RDH10_RAT
ID RDH10_RAT Reviewed; 341 AA.
AC Q80ZF7;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Retinol dehydrogenase 10;
DE EC=1.1.1.300;
GN Name=Rdh10;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Retina;
RX PubMed=15505029; DOI=10.1167/iovs.03-1302;
RA Wu B.X., Moiseyev G., Chen Y., Rohrer B., Crouch R.K., Ma J.-X.;
RT "Identification of RDH10, an all-trans retinol dehydrogenase, in retinal
RT Mueller cells.";
RL Invest. Ophthalmol. Vis. Sci. 45:3857-3862(2004).
CC -!- FUNCTION: Retinol dehydrogenase with a clear preference for NADP.
CC Converts all-trans-retinol to all-trans-retinal.
CC {ECO:0000269|PubMed:15505029}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=all-trans-retinol + NADP(+) = all-trans-retinal + H(+) +
CC NADPH; Xref=Rhea:RHEA:25033, ChEBI:CHEBI:15378, ChEBI:CHEBI:17336,
CC ChEBI:CHEBI:17898, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.300;
CC -!- PATHWAY: Cofactor metabolism; retinol metabolism.
CC -!- SUBCELLULAR LOCATION: Microsome membrane {ECO:0000305}; Single-pass
CC membrane protein {ECO:0000305}. Endoplasmic reticulum membrane
CC {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Detected in retina, entire eyecups and in liver (at
CC protein level). {ECO:0000269|PubMed:15505029}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000305}.
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DR EMBL; AY178865; AAO31688.1; -; mRNA.
DR RefSeq; NP_852143.1; NM_181478.2.
DR AlphaFoldDB; Q80ZF7; -.
DR SMR; Q80ZF7; -.
DR STRING; 10116.ENSRNOP00000009096; -.
DR PaxDb; Q80ZF7; -.
DR Ensembl; ENSRNOT00000009096; ENSRNOP00000009096; ENSRNOG00000006681.
DR GeneID; 353252; -.
DR KEGG; rno:353252; -.
DR UCSC; RGD:727793; rat.
DR CTD; 157506; -.
DR RGD; 727793; Rdh10.
DR eggNOG; KOG1201; Eukaryota.
DR GeneTree; ENSGT00940000157063; -.
DR HOGENOM; CLU_010194_2_5_1; -.
DR InParanoid; Q80ZF7; -.
DR OMA; VCTPRII; -.
DR OrthoDB; 1373099at2759; -.
DR PhylomeDB; Q80ZF7; -.
DR TreeFam; TF312837; -.
DR Reactome; R-RNO-2453902; The canonical retinoid cycle in rods (twilight vision).
DR Reactome; R-RNO-5365859; RA biosynthesis pathway.
DR UniPathway; UPA00912; -.
DR PRO; PR:Q80ZF7; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000006681; Expressed in liver and 19 other tissues.
DR Genevisible; Q80ZF7; RN.
DR GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; ISO:RGD.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IDA:RGD.
DR GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0004745; F:NAD-retinol dehydrogenase activity; ISO:RGD.
DR GO; GO:0052650; F:NADP-retinol dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0009887; P:animal organ morphogenesis; ISO:RGD.
DR GO; GO:0060449; P:bud elongation involved in lung branching; ISO:RGD.
DR GO; GO:0043583; P:ear development; ISO:RGD.
DR GO; GO:0031076; P:embryonic camera-type eye development; ISO:RGD.
DR GO; GO:0035115; P:embryonic forelimb morphogenesis; ISO:RGD.
DR GO; GO:0048568; P:embryonic organ development; ISO:RGD.
DR GO; GO:0048703; P:embryonic viscerocranium morphogenesis; ISO:RGD.
DR GO; GO:0008406; P:gonad development; ISO:RGD.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0001656; P:metanephros development; ISO:RGD.
DR GO; GO:0014032; P:neural crest cell development; ISO:RGD.
DR GO; GO:0043584; P:nose development; ISO:RGD.
DR GO; GO:1900054; P:positive regulation of retinoic acid biosynthetic process; IMP:RGD.
DR GO; GO:0060431; P:primary lung bud formation; ISO:RGD.
DR GO; GO:0042574; P:retinal metabolic process; ISO:RGD.
DR GO; GO:0002138; P:retinoic acid biosynthetic process; ISO:RGD.
DR GO; GO:0042572; P:retinol metabolic process; ISO:RGD.
DR GO; GO:0007601; P:visual perception; ISO:RGD.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032970; RDH10.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR24322:SF731; PTHR24322:SF731; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; SSF51735; 1.
DR PROSITE; PS00061; ADH_SHORT; 1.
PE 1: Evidence at protein level;
KW Endoplasmic reticulum; Lipid metabolism; Membrane; Microsome; NADP;
KW Oxidoreductase; Reference proteome; Signal-anchor; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..341
FT /note="Retinol dehydrogenase 10"
FT /id="PRO_0000307684"
FT TRANSMEM 3..23
FT /note="Helical; Signal-anchor"
FT /evidence="ECO:0000255"
FT ACT_SITE 210
FT /note="Proton acceptor"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU10001"
FT BINDING 40..64
FT /ligand="NADP(+)"
FT /ligand_id="ChEBI:CHEBI:58349"
FT /evidence="ECO:0000250"
FT BINDING 197
FT /ligand="substrate"
FT /evidence="ECO:0000250"
SQ SEQUENCE 341 AA; 38061 MW; 4DEFBE03B3561690 CRC64;
MNIVVEFFLV TFKVLWAFVL AAARWLVRPK EKSVAGQVCL ITGAGSGLGR LFALEFARRR
ALLVLWDINT QSNEETAGMV RHIYRDLEAA DAAALQAGNG EEEILPPCNL QVFTYTCDVG
KRENVYLTAE RVRKEVGEVS VLVNNAGVVS GHHLLECPDE LIERTMMVNC HAHFWTTKAF
LPTMLEINHG HIVTVASSLG LFSTAGVEDY CASKFGVVGF HESLSHELKA AEKDGIKTTL
VCPYLVDTGM FRGCRIRKEI EPFLPPLKPD YCVKQAMKAI LTDQPMICTP RLMYIVTFMK
SILPFEAVVC MYRFLGADKC MYPFIAQRKQ ATNNNEAKNG I
