ID   RDM1_MACFA              Reviewed;         284 AA.
AC   Q4R856;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=RAD52 motif-containing protein 1;
GN   Name=RDM1; ORFNames=QtsA-13416;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May confer resistance to the antitumor agent cisplatin. Binds
CC       to DNA and RNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Nucleus, nucleolus. Nucleus,
CC       Cajal body. Nucleus, PML body. Note=After treatment with proteasomal
CC       inhibitors and mild heat-shock stress is relocalized to the nucleolus
CC       as dot-like or irregular subnuclear structures. Colocalized with
CC       nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this
CC       association with nuclear bodies is enhanced in response to proteotoxic
CC       stress. Relocalized in nucleolar caps during transcriptional arrest (By
CC       similarity). {ECO:0000250}.
CC   -!- DOMAIN: C-terminal half contains cytoplasmic retention domains as well
CC       as determinants involved in its stress-induced nucleolar accumulation.
CC       {ECO:0000250}.
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DR   EMBL; AB168602; BAE00716.1; -; mRNA.
DR   RefSeq; NP_001272199.1; NM_001285270.1.
DR   AlphaFoldDB; Q4R856; -.
DR   SMR; Q4R856; -.
DR   STRING; 9541.XP_005583546.1; -.
DR   Ensembl; ENSMFAT00000070553; ENSMFAP00000019999; ENSMFAG00000032968.
DR   GeneID; 102131438; -.
DR   CTD; 201299; -.
DR   VEuPathDB; HostDB:ENSMFAG00000032968; -.
DR   eggNOG; ENOG502RXM9; Eukaryota.
DR   GeneTree; ENSGT00390000018397; -.
DR   OMA; PAYECRS; -.
DR   OrthoDB; 1475838at2759; -.
DR   Proteomes; UP000233100; Chromosome 16.
DR   Bgee; ENSMFAG00000032968; Expressed in bone marrow and 9 other tissues.
DR   GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006259; P:DNA metabolic process; IEA:UniProt.
DR   CDD; cd12364; RRM_RDM1; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR041247; Rad52_fam.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR040224; RDM1.
DR   InterPro; IPR034200; RDM1_RRM.
DR   InterPro; IPR000504; RRM_dom.
DR   PANTHER; PTHR31164; PTHR31164; 1.
DR   Pfam; PF04098; Rad52_Rad22; 1.
DR   Pfam; PF00076; RRM_1; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
DR   PROSITE; PS50102; RRM; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; DNA-binding; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..284
FT                   /note="RAD52 motif-containing protein 1"
FT                   /id="PRO_0000299529"
FT   DOMAIN          15..98
FT                   /note="RRM"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT   REGION          1..92
FT                   /note="Necessary for nuclear localization and for nucleolar
FT                   accumulation in response to heat shock"
FT                   /evidence="ECO:0000250"
FT   REGION          90..133
FT                   /note="Necessary for nuclear and nucleolar localization"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   284 AA;  32269 MW;  C035E222AA801EFB CRC64;
     MAELVPFAVP IESDKTLLVW ELSSGPTAEA LHHSLFTAFS QFGLLYSVRV FPNAAVAHPG
     FYAVIKFYSA RAARRAQKAC DRKQLFQKSP VKVRLGTRHK AVQHQALALN SSRCQELANY
     YFGFNGWSKR IIKLQELSDL EERENEDSMV PLPKQSLKFF CALEVMLPSY DCRSPGVGLV
     EKPVDKVEEG PLSFLMKRKT AQKLAIQKAL SDAFQKLLIV VLESGKIAVE YRPSEDIIDV
     RCEEELHGLI QVHCSPWKQC GQEEEEYLSD FSLEEEEFRL PELD