ID   RDRP_BAVJK              Reviewed;        1214 AA.
AC   Q9INJ1;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   29-SEP-2021, entry version 60.
DE   RecName: Full=RNA-directed RNA polymerase VP1;
DE            EC=2.7.7.48;
DE   AltName: Full=Virion protein 1;
DE            Short=VP1;
GN   Name=Segment-1; Synonyms=S1;
OS   Banna virus (strain Indonesia/JKT-6423/1980) (BAV).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Seadornavirus.
OX   NCBI_TaxID=649604;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=182211; Culex annulus.
OH   NCBI_TaxID=7178; Culex tritaeniorhynchus (Mosquito).
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=10811934; DOI=10.1099/0022-1317-81-6-1507;
RA   Attoui H., Billoir F., Biagini P., de Micco P., de Lamballerie X.;
RT   "Complete sequence determination and genetic analysis of Banna virus and
RT   Kadipiro virus: proposal for assignment to a new genus (Seadornavirus)
RT   within the family Reoviridae.";
RL   J. Gen. Virol. 81:1507-1515(2000).
CC   -!- FUNCTION: RNA-directed RNA polymerase that is involved in transcription
CC       and genome replication. Following infection, it catalyzes the synthesis
CC       of fully conservative plus strands. After core assembly, which consists
CC       in recruitment of one capped plus-strand for each genomic segments and
CC       polymerase complexes, the polymerase switches mode and catalyzes the
CC       synthesis of complementary minus-strands (By similarity).
CC       {ECO:0000255|PROSITE-ProRule:PRU00539}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC   -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the reoviridae RNA-directed RNA polymerase
CC       family. {ECO:0000305}.
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DR   EMBL; AF133430; AAF78849.1; -; Genomic_RNA.
DR   RefSeq; NP_694469.1; NC_004211.1.
DR   GeneID; 995347; -.
DR   KEGG; vg:995347; -.
DR   Proteomes; UP000000832; Genome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   InterPro; IPR007097; RNA-dir_pol_reovirus.
DR   InterPro; IPR026381; Seadorna_RNAP.
DR   TIGRFAMs; TIGR04234; seadorna_RNAP; 1.
DR   PROSITE; PS50523; RDRP_DSRNA_REO; 1.
DR   PROSITE; PS00052; RIBOSOMAL_S7; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW   RNA-directed RNA polymerase; Transferase; Viral RNA replication; Virion.
FT   CHAIN           1..1214
FT                   /note="RNA-directed RNA polymerase VP1"
FT                   /id="PRO_0000404236"
FT   DOMAIN          610..805
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
SQ   SEQUENCE   1214 AA;  137462 MW;  5DC7DBCF561E7A64 CRC64;
     MDIQEQFEGY LREEVDLLNK FEDSHFKQLE VFYTNSQADH VINKDKAQFS DLPFHTTLYK
     EVNGKRVKLG TLLNWTKAER LDTIRHESMI KDERLRRLID FDYSWIDYAV VLQRYLDEGN
     VIAPADILKF DSDFINNIKH PTEKNNFLDI KVIKECETYI LMKDDNGIRD PDILRAWELD
     SIPDVIELDV DGEVKKFNLR KEMIKRIQDE APVYFFASVS LCSRNLDPNI SEVKLWLEYF
     IGSEDFFGFN GPNVVVSKSL LAAKRFEVVV NHLRKVAAFE LDDESKEVMT EWLKYIMIDP
     VYRSYKNRGA FGNLNQHVFA RTKSEGLSWS LIDIGTTNFE LKPTKKLAGS YVKKFNLVDD
     VLVEESLKDL RNEGLYKMAD ITRRMIDADI TPENVKKGKL NRLALSYCGY TGSHSATAMV
     KQFNGTKDLD PNCDPMFVDI VKDNMKVYMQ EGLQKYPHGS RKINRLDILF KGGTSSASST
     NEHATVNGRF RYRSELYRER DVNSSTVFKT ATAGQYRVVK KISAKLKSKN ANIITHPMNF
     INSKVSDLDV VVNAGSRLVR GTRAKRIITP NYGTIYAASL MTVLPAVRLL SSRASNMGAL
     STQGSLVDRA PHDVMAPQLA VTSSDDVSKV CVAKDFGQFD TSQWGQISKA HADGVRSMKV
     HYSMGHDALV DLDLNDASFA DLLEVTAMSF EKPLKYKMNG LVCESAGVKS GELTTQTRNT
     TTNISHSTVA LDDYNNRAYR LNLPKLELVT DNKVGDDSVE VLRVVDGSPL TPEIAKLYVS
     CMQDHADRNH LEISAKRTIV GNNVAEHIKI WVFKGYLALD VFLDSVTSEK NSFSNLNYLE
     QVNILYDMAM TLMIRYCSVQ ACMTQFCNDM KLLNGIRAGN YTFIPTPKII CAYGTPEICL
     RAPEIRSFGR YLPIDKDEYS VLNDLVASLS TNKPKMEFVS QMIEQNGNKV HSLWLDHFKR
     KNDVNPNGGG IHISEGLKRL MPEYCEKHLN ELVYKTLDDK VIRDYTSDII ISNICKGKLS
     KAPKLAFYAN FYLSLTNTNG VDSPYLTADE GVKNVHRVIG LSYRNTLSTS PTSNVDRILR
     NNPGSAPAYL TGNDILGVLS DYPYQNWRTV VELLDITEPS ATAIIEVATN QMHAYLADKD
     LNTANLFDNT SRTYDISDRT YPKFVNITSS LSNSNRRGFQ IEAMKHVIYM ARRGVAVLAN
     THPTKIGNTV YYDY