ID   RDE11_CAEEL             Reviewed;         316 AA.
AC   Q6BET5;
DT   11-NOV-2015, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=RNA interference defective protein 11 {ECO:0000312|WormBase:B0564.11};
GN   Name=rde-11 {ECO:0000312|WormBase:B0564.11};
GN   ORFNames=B0564.11 {ECO:0000312|WormBase:B0564.11};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH RDE-10, DISRUPTION PHENOTYPE, AND IDENTIFICATION
RP   BY MASS SPECTROMETRY.
RX   PubMed=22542102; DOI=10.1016/j.cub.2012.04.011;
RA   Zhang C., Montgomery T.A., Fischer S.E., Garcia S.M., Riedel C.G.,
RA   Fahlgren N., Sullivan C.M., Carrington J.C., Ruvkun G.;
RT   "The Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by
RT   promoting secondary siRNA amplification.";
RL   Curr. Biol. 22:881-890(2012).
RN   [3] {ECO:0000305}
RP   FUNCTION, INTERACTION WITH RDE-10, AND MUTAGENESIS OF CYS-203.
RX   PubMed=22508728; DOI=10.1101/gad.180679.111;
RA   Yang H., Zhang Y., Vallandingham J., Li H., Li H., Florens L., Mak H.Y.;
RT   "The RDE-10/RDE-11 complex triggers RNAi-induced mRNA degradation by
RT   association with target mRNA in C. elegans.";
RL   Genes Dev. 26:846-856(2012).
CC   -!- FUNCTION: In complex with rde-10, required in the endogenous and
CC       exogenous siRNA pathway for biogenesis and accumulation of secondary
CC       small interfering RNA (siRNA) intermediates, such as 22G-siRNAs derived
CC       from ergo-1 targets. {ECO:0000269|PubMed:22508728,
CC       ECO:0000269|PubMed:22542102}.
CC   -!- SUBUNIT: Interacts (via RING-type zinc finger domain) with rde-10.
CC       {ECO:0000269|PubMed:22508728, ECO:0000269|PubMed:22542102}.
CC   -!- DISRUPTION PHENOTYPE: Insensitive to RNAi-mediated gene silencing.
CC       {ECO:0000269|PubMed:22542102}.
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DR   EMBL; BX284604; CAH04641.1; -; Genomic_DNA.
DR   RefSeq; NP_001021278.1; NM_001026107.6.
DR   AlphaFoldDB; Q6BET5; -.
DR   ComplexPortal; CPX-1000; Rde-10/Rde-11 complex.
DR   STRING; 6239.B0564.11.2; -.
DR   EPD; Q6BET5; -.
DR   PaxDb; Q6BET5; -.
DR   PeptideAtlas; Q6BET5; -.
DR   EnsemblMetazoa; B0564.11.1; B0564.11.1; WBGene00023421.
DR   EnsemblMetazoa; B0564.11.2; B0564.11.2; WBGene00023421.
DR   GeneID; 3565977; -.
DR   KEGG; cel:CELE_B0564.11; -.
DR   UCSC; B0564.11; c. elegans.
DR   CTD; 3565977; -.
DR   WormBase; B0564.11; CE36970; WBGene00023421; rde-11.
DR   eggNOG; ENOG502TI3I; Eukaryota.
DR   GeneTree; ENSGT00390000008228; -.
DR   HOGENOM; CLU_937639_0_0_1; -.
DR   InParanoid; Q6BET5; -.
DR   OrthoDB; 963530at2759; -.
DR   PRO; PR:Q6BET5; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00023421; Expressed in germ line (C elegans) and 4 other tissues.
DR   GO; GO:0031332; C:RNAi effector complex; IC:ComplexPortal.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0031047; P:gene silencing by RNA; IEA:UniProtKB-KW.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.40.10; -; 1.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   1: Evidence at protein level;
KW   Metal-binding; Reference proteome; Repressor; RNA-mediated gene silencing;
KW   Translation regulation; Zinc; Zinc-finger.
FT   CHAIN           1..316
FT                   /note="RNA interference defective protein 11"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000434616"
FT   ZN_FING         183..218
FT                   /note="RING-type; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   MUTAGEN         203
FT                   /note="C->S: Impaired interaction with rde-10."
FT                   /evidence="ECO:0000269|PubMed:22508728"
SQ   SEQUENCE   316 AA;  36416 MW;  BDD415D8B9FB8E88 CRC64;
     MNVITPPFAD GVDPKPVCIV ADDIFETMTA RRKIHFSIYV IFKKNVELAE PFKLLYYTEK
     KNVAHLDGSV AQDFGLPMWT KDDGQRAPDL SRQKNDYIKL DFFTNINNPE DGFSYCWTDC
     ISTKNTTMVP RQLMPPSKRS MKLYLILPVE ESNIMVLSEK AYGSLQLMKK HRKMGQPPQR
     VGCYINFNCQ TSKVMFGCGH VYCEQCLNSW NDKPCSVCLK PVTSEPTQLK LRQGPCPFDL
     CSPNSSTMGI VLIPCGCHVM CQNLEDAYER NKHHLEPLIE KIKYCPFEPC RIRVRKLKKP
     FWHQQDKEHT LEMNSA