RDR1_YEAST
ID RDR1_YEAST Reviewed; 546 AA.
AC Q08904; D6W372;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Protein RDR1;
DE AltName: Full=Repressor of drug resistance protein 1;
GN Name=RDR1; OrderedLocusNames=YOR380W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=11353088; DOI=10.1093/nar/29.10.2181;
RA Akache B., Wu K., Turcotte B.;
RT "Phenotypic analysis of genes encoding yeast zinc cluster proteins.";
RL Nucleic Acids Res. 29:2181-2190(2001).
RN [4]
RP FUNCTION.
RX PubMed=11882665; DOI=10.1074/jbc.m201637200;
RA Hellauer K., Akache B., MacPherson S., Sirard E., Turcotte B.;
RT "Zinc cluster protein Rdr1p is a transcriptional repressor of the PDR5 gene
RT encoding a multidrug transporter.";
RL J. Biol. Chem. 277:17671-17676(2002).
CC -!- FUNCTION: Transcriptional repressor of multidrug resistance genes, such
CC as PDR5. Required for growth on non-fermentable carbon sources like
CC lactate or glycerol. {ECO:0000269|PubMed:11353088,
CC ECO:0000269|PubMed:11882665}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; Z75288; CAA99712.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA11138.1; -; Genomic_DNA.
DR PIR; S67292; S67292.
DR RefSeq; NP_015025.3; NM_001183800.3.
DR AlphaFoldDB; Q08904; -.
DR SMR; Q08904; -.
DR BioGRID; 34761; 107.
DR DIP; DIP-3904N; -.
DR IntAct; Q08904; 9.
DR MINT; Q08904; -.
DR STRING; 4932.YOR380W; -.
DR PaxDb; Q08904; -.
DR PRIDE; Q08904; -.
DR EnsemblFungi; YOR380W_mRNA; YOR380W; YOR380W.
DR GeneID; 854562; -.
DR KEGG; sce:YOR380W; -.
DR SGD; S000005907; RDR1.
DR VEuPathDB; FungiDB:YOR380W; -.
DR eggNOG; ENOG502QWPB; Eukaryota.
DR HOGENOM; CLU_019691_0_0_1; -.
DR InParanoid; Q08904; -.
DR OMA; FYRRLYQ; -.
DR BioCyc; YEAST:G3O-33843-MON; -.
DR PRO; PR:Q08904; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08904; protein.
DR GO; GO:0005634; C:nucleus; IC:SGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IMP:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; HDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009410; P:response to xenobiotic stimulus; IMP:SGD.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR040331; Rdr1.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR PANTHER; PTHR31779:SF3; PTHR31779:SF3; 1.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00906; Fungal_trans; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 4: Predicted;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..546
FT /note="Protein RDR1"
FT /id="PRO_0000114972"
FT DNA_BIND 20..46
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ SEQUENCE 546 AA; 61287 MW; 208D4572E24244F9 CRC64;
MASPGSTALP HKRQRVRKAC VPCRERKRKC NGKSPCEMCV AYGYVCHYID GRVPSASPQV
QQVGETSPDT ESRPFVLPGI HRNEQPQPIN TQNVTSQNIV DPTKSRYTIQ HSAVAFPRCL
GLELRSTNPP RLHSFAWHCG IRPEENPNSH VLLSDLVTKE EYYRISKVYF SVVHPIFDVV
NPEQLAKNVE KYWDGDVKTL EYGAVIAGVI ALGSFFMGSL GHPREMDIVQ YAKGILDDPT
FSRIPTVEQV SAWVLRTIYL RATSRPHVAW LASCVTIHLS EAIGLHHEID REDIAISNNV
PPKRTTVVSE HTRRLFWCAW SINTILSYDY GRSSVTLNRI TCKPVKETDG NFTAHLVALA
HLIPQDSVNA NAAQLLQALA AVHESPNAHP FLSLTKGDIC LSLYRRLRLL NHILDKNVVL
QIIDIGNTAL SAAYALVKLD QAWWNVLSTS FQYVCVLLAI DTPESLSHVA TAMKTLDNIT
QILGTRIAFE AQKTAKLLLE DSMKKKRQEI QQLEQATHQR SNLETTHLLD IDWDALLDPS
DTLNFM
