ID   RDRP_AHSV9              Reviewed;        1305 AA.
AC   O70695;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=RNA-directed RNA polymerase;
DE            EC=2.7.7.48;
DE   AltName: Full=VP1;
GN   Name=Segment-1;
OS   African horse sickness virus 9 (AHSV-9).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10897;
OH   NCBI_TaxID=9838; Camelus dromedarius (Dromedary) (Arabian camel).
OH   NCBI_TaxID=9615; Canis lupus familiaris (Dog) (Canis familiaris).
OH   NCBI_TaxID=9793; Equus asinus (Donkey) (Equus africanus asinus).
OH   NCBI_TaxID=9796; Equus caballus (Horse).
OH   NCBI_TaxID=9794; Equus hemionus (Onager) (Asian wild ass).
OH   NCBI_TaxID=89252; Equus quagga burchellii (Plains zebra) (Equus burchelli).
OH   NCBI_TaxID=9785; Loxodonta africana (African elephant).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=9541625; DOI=10.1007/s007050050298;
RA   Vreede F.T., Huismans H.;
RT   "Sequence analysis of the RNA polymerase gene of African horse sickness
RT   virus.";
RL   Arch. Virol. 143:413-419(1998).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC   -!- SIMILARITY: Belongs to the reoviridae RNA-directed RNA polymerase
CC       family. {ECO:0000305}.
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DR   EMBL; U94887; AAC40586.1; -; Genomic_RNA.
DR   RefSeq; YP_052966.1; NC_006021.1.
DR   SMR; O70695; -.
DR   GeneID; 2943147; -.
DR   KEGG; vg:2943147; -.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR007097; RNA-dir_pol_reovirus.
DR   InterPro; IPR008723; RNA_pol_orbivir.
DR   Pfam; PF05788; Orbi_VP1; 1.
DR   PIRSF; PIRSF000821; RdRPol; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50523; RDRP_DSRNA_REO; 1.
PE   3: Inferred from homology;
KW   Nucleotide-binding; Nucleotidyltransferase; RNA-directed RNA polymerase;
KW   Transferase; Viral RNA replication.
FT   CHAIN           1..1305
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000222661"
FT   DOMAIN          563..814
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
SQ   SEQUENCE   1305 AA;  150294 MW;  321E9E7F3CF6F11A CRC64;
     MVITVQGADL VRRALNRLFK YGRIDGTKMY YEYYRYSSKM RETRRKKGTK YKTDDEFLER
     ERDAGRLKLY DLQVIREASW EDLLYENVHT AELDIYVRSI LKLEDLEPEE EFLRNYAVYD
     GVHPLKDFVE MRAKNEMQIF GDMPIKAWIS VLMEISRETK HKPLGLMVAS DFVGRFGSPF
     EQNFRDLSQI NEYGYCYSSP LLFEMCVTES ILEFNMWYRM REERIQSLKF GLEVIDPFKL
     IREFFEICLP HPKKINNTLR SPYSWFVKNW GIGCSRVKVL TSIGGEDRNS KEVFYTGYHE
     TENLYSEIVL KSKFYRESLK QNMTKTEEAI TYSQKLGNHG RTMPIFLKML KAVYTTEFDP
     TKISHVILAS LCLSIQTITG YGRAWVVNKS SDLEAQMKPS SDNYVQRVCD YTKNNFIKAY
     EEARRGGEEI VMPEDMYTSI LRLAKNTSSG FSTSIDVFKR YGPNAKGGRG EKIQITSRIK
     ALVIFTKGHE IFTPKNLALK YNTTEFFQTK GSRDVPIKST RIVYSINLSI LVPQLIVTLP
     LNEYFARAGG STLPETQRMG GKIIVGDLEA TGSRVMDAAD TFRNSSDPLN LTIAIDYSEF
     DTHLTPYNFR NGMLDGIREA MRRYQHLRYE GYTLDELIEF GYGEGRVMNT LWNGKRRVFK
     VAFEDYVMLS DEDKVQGTFK PPIGVKPVKN IKICEELEKK ADGRDLILVS PTDGSDLALI
     NTHLSGENST LIANSLHNLA IGTVIREEVK RIFGDDISFK SEQYVGDDTL FYTELRTRSV
     ERFDSIVDTI FEVIKKSGHE ASMSKTLIAP FSVEKTQTHA KQGIYIPQDR MMLVSSERRK
     DIEDVAGYLR SQVQTLTTKI SRGFSHELAQ IIFMMKSSII GHRKLKRTIK DGGYRDRKYD
     DDKEDGFTLI MLRDPLIAFY PVEWNGFGAH PAAMNIIMTE DMFVDSVMRG ECRAWMEPLV
     KLIDQSPPLW NETSADKRMI GTDSTMSFFS RMARPAVRTV LTNSEVGDAV RSLPLGDFSP
     FNISKTMMHS ALLKEKNARS LLTPAYEMEY QKELQGWRPR QKKFLVTSNE MEITTNYMKM
     FNVGKIPLHG LALKFFPDVN LSKEFFLQKS VLGNRESPRA RMSYVDRIDS ILRGDVVMRG
     FITANTIINI LEKLGHTHSA SDLTTLFEIM NLSSSVAQRL SEYITTERVR FDAMKLSKRG
     ICGDEFSMSL DVCTQTMVDR YIRAPTQFTK TELDAVNLYV AQHIMLDAAT GLTPSRYDIN
     VSGDERVRFK QRVARFNTHL PKMRMVKRLI ETERLSARLV QNQFV