ID   RDRP_BOOLV              Reviewed;         998 AA.
AC   Q992J0;
DT   16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   29-SEP-2021, entry version 52.
DE   RecName: Full=RNA-directed RNA polymerase;
DE            Short=RdRp;
DE            EC=2.7.7.48;
DE   AltName: Full=RNA replicase;
DE            Short=Protein A;
OS   Boolarra virus (BoV).
OC   Viruses; Riboviria; Orthornavirae; Kitrinoviricota; Magsaviricetes;
OC   Nodamuvirales; Nodaviridae; Alphanodavirus.
OX   NCBI_TaxID=12286;
OH   NCBI_TaxID=41021; Hepialidae (ghost moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=11457991; DOI=10.1099/0022-1317-82-8-1855;
RA   Johnson K.N., Johnson K.L., Dasgupta R., Gratsch T., Ball L.A.;
RT   "Comparisons among the larger genome segments of six nodaviruses and their
RT   encoded RNA replicases.";
RL   J. Gen. Virol. 82:1855-1866(2001).
CC   -!- FUNCTION: RNA-dependent RNA polymerase which replicates the viral
CC       genome composed of 2 RNA segments, RNA1 AND RNA2. {ECO:0000305}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48;
CC   -!- SIMILARITY: Belongs to the nodaviridae RNA polymerase family.
CC       {ECO:0000305}.
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DR   EMBL; AF329080; AAK15751.1; -; Genomic_RNA.
DR   RefSeq; NP_689439.1; NC_004142.1.
DR   GeneID; 956656; -.
DR   KEGG; vg:956656; -.
DR   Proteomes; UP000204043; Genome.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR043647; Noda_Vmethyltr_dom.
DR   InterPro; IPR020237; Viral_RNA-dir_pol_C.
DR   Pfam; PF19222; Noda_Vmethyltr; 1.
DR   Pfam; PF17501; Viral_RdRp_C; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
PE   3: Inferred from homology;
KW   Nucleotidyltransferase; RNA-directed RNA polymerase; Transferase.
FT   CHAIN           1..998
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000222445"
FT   REGION          901..998
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        901..936
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        944..958
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   998 AA;  111204 MW;  7FAFFE4FC7329253 CRC64;
     MTIKIILGEH QITRTELLGG IVIVSGCGAV AYCISKFWGY GAIAPYPQSG GNRVTRALQR
     AVIDKTKTPI KTHFYPLDSL RTVTPRRASD NGHAVSGAVR DAARRLINES IETVGGSKFE
     LNPNPNSTMG PRNHFHFAVG DLAQNFRDDQ PAADAFIVGV DVDYYITEPD VLLEHMRPLV
     LHTFNPKKVS GFDADSPFTI NNNLVEYKVS GGAAWVHPVW DWCEAGEFIA SRVRSSWFEW
     LLQLPLRCLG LERVGYHKIH HCRPWTDCPD RALVYTIPQH TVWRFTWIDT EIHTRKLKRI
     TYQDNTKPGW NRLEHVSDNN QLLVSIGREG EHMQITIEKD KLEMLSGLGA TQSVNARLIG
     MGHKDPLYTS MIVQYYTGKK VVLSVAPTVY RPTMPRVHWP VTSDADVPEV SARQYTKPII
     SDCMMMPMIK RWETMSESIE RRVTFVANNK KPSDAVAKIA AEFVSLMNGP FIDLEPLTIE
     ETVERLNKPS QQLQLRAVFE IMGVEPRQVI ESFNKNEPGM KSSRIISAFP DILFIVKVSR
     YTLAYSDAVL HAEHNQHWYY PGRTPVGITD GVCEFVSDCD GQVIETDFSN LDGRVSGWMQ
     RNIAQKAMVQ AFRAEYRDEI ISFMDTIINC PAKAKRFGFR YEPGMGVKSG SPTTTPHNTQ
     YNACVEYTAL KFEYPDANPE DLFSLLGPKC GDDGLARATI QKTINRAAKC YGLELKVEKY
     NPEVGLCFLS RVFVDPLNTP TTIQDPLRTL RKLHITTRDP TIPIADAACD RVEGYLCTDA
     HTPLISEYCR MVQRLYGPKT STRDVREARR SRNKEKPYWL TCDGSWPQHP QDALLMKQIV
     VSRTGIDEDT VDKLIGRFAA MKDVWEPITL ESEESKAAQT IDEEGVAPGS VDESLLKLND
     AKQTRSNSGT SGPHTKGGGS GTGNELPRST KQRAKGPRQS AGLPKQGKAN SKPNGNVAAG
     QAQHGGIPRG KTPSGGKTNA RRAPPKAGAQ PGAPTNPK