ID   RD2_PHYMI               Reviewed;         121 AA.
AC   G3KFL3;
DT   05-JUN-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 1.
DT   25-MAY-2022, entry version 15.
DE   RecName: Full=RxLR effector protein PexRD2 {ECO:0000303|PubMed:21813644};
DE   Flags: Precursor;
GN   Name=PexRD2 {ECO:0000303|PubMed:21813644};
OS   Phytophthora mirabilis.
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=129356;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DOMAIN.
RC   STRAIN=PIC 99114;
RX   PubMed=21813644; DOI=10.1074/jbc.m111.262303;
RA   Boutemy L.S., King S.R., Win J., Hughes R.K., Clarke T.A.,
RA   Blumenschein T.M., Kamoun S., Banfield M.J.;
RT   "Structures of Phytophthora RXLR effector proteins: a conserved but
RT   adaptable fold underpins functional diversity.";
RL   J. Biol. Chem. 286:35834-35842(2011).
CC   -!- FUNCTION: Secreted effector involved in P.mirabilis colonization of
CC       host plants (Probable). May perturb the signaling of cell death
CC       associated with plant immunity, via interaction with a host MAP kinase
CC       (Probable). {ECO:0000305|PubMed:21813644}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:D0NIN5}. Host
CC       cytoplasm {ECO:0000250|UniProtKB:D0NIN5}. Host nucleus
CC       {ECO:0000250|UniProtKB:D0NIN5}.
CC   -!- DOMAIN: The RxLR-dEER motif acts to carry the protein into the host
CC       cell cytoplasm through binding to cell surface phosphatidylinositol-3-
CC       phosphate. {ECO:0000305|PubMed:21813644}.
CC   -!- DOMAIN: The WY domain contains 3 alpha-helices and is required for the
CC       interaction with a host MAP kinase. {ECO:0000305|PubMed:21813644}.
CC   -!- SIMILARITY: Belongs to the RxLR effector family. {ECO:0000305}.
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DR   EMBL; JN208877; AEO72328.1; -; Genomic_DNA.
DR   AlphaFoldDB; G3KFL3; -.
DR   SMR; G3KFL3; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR040691; PexRD2_WYL.
DR   Pfam; PF18488; WYL_3; 1.
PE   3: Inferred from homology;
KW   Host cytoplasm; Host nucleus; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..121
FT                   /note="RxLR effector protein PexRD2"
FT                   /id="PRO_5003446717"
FT   REGION          57..121
FT                   /note="WY domain"
FT                   /evidence="ECO:0000305|PubMed:21813644"
FT   MOTIF           38..56
FT                   /note="RxLR-dEER"
FT                   /evidence="ECO:0000305|PubMed:21813644"
SQ   SEQUENCE   121 AA;  13188 MW;  C6B52D9232CB1561 CRC64;
     MRLSYVFVVF AASLLVTADT LSTNTGVQAA NLVGPAQRLL RKHYTAAEND GDSEARALNP
     EKMKTMWKAG MTVDGYAAKL KLTDKIAAAA NSAKAMEKLG ETHKMKKLLR YLNYVAEHTA
     V