RDR5_ARATH
ID RDR5_ARATH Reviewed; 977 AA.
AC O82188; Q0WNQ6;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 08-FEB-2011, sequence version 2.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Probable RNA-dependent RNA polymerase 5;
DE Short=AtRDRP5;
DE EC=2.7.7.48;
DE AltName: Full=RNA-directed RNA polymerase 5;
GN Name=RDR5; Synonyms=RDRP5; OrderedLocusNames=At2g19930; ORFNames=F6F22.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 639-977.
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Probably involved in the RNA silencing pathway and required
CC for the generation of small interfering RNAs (siRNAs). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48;
CC -!- SIMILARITY: Belongs to the RdRP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC62123.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC005169; AAC62123.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06944.1; -; Genomic_DNA.
DR EMBL; AK229381; BAF01243.1; -; mRNA.
DR PIR; H84582; H84582.
DR RefSeq; NP_179583.3; NM_127551.4.
DR AlphaFoldDB; O82188; -.
DR SMR; O82188; -.
DR STRING; 3702.AT2G19930.1; -.
DR iPTMnet; O82188; -.
DR PaxDb; O82188; -.
DR PRIDE; O82188; -.
DR EnsemblPlants; AT2G19930.1; AT2G19930.1; AT2G19930.
DR GeneID; 816512; -.
DR Gramene; AT2G19930.1; AT2G19930.1; AT2G19930.
DR KEGG; ath:AT2G19930; -.
DR Araport; AT2G19930; -.
DR TAIR; locus:2052020; AT2G19930.
DR eggNOG; KOG0988; Eukaryota.
DR HOGENOM; CLU_008367_0_0_1; -.
DR InParanoid; O82188; -.
DR PRO; PR:O82188; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O82188; baseline and differential.
DR Genevisible; O82188; AT.
DR GO; GO:0031380; C:nuclear RNA-directed RNA polymerase complex; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IBA:GO_Central.
DR GO; GO:0030422; P:siRNA processing; IBA:GO_Central.
DR InterPro; IPR007855; RNA-dep_RNA_pol_euk-typ.
DR PANTHER; PTHR23079; PTHR23079; 1.
DR Pfam; PF05183; RdRP; 1.
PE 2: Evidence at transcript level;
KW Nucleotidyltransferase; Reference proteome; RNA-binding;
KW RNA-directed RNA polymerase; RNA-mediated gene silencing; Transferase.
FT CHAIN 1..977
FT /note="Probable RNA-dependent RNA polymerase 5"
FT /id="PRO_0000404676"
FT REGION 103..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 977 AA; 110889 MW; CFA6439E8996739A CRC64;
MNQASSRIRI ALSGRIETAL ENIYRKHNLT PINDETRQRL SSIPENLGFE LVRKVFSLQA
GLIYNLDSFI VSKVNQAVSF TGYPQPANSL SPSGRHVSRV LQEEMSVDSD APSPKSLKSE
DKGGSLHIPQ LVALGELEFK KVFLLLSYIP GQHVGQVITA DEIRLWKDLP MVEYEAAVWD
RLGRHYCPQK DRRMLQWDSG KTHYYQCNVA PNGSYTFKVL SALQGPLLEH TGTHLHKVLG
DDNVLTVKFA DVQKSSSTYS IDHYFTYKGI AKNGIMIGLR RYQFFVFKDG GKEEKKKDLS
TKKVKCYFIR TDSTAFYDMQ NPYILTGKSI YEARMHFMHV HRAPTLANYM ARFSLILSKT
KTLEVDMTGI TFDQIDDIHC HDQDGKDVLD KNKKPCIHSD GTGYISEDLA RMCPLNIFKG
KCLRSESIQE ACYQDPPLLI QFRMFYDGYA VKGTFLLNKK LCPRTVQVRP SMIKVSKDPS
LSNFSTFNAL EVVTTSNPPK RTKLSKNLVA LLSYGGIPNE FFLDILLNTL EESKSIFYNK
RAALNAALNY GEMDDQNAAQ MILVGIPLDE PHLKNYLSIL LKTEKNDLKA GKLPVTESYY
LMGTVDPTGA LKEDEVCVIL ESGQISGEVL VYRNPGLHFG DIHILKATYV KALEEYVGNS
KFAVFFPQKG PRSLGDEIAG GDFDGDMYFI SRNPELLENF KPSEPWVSLT PPSKSNSGRA
PSQLSPEELE EELFEMFLTA GFHASNVIGI AADSWLTIMD RFLILGDDRA EEKAEMKKKM
LELIDIYYDA LDAPKKGDKV YLPNKLKPDI FPHYMERDKK FQSTSILGLI FDFVKSQTTE
EPSPSSEISK LPCFEDEPVS EFHMQKCRLW YDNYRTEMTQ AMKTDKDESA NEVIQRYKQE
FYGAAGFEDS KKSLEELYPQ ALALYKIVYD YAIHAGVSKC RFVWKVAGPV LCRFYLNKKM
QEKCLVCAPS VLKELWG
