RDRP_BBV
ID RDRP_BBV Reviewed; 998 AA.
AC Q96631;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2002, sequence version 2.
DT 29-SEP-2021, entry version 65.
DE RecName: Full=RNA-directed RNA polymerase;
DE Short=RdRp;
DE EC=2.7.7.48;
DE AltName: Full=RNA replicase;
DE Short=Protein A;
OS Black beetle virus (BBV).
OC Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Magsaviricetes;
OC Nodamuvirales; Nodaviridae; Alphanodavirus.
OX NCBI_TaxID=12285;
OH NCBI_TaxID=295550; Heteronychus arator (African black beetle).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=3839022; DOI=10.1016/0022-2836(85)90337-7;
RA Dasmahapatra B., Dasgupta R., Ghosh A., Kaesberg P.;
RT "Structure of the black beetle virus genome and its functional
RT implications.";
RL J. Mol. Biol. 182:183-189(1985).
RN [2]
RP PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE.
RX PubMed=6495657; DOI=10.1016/0042-6822(84)90342-8;
RA Guarino L.A., Ghosh A., Dasmahapatra B., Dasgupta R., Kaesberg P.;
RT "Sequence of the black beetle virus subgenomic RNA and its location in the
RT viral genome.";
RL Virology 139:199-203(1984).
CC -!- FUNCTION: RNA-dependent RNA polymerase which replicates the viral
CC genome composed of 2 RNA segments, RNA1 AND RNA2. {ECO:0000305}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48;
CC -!- SIMILARITY: Belongs to the nodaviridae RNA polymerase family.
CC {ECO:0000305}.
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DR EMBL; X02396; CAA26238.1; -; Genomic_RNA.
DR PIR; S78471; QQBBB1.
DR RefSeq; YP_053043.1; NC_001411.2.
DR GeneID; 956649; -.
DR KEGG; vg:956649; -.
DR Proteomes; UP000203003; Genome.
DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR043647; Noda_Vmethyltr_dom.
DR InterPro; IPR020237; Viral_RNA-dir_pol_C.
DR Pfam; PF19222; Noda_Vmethyltr; 1.
DR Pfam; PF17501; Viral_RdRp_C; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase; RNA-directed RNA polymerase; Transferase.
FT CHAIN 1..998
FT /note="RNA-directed RNA polymerase"
FT /id="PRO_0000222444"
FT REGION 901..998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 901..925
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 998 AA; 112197 MW; A57DA34AFE0A296B CRC64;
MTLKVILGEH QITRTELPVG IATVSGCGAV VYCISKFWGY GAIAPYPQSG GNRVTRALQR
AVIDKTKTPI ETRFYPLDSL RTVTPKRAVD NGHAVSGAVR DAARRLIDES ITAVGGSKFE
VNPNPNSSTG LRNHFHFAVG DLAQDFRNDT PADDAFIVGV DVDYYVTEPD VLLEHMRPVV
LHTFNPKKVS GFDADSPFTI KNNLVEYKVS GGAAWVHPVW DWCEAGEFIA SRVRTSWKEW
FLQLPLRMIG LEKVGYHKIH HCRPWTDCPD RALVYTIPQY VIWRFNWIDT ELHVRKLKRI
EYQDETKPGW NRLEYVTDRN ELLVSIGREG EHAQITIEKE KLDMLSGLSA TQSVNVRLIG
MGHKDPQYTS MIVQYYTGKK VVSPISPTVY KPTMPRVHWP VTSDADVPEV SARQYTLPIV
SDCMMMPMIK RWETMSESIE RRVTFVANDK KPSDRIAKIA ETFVKLMNGP FKDLDPLSIE
ETIERLNKPS QQLQLRAVFE MIGVEPRQLI ESFNKNEPGM KSSRIISGFP DILFILKVSR
YTLAYSDIVL HAEHNEHWYY PGRNPTEIAD GVCEFVSECD AEVIETDFSN LDGRVSSWMQ
RNIAQKAMVQ AFRPEYRDEI ISFMDTIINC SAKAKRFGFR YEPGVGVKSG SSTTTPHNTQ
YNGCVEFTAL TFEHPDAEPE DLFRLIGPKC GDDGLSRAII QKSINRAAKC FGLELKVERY
NPEIGLCFLS RVFVDPLATT TTIQDPLRTL RKLHLTTRDP TIPLADAACD RVEGHLCTDA
LTPLISDYCK MVLRLYGPTA STEQVRNQRR SRNKEKPYWL TCDGSWPQHP QDAHLMKQVL
IKRTAIDEDQ VDALIGRFAA MKDVWEKITH DSEESAAACT FDEDGVAPNS VDESLPMLND
AKQTRANPGT SRPHSNGGGS SHGNELPRRT EQRAQGPRQP ARLPKQGKTN GKSDGNITAG
ETQRGGIPRG KGPRGGKTNT RRTPPKAGAQ PQPSNNRK