RDRP_AHSV9
ID RDRP_AHSV9 Reviewed; 1305 AA.
AC O70695;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=RNA-directed RNA polymerase;
DE EC=2.7.7.48;
DE AltName: Full=VP1;
GN Name=Segment-1;
OS African horse sickness virus 9 (AHSV-9).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX NCBI_TaxID=10897;
OH NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH NCBI_TaxID=9796; Equus caballus (Horse).
OH NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=9541625; DOI=10.1007/s007050050298;
RA Vreede F.T., Huismans H.;
RT "Sequence analysis of the RNA polymerase gene of African horse sickness
RT virus.";
RL Arch. Virol. 143:413-419(1998).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC -!- SIMILARITY: Belongs to the reoviridae RNA-directed RNA polymerase
CC family. {ECO:0000305}.
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DR EMBL; U94887; AAC40586.1; -; Genomic_RNA.
DR RefSeq; YP_052966.1; NC_006021.1.
DR SMR; O70695; -.
DR GeneID; 2943147; -.
DR KEGG; vg:2943147; -.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR007097; RNA-dir_pol_reovirus.
DR InterPro; IPR008723; RNA_pol_orbivir.
DR Pfam; PF05788; Orbi_VP1; 1.
DR PIRSF; PIRSF000821; RdRPol; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
DR PROSITE; PS50523; RDRP_DSRNA_REO; 1.
PE 3: Inferred from homology;
KW Nucleotide-binding; Nucleotidyltransferase; RNA-directed RNA polymerase;
KW Transferase; Viral RNA replication.
FT CHAIN 1..1305
FT /note="RNA-directed RNA polymerase"
FT /id="PRO_0000222661"
FT DOMAIN 563..814
FT /note="RdRp catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
SQ SEQUENCE 1305 AA; 150294 MW; 321E9E7F3CF6F11A CRC64;
MVITVQGADL VRRALNRLFK YGRIDGTKMY YEYYRYSSKM RETRRKKGTK YKTDDEFLER
ERDAGRLKLY DLQVIREASW EDLLYENVHT AELDIYVRSI LKLEDLEPEE EFLRNYAVYD
GVHPLKDFVE MRAKNEMQIF GDMPIKAWIS VLMEISRETK HKPLGLMVAS DFVGRFGSPF
EQNFRDLSQI NEYGYCYSSP LLFEMCVTES ILEFNMWYRM REERIQSLKF GLEVIDPFKL
IREFFEICLP HPKKINNTLR SPYSWFVKNW GIGCSRVKVL TSIGGEDRNS KEVFYTGYHE
TENLYSEIVL KSKFYRESLK QNMTKTEEAI TYSQKLGNHG RTMPIFLKML KAVYTTEFDP
TKISHVILAS LCLSIQTITG YGRAWVVNKS SDLEAQMKPS SDNYVQRVCD YTKNNFIKAY
EEARRGGEEI VMPEDMYTSI LRLAKNTSSG FSTSIDVFKR YGPNAKGGRG EKIQITSRIK
ALVIFTKGHE IFTPKNLALK YNTTEFFQTK GSRDVPIKST RIVYSINLSI LVPQLIVTLP
LNEYFARAGG STLPETQRMG GKIIVGDLEA TGSRVMDAAD TFRNSSDPLN LTIAIDYSEF
DTHLTPYNFR NGMLDGIREA MRRYQHLRYE GYTLDELIEF GYGEGRVMNT LWNGKRRVFK
VAFEDYVMLS DEDKVQGTFK PPIGVKPVKN IKICEELEKK ADGRDLILVS PTDGSDLALI
NTHLSGENST LIANSLHNLA IGTVIREEVK RIFGDDISFK SEQYVGDDTL FYTELRTRSV
ERFDSIVDTI FEVIKKSGHE ASMSKTLIAP FSVEKTQTHA KQGIYIPQDR MMLVSSERRK
DIEDVAGYLR SQVQTLTTKI SRGFSHELAQ IIFMMKSSII GHRKLKRTIK DGGYRDRKYD
DDKEDGFTLI MLRDPLIAFY PVEWNGFGAH PAAMNIIMTE DMFVDSVMRG ECRAWMEPLV
KLIDQSPPLW NETSADKRMI GTDSTMSFFS RMARPAVRTV LTNSEVGDAV RSLPLGDFSP
FNISKTMMHS ALLKEKNARS LLTPAYEMEY QKELQGWRPR QKKFLVTSNE MEITTNYMKM
FNVGKIPLHG LALKFFPDVN LSKEFFLQKS VLGNRESPRA RMSYVDRIDS ILRGDVVMRG
FITANTIINI LEKLGHTHSA SDLTTLFEIM NLSSSVAQRL SEYITTERVR FDAMKLSKRG
ICGDEFSMSL DVCTQTMVDR YIRAPTQFTK TELDAVNLYV AQHIMLDAAT GLTPSRYDIN
VSGDERVRFK QRVARFNTHL PKMRMVKRLI ETERLSARLV QNQFV