RDRP_AQRVC
ID RDRP_AQRVC Reviewed; 1274 AA.
AC Q8JU61;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 29-SEP-2021, entry version 58.
DE RecName: Full=RNA-directed RNA polymerase VP2;
DE EC=2.7.7.48;
GN Name=S2;
OS Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C).
OC Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC Reovirales; Reoviridae; Spinareovirinae; Aquareovirus.
OX NCBI_TaxID=185783;
OH NCBI_TaxID=28800; Notemigonus crysoleucas (Golden shiner) (Cyprinus crysoleucas).
OH NCBI_TaxID=90988; Pimephales promelas (Fathead minnow).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=12124458; DOI=10.1099/0022-1317-83-8-1941;
RA Attoui H., Fang Q., Mohd Jaafar F., Cantaloube J.F., Biagini P.,
RA de Micco P., de Lamballerie X.;
RT "Common evolutionary origin of aquareoviruses and orthoreoviruses revealed
RT by genome characterization of Golden shiner reovirus, Grass carp reovirus,
RT Striped bass reovirus and golden ide reovirus (genus Aquareovirus, family
RT Reoviridae).";
RL J. Gen. Virol. 83:1941-1951(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=16171838; DOI=10.1016/j.virol.2005.08.028;
RA Attoui H., Mohd Jaafar F., Belhouchet M., Biagini P., Cantaloube J.F.,
RA de Micco P., de Lamballerie X.;
RT "Expansion of family Reoviridae to include nine-segmented dsRNA viruses:
RT isolation and characterization of a new virus designated Aedes
RT pseudoscutellaris reovirus assigned to a proposed genus (Dinovernavirus).";
RL Virology 343:212-223(2005).
CC -!- FUNCTION: RNA-directed RNA polymerase that is involved in transcription
CC and genome replication. Following infection, it catalyzes the synthesis
CC of fully conservative plus strands. After core assembly, which consists
CC in recruitment of one capped plus-strand for each genomic segments and
CC polymerase complexes, the polymerase switches mode and catalyzes the
CC synthesis of complementary minus-strands (By similarity).
CC {ECO:0000255|PROSITE-ProRule:PRU00539}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the reoviridae RNA-directed RNA polymerase
CC family. {ECO:0000305}.
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DR EMBL; AF403399; AAM92745.1; -; Genomic_RNA.
DR RefSeq; NP_938061.1; NC_005167.1.
DR SMR; Q8JU61; -.
DR GeneID; 2648330; -.
DR KEGG; vg:2648330; -.
DR Proteomes; UP000006713; Genome.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR012915; RdRP_5.
DR InterPro; IPR007097; RNA-dir_pol_reovirus.
DR Pfam; PF07925; RdRP_5; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
DR PROSITE; PS50523; RDRP_DSRNA_REO; 1.
PE 3: Inferred from homology;
KW Hydrolase; Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW RNA-directed RNA polymerase; Transferase; Viral RNA replication; Virion.
FT CHAIN 1..1274
FT /note="RNA-directed RNA polymerase VP2"
FT /id="PRO_0000404172"
FT DOMAIN 561..798
FT /note="RdRp catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
SQ SEQUENCE 1274 AA; 141581 MW; 34C11609EF1B3D72 CRC64;
MEELFNALPQ PLQQLSLALA GEIPLTDHIF EQAASTWHVQ PRSLTYKLLD HIPFSTPVVV
PPSIYHSLDW SKCFAVNQDR VERVPTIDDP DDVYVPNSDI GPLLTSLHTI PDYGFLHPAI
ENDATTLRAE RARCASTFYK IASSQARQVK LDPIRMLGFL LLVQARPRVP SGLVTDQPTR
RDPTQSPALH AIWQVMQYYK VAGVYYAPAL VVPSGAIWWI PPPGKRNVVS VQYLLTDLIN
LAILAHMTDM SPTLELTGVL MYLRAASSHS HAYTLLQMKS VFPALSLRSM YRNKGFGGKA
PAIEWTEPRS KYKFRWTGVT QLHDGLRPRS PSMDVPTLEV LTKYELVDIG HIIIRERNAH
PRHNHDSVRF VRDVMALTSG MYLVRQPTMS VLREYSQVPD IKDPIPPSAW TGPIGNVRYL
LPSVQGPARH LYDTWRAAAR QIAQDPQWHD PLNQAIMRAQ YVTARGGSSA SLKFALKVTG
IVLPEYDDSK VKKSSKIYQA AQIARIAFML LIAAIHAEVT MGIRNQVQRR ARSIMPLNVI
QQAISAPHTL VANYINKHMN LSTTSGSVVT DKVIPLILYA STPPNTVVNV DIKACDASIT
YNYFLSVICG AMHEGFEVGN ADAAFMGVPS TIVSDRRSSV APYSRPISGL QTMVQHLADL
YAAGFRYSVS DAFSSGNKFS FPTSTFPSGS TATSTEHTAN NSTMMEYFLN VHAPSHVKSA
SLKRILTDMT IQRNYVCQGD DGILLLPHEA ASKISADDMN ELLTCLRDYG QLFGWNYDID
WSDTAEYLKL YALMGCRIPN TSRHPPVGKE YAAPQTDEIW PSLIDIVIGH HLNGVTDVLN
WREWLRFSWA FACYSSRGGY TNPKGQSFSA QYPWWTFVYL GIPPILLPGQ TPFIHSCYMP
PGDQGMFSIL NGWRDWLISH ASTTLPPLRH NHPVWGLSDV PSLLSQFGVY AGYHAAQHYR
RPKPAPETAS SDSINQITSD LTEYLFYDSA LKARVMKGRY NWERLSSSLS LNVGSRVPSL
FDVPGKWVAA GRDAEKPPPS SVEDMFTSLN RCIRRPTHSF SRLLELYLRV HVTLGESIPL
AIDPDVPQVA GADPANDDHW FKYTCLGDIP SATRNYFGES LFVGRVVSGL DVEAVDATLL
RLKILGAPPE AFIAVLNGIG MSDSEAHQIA GRISLANAQL VQIARVVHLS IPSSWMTLNT
GPYIHHHAYD FKPGITQPSA KSRDKSIWMS PILKLLCTSY AMTVAGPVRT SIVTEIDGSA
AALSGNLRVW MRDV