AAEX_ECOLI
ID AAEX_ECOLI Reviewed; 67 AA.
AC P46478; Q2M8X1;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Protein AaeX {ECO:0000255|HAMAP-Rule:MF_01546};
GN Name=aaeX {ECO:0000255|HAMAP-Rule:MF_01546}; Synonyms=yhcR;
GN OrderedLocusNames=b3242, JW5541;
OS Escherichia coli (strain K12).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Escherichia.
OX NCBI_TaxID=83333;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=9278503; DOI=10.1126/science.277.5331.1453;
RA Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
RA Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
RA Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B.,
RA Shao Y.;
RT "The complete genome sequence of Escherichia coli K-12.";
RL Science 277:1453-1462(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
RX PubMed=16738553; DOI=10.1038/msb4100049;
RA Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
RA Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
RT "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655
RT and W3110.";
RL Mol. Syst. Biol. 2:E1-E5(2006).
RN [3]
RP INDUCTION.
RC STRAIN=K12 / MG1655 / ATCC 47076;
RX PubMed=15489430; DOI=10.1128/jb.186.21.7196-7204.2004;
RA Van Dyk T.K., Templeton L.J., Cantera K.A., Sharpe P.L., Sariaslani F.S.;
RT "Characterization of the Escherichia coli AaeAB efflux pump: a metabolic
RT relief valve?";
RL J. Bacteriol. 186:7196-7204(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01546};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_01546}.
CC -!- INDUCTION: Positively coregulated with aaeA and aaeB by AaeR.
CC {ECO:0000255|HAMAP-Rule:MF_01546, ECO:0000269|PubMed:15489430}.
CC -!- SIMILARITY: Belongs to the AaeX family. {ECO:0000255|HAMAP-
CC Rule:MF_01546}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA58044.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; U18997; AAA58044.1; ALT_INIT; Genomic_DNA.
DR EMBL; U00096; AAC76274.2; -; Genomic_DNA.
DR EMBL; AP009048; BAE77285.1; -; Genomic_DNA.
DR PIR; D65116; D65116.
DR RefSeq; NP_417709.2; NC_000913.3.
DR RefSeq; WP_000051841.1; NZ_STEB01000012.1.
DR AlphaFoldDB; P46478; -.
DR BioGRID; 4262440; 13.
DR STRING; 511145.b3242; -.
DR PaxDb; P46478; -.
DR EnsemblBacteria; AAC76274; AAC76274; b3242.
DR EnsemblBacteria; BAE77285; BAE77285; BAE77285.
DR GeneID; 67415926; -.
DR GeneID; 947751; -.
DR KEGG; ecj:JW5541; -.
DR KEGG; eco:b3242; -.
DR PATRIC; fig|1411691.4.peg.3486; -.
DR EchoBASE; EB2675; -.
DR eggNOG; ENOG5032YJX; Bacteria.
DR HOGENOM; CLU_188292_0_0_6; -.
DR OMA; IYDLVWH; -.
DR PhylomeDB; P46478; -.
DR BioCyc; EcoCyc:G7687-MON; -.
DR PRO; PR:P46478; -.
DR Proteomes; UP000000318; Chromosome.
DR Proteomes; UP000000625; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR HAMAP; MF_01546; AaeX; 1.
DR InterPro; IPR012451; DUF1656.
DR Pfam; PF07869; DUF1656; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..67
FT /note="Protein AaeX"
FT /id="PRO_0000215048"
FT TRANSMEM 3..23
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01546"
FT TRANSMEM 43..63
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01546"
SQ SEQUENCE 67 AA; 7847 MW; FE90E26EC56C9183 CRC64;
MSLFPVIVVF GLSFPPIFFE LLLSLAIFWL VRRVLVPTGI YDFVWHPALF NTALYCCLFY
LISRLFV
