RDM1_MOUSE
ID RDM1_MOUSE Reviewed; 281 AA.
AC Q9CQK3;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=RAD52 motif-containing protein 1;
GN Name=Rdm1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic stem cell, and Heart;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May confer resistance to the antitumor agent cisplatin. Binds
CC to DNA and RNA (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Nucleus, nucleolus. Nucleus,
CC Cajal body. Nucleus, PML body. Note=After treatment with proteasomal
CC inhibitors and mild heat-shock stress is relocalized to the nucleolus
CC as dot-like or irregular subnuclear structures. Colocalized with
CC nuclear promyelocytic leukemia (PML) and Cajal bodies (CB); this
CC association with nuclear bodies is enhanced in response to proteotoxic
CC stress. Relocalized in nucleolar caps during transcriptional arrest (By
CC similarity). {ECO:0000250}.
CC -!- DOMAIN: C-terminal half contains cytoplasmic retention domains as well
CC as determinants involved in its stress-induced nucleolar accumulation.
CC {ECO:0000250}.
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DR EMBL; AK003135; BAB22595.1; -; mRNA.
DR EMBL; AK010457; BAB26954.1; -; mRNA.
DR EMBL; AL590994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026811; AAH26811.1; -; mRNA.
DR EMBL; BC055013; AAH55013.1; -; mRNA.
DR CCDS; CCDS25477.1; -.
DR RefSeq; NP_079930.1; NM_025654.2.
DR AlphaFoldDB; Q9CQK3; -.
DR BioGRID; 211585; 1.
DR IntAct; Q9CQK3; 1.
DR MINT; Q9CQK3; -.
DR STRING; 10090.ENSMUSP00000010506; -.
DR PhosphoSitePlus; Q9CQK3; -.
DR PaxDb; Q9CQK3; -.
DR PRIDE; Q9CQK3; -.
DR ProteomicsDB; 253193; -.
DR Antibodypedia; 73933; 117 antibodies from 22 providers.
DR Ensembl; ENSMUST00000010506; ENSMUSP00000010506; ENSMUSG00000010362.
DR GeneID; 66599; -.
DR KEGG; mmu:66599; -.
DR UCSC; uc007lpp.1; mouse.
DR CTD; 201299; -.
DR MGI; MGI:1913849; Rdm1.
DR VEuPathDB; HostDB:ENSMUSG00000010362; -.
DR eggNOG; ENOG502RXM9; Eukaryota.
DR GeneTree; ENSGT00390000018397; -.
DR HOGENOM; CLU_085746_1_0_1; -.
DR InParanoid; Q9CQK3; -.
DR OMA; PAYECRS; -.
DR OrthoDB; 1475838at2759; -.
DR PhylomeDB; Q9CQK3; -.
DR TreeFam; TF101222; -.
DR BioGRID-ORCS; 66599; 5 hits in 74 CRISPR screens.
DR PRO; PR:Q9CQK3; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9CQK3; protein.
DR Bgee; ENSMUSG00000010362; Expressed in interventricular septum and 169 other tissues.
DR ExpressionAtlas; Q9CQK3; baseline and differential.
DR Genevisible; Q9CQK3; MM.
DR GO; GO:0015030; C:Cajal body; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0016605; C:PML body; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR CDD; cd12364; RRM_RDM1; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR040224; RDM1.
DR InterPro; IPR034200; RDM1_RRM.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR31164; PTHR31164; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; SSF54928; 1.
DR PROSITE; PS50102; RRM; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..281
FT /note="RAD52 motif-containing protein 1"
FT /id="PRO_0000299530"
FT DOMAIN 15..98
FT /note="RRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00176"
FT REGION 1..92
FT /note="Necessary for nuclear localization and for nucleolar
FT accumulation in response to heat shock"
FT /evidence="ECO:0000250"
FT REGION 90..133
FT /note="Necessary for nuclear and nucleolar localization"
FT /evidence="ECO:0000250"
SQ SEQUENCE 281 AA; 31235 MW; 7FDB5CB5F2579CCE CRC64;
MAELISFVVP TQSDKVLLVW DLSTGPPAEA LSHSLFTVFS QFGLLYSVRV FPNAAVARPG
FYAIIKFYSS RDAQRAQKAC DGKPLFQTSP VKVRLGTRHK ALQHQAFALN SSRCQELANY
YFGFSGWSKR IIKLQELSGL EDAALAVPMQ KGSPQFLCAV EVVLPPYGCR SPGVGISEEP
LRQLEEGQSS FLMKRKTAQK LAFQAAVSDA FQKLTIVVLE SGRIAVEYRP TAEDLDARSE
EELQNLIQVS CSSWSQSSQR EEECLSDFSL EEEDLKLCDP H
