ID   RDR1_ORYSJ              Reviewed;         740 AA.
AC   Q0DXS3; A0A0P0VPF0;
DT   07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Probable RNA-dependent RNA polymerase 1;
DE            Short=OsRDR1;
DE            EC=2.7.7.48;
GN   Name=RDR1; OrderedLocusNames=Os02g0736200, LOC_Os02g50330;
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-449.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=12869764; DOI=10.1126/science.1081288;
RG   The rice full-length cDNA consortium;
RT   "Collection, mapping, and annotation of over 28,000 cDNA clones from
RT   japonica rice.";
RL   Science 301:376-379(2003).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18826656; DOI=10.1186/1471-2164-9-451;
RA   Kapoor M., Arora R., Lama T., Nijhawan A., Khurana J.P., Tyagi A.K.,
RA   Kapoor S.;
RT   "Genome-wide identification, organization and phylogenetic analysis of
RT   dicer-like, argonaute and RNA-dependent RNA polymerase gene families and
RT   their expression analysis during reproductive development and stress in
RT   rice.";
RL   BMC Genomics 9:451-451(2008).
CC   -!- FUNCTION: Probably involved in the RNA silencing pathway and required
CC       for the generation of small interfering RNAs (siRNAs). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48;
CC   -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAF09965.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AP008208; BAF09965.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AP014958; BAS80805.1; -; Genomic_DNA.
DR   EMBL; AK101440; -; NOT_ANNOTATED_CDS; mRNA.
DR   AlphaFoldDB; Q0DXS3; -.
DR   SMR; Q0DXS3; -.
DR   STRING; 39947.Q0DXS3; -.
DR   PaxDb; Q0DXS3; -.
DR   PRIDE; Q0DXS3; -.
DR   EnsemblPlants; Os02t0736200-01; Os02t0736200-01; Os02g0736200.
DR   Gramene; Os02t0736200-01; Os02t0736200-01; Os02g0736200.
DR   InParanoid; Q0DXS3; -.
DR   Proteomes; UP000000763; Chromosome 2.
DR   Proteomes; UP000059680; Chromosome 2.
DR   GO; GO:0031380; C:nuclear RNA-directed RNA polymerase complex; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IBA:GO_Central.
DR   GO; GO:0060148; P:positive regulation of post-transcriptional gene silencing; IEA:EnsemblPlants.
DR   GO; GO:0009751; P:response to salicylic acid; IEA:EnsemblPlants.
DR   GO; GO:0009615; P:response to virus; IEA:EnsemblPlants.
DR   GO; GO:0030422; P:siRNA processing; IBA:GO_Central.
DR   GO; GO:0010025; P:wax biosynthetic process; IEA:EnsemblPlants.
DR   InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR   PANTHER; PTHR23079; PTHR23079; 1.
DR   Pfam; PF05183; RdRP; 1.
PE   2: Evidence at transcript level;
KW   Nucleotidyltransferase; Reference proteome; RNA-binding;
KW   RNA-directed RNA polymerase; RNA-mediated gene silencing; Transferase.
FT   CHAIN           1..740
FT                   /note="Probable RNA-dependent RNA polymerase 1"
FT                   /id="PRO_0000378445"
SQ   SEQUENCE   740 AA;  84255 MW;  41CE2AE2E781232E CRC64;
     MMDWFMSTVY FYGPEINVSN RVVRNFSSDI ENFLRISFVD EDCEKLRATD LSPRSASGHD
     ANRTALYKRV LSVLSDGITI GGKNFEFLAF SSSQLRDNSA WMFASRQGLA ASDIRTWMGD
     FRNIRNVAKY AARLGQSFSS STETLKVQKY EVEEISDIKN GTQHVFSDGI GKISSAFANE
     VAMKCNLKRF APSAFQIRYG GYKGVVAVDP TSRWKLSLRK SMLKFQSDNI TVDVLAYSKY
     QPGFLNRQLI TLLSTLGVRD SVFEQKQEEA VNQLNKMVTD PQAAIEAIEL MPMGEITNAV
     KELLLCGYQP DDEPYLSMLL QTFRASKLLE LKTKSRILIP KGRAMMGCLD ETRTLKYGQV
     FIRATSGVND NDRFTVTGKV VIAKNPCLHP GDIRILHAVD VPVLHHMFNC VVFPQQGPRP
     HPNECSGSDL DGDIYFVSWD PSLIPPRMVT PMDYTPAPTE TLDHDVTIEE VEEYFTNYIV
     NESLGMIANA HVVFADKEDL KAESSPCIEL AKLFSIAVDF PKTGVPALIP PELHVKEYPD
     FMEKLDKVTY ESKGVIGKLY REIKKHTPHI KHFTREVARR SYDTDMIVDG YEDYITEAMA
     LKDEYDFKLG NLMDHYGIKS EAEIISGCIL KMAKNFTKKS DADAIRLAVR SLRKEARSRF
     SEMSLDDNGH GHDASEAKAS AWYHVTYHPE FWGCYNEGYE RPHFISFPWC IYEKLLRIKQ
     RRKFVRKMQP ELFSLHNLRI