ID   RDRP_BBV                Reviewed;         998 AA.
AC   Q96631;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2002, sequence version 2.
DT   29-SEP-2021, entry version 65.
DE   RecName: Full=RNA-directed RNA polymerase;
DE            Short=RdRp;
DE            EC=2.7.7.48;
DE   AltName: Full=RNA replicase;
DE            Short=Protein A;
OS   Black beetle virus (BBV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Magsaviricetes;
OC   Nodamuvirales; Nodaviridae; Alphanodavirus.
OX   NCBI_TaxID=12285;
OH   NCBI_TaxID=295550; Heteronychus arator (African black beetle).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=3839022; DOI=10.1016/0022-2836(85)90337-7;
RA   Dasmahapatra B., Dasgupta R., Ghosh A., Kaesberg P.;
RT   "Structure of the black beetle virus genome and its functional
RT   implications.";
RL   J. Mol. Biol. 182:183-189(1985).
RN   [2]
RP   PRELIMINARY PARTIAL NUCLEOTIDE SEQUENCE.
RX   PubMed=6495657; DOI=10.1016/0042-6822(84)90342-8;
RA   Guarino L.A., Ghosh A., Dasmahapatra B., Dasgupta R., Kaesberg P.;
RT   "Sequence of the black beetle virus subgenomic RNA and its location in the
RT   viral genome.";
RL   Virology 139:199-203(1984).
CC   -!- FUNCTION: RNA-dependent RNA polymerase which replicates the viral
CC       genome composed of 2 RNA segments, RNA1 AND RNA2. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48;
CC   -!- SIMILARITY: Belongs to the nodaviridae RNA polymerase family.
CC       {ECO:0000305}.
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DR   EMBL; X02396; CAA26238.1; -; Genomic_RNA.
DR   PIR; S78471; QQBBB1.
DR   RefSeq; YP_053043.1; NC_001411.2.
DR   GeneID; 956649; -.
DR   KEGG; vg:956649; -.
DR   Proteomes; UP000203003; Genome.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043647; Noda_Vmethyltr_dom.
DR   InterPro; IPR020237; Viral_RNA-dir_pol_C.
DR   Pfam; PF19222; Noda_Vmethyltr; 1.
DR   Pfam; PF17501; Viral_RdRp_C; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; RNA-directed RNA polymerase; Transferase.
FT   CHAIN           1..998
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000222444"
FT   REGION          901..998
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        901..925
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        983..998
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   998 AA;  112197 MW;  A57DA34AFE0A296B CRC64;
     MTLKVILGEH QITRTELPVG IATVSGCGAV VYCISKFWGY GAIAPYPQSG GNRVTRALQR
     AVIDKTKTPI ETRFYPLDSL RTVTPKRAVD NGHAVSGAVR DAARRLIDES ITAVGGSKFE
     VNPNPNSSTG LRNHFHFAVG DLAQDFRNDT PADDAFIVGV DVDYYVTEPD VLLEHMRPVV
     LHTFNPKKVS GFDADSPFTI KNNLVEYKVS GGAAWVHPVW DWCEAGEFIA SRVRTSWKEW
     FLQLPLRMIG LEKVGYHKIH HCRPWTDCPD RALVYTIPQY VIWRFNWIDT ELHVRKLKRI
     EYQDETKPGW NRLEYVTDRN ELLVSIGREG EHAQITIEKE KLDMLSGLSA TQSVNVRLIG
     MGHKDPQYTS MIVQYYTGKK VVSPISPTVY KPTMPRVHWP VTSDADVPEV SARQYTLPIV
     SDCMMMPMIK RWETMSESIE RRVTFVANDK KPSDRIAKIA ETFVKLMNGP FKDLDPLSIE
     ETIERLNKPS QQLQLRAVFE MIGVEPRQLI ESFNKNEPGM KSSRIISGFP DILFILKVSR
     YTLAYSDIVL HAEHNEHWYY PGRNPTEIAD GVCEFVSECD AEVIETDFSN LDGRVSSWMQ
     RNIAQKAMVQ AFRPEYRDEI ISFMDTIINC SAKAKRFGFR YEPGVGVKSG SSTTTPHNTQ
     YNGCVEFTAL TFEHPDAEPE DLFRLIGPKC GDDGLSRAII QKSINRAAKC FGLELKVERY
     NPEIGLCFLS RVFVDPLATT TTIQDPLRTL RKLHLTTRDP TIPLADAACD RVEGHLCTDA
     LTPLISDYCK MVLRLYGPTA STEQVRNQRR SRNKEKPYWL TCDGSWPQHP QDAHLMKQVL
     IKRTAIDEDQ VDALIGRFAA MKDVWEKITH DSEESAAACT FDEDGVAPNS VDESLPMLND
     AKQTRANPGT SRPHSNGGGS SHGNELPRRT EQRAQGPRQP ARLPKQGKTN GKSDGNITAG
     ETQRGGIPRG KGPRGGKTNT RRTPPKAGAQ PQPSNNRK