ID   RDC3_METCM              Reviewed;         539 AA.
AC   B3FWT8;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 35.
DE   RecName: Full=Efflux pump rdc3 {ECO:0000303|PubMed:18567690};
DE   AltName: Full=Hypothemycin biosynthesis cluster protein rdc3 {ECO:0000303|PubMed:18567690};
GN   Name=rdc3 {ECO:0000303|PubMed:18567690};
OS   Metacordyceps chlamydosporia (Nematophagous fungus) (Pochonia
OS   chlamydosporia).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Clavicipitaceae; Pochonia.
OX   NCBI_TaxID=280754;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 16683;
RX   PubMed=18567690; DOI=10.1128/aem.00478-08;
RA   Reeves C.D., Hu Z., Reid R., Kealey J.T.;
RT   "Genes for the biosynthesis of the fungal polyketides hypothemycin from
RT   Hypomyces subiculosus and radicicol from Pochonia chlamydosporia.";
RL   Appl. Environ. Microbiol. 74:5121-5129(2008).
CC   -!- FUNCTION: Efflux pump that might be required for efficient secretion of
CC       radicicol or other secondary metabolies produced by the radicicol gene
CC       cluster (PubMed:18567690). {ECO:0000269|PubMed:18567690}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily.
CC       {ECO:0000305}.
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DR   EMBL; EU520419; ACD39772.1; -; Genomic_DNA.
DR   AlphaFoldDB; B3FWT8; -.
DR   SMR; B3FWT8; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Glycoprotein; Membrane; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..539
FT                   /note="Efflux pump rdc3"
FT                   /id="PRO_0000437619"
FT   TRANSMEM        100..120
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        135..155
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        173..193
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        195..215
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        227..247
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        254..274
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        328..348
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..383
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        410..430
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        438..458
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        473..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        506..526
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..55
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        56..73
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        60
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        99
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        132
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   539 AA;  58675 MW;  9D468D94CD30A957 CRC64;
     MAPSQDLGER DQQQPPAPYP ADLENGRYGR IPNGHGSTTG TEGSGTLQLN EKDDATLRPN
     GSHDVKEEGQ ETSTNVVDWD GPDDPANPQN WTLSKKWLNI SVVGLITFNV PLASSMFAPA
     VPQLLQDFHT DNASLSTFVV SVYILGLAAG PLILAPMSEL YGRLNVYHVG NVLFIIFTVA
     CGLATNINML VAFRFLAGLV GAAPIAIGAG TIADVTNLQQ RGTAMSIWSL GPLLGPSIGP
     VIGGFLAQAA GWRWIFWLLA IIAGAVAIIS FFVLQETHAP TLLKRKTNRL RKETGNMALR
     SKLDTQLPPK EMFLRAIVRP CKMLLFSPVC LILSFYSAFV YALIYFMFST FSFIFKASYG
     FNQGTVGLVY LACGIGMLLG LGIQQLTGDR IRQRLADKRN GGDHKPEYRF PPMFMAGGLL
     PAGLFMYGWA VQHHVQWAVP LLGTLIAGIG ICIISICINT YLVDTFTMYA ASALAASAVL
     RSVFAAVLPL FALQMYNKLG LGWGNSLLAF VGLGMWPITF LFFVHGEKLR KNPKFQIKF