLPP
     EPPDTIVVEP DNPEYIRLPE NGKMDETLSN EEEGFTLDPI DVSDIAEKRK AKKRKLLIDP
     IKEISSKIMH KQLTSFMDTL MVLELAPPTQ RLMMWKKKGG VDTLLSTAAQ DLTHAELKML
     FTKCFLSSGF KFGRKLMQKE SVREEVGSKN IVETSVMEEL NFQQDLNQSK TWKDVIDGSK
     CSSHEDINKN INSEQDIVEM VSSGTEESSS MNAILAQEIE NCTVELESSG NEQNIETERW
     NRRILQTLNS LRESNKMGMQ YFSLMKLCRN SDRKQAAAKF YSFLVLKKQQ AIELSQSDPY
     ADIIATVGPM FYKM