RDRP_BPGA
ID RDRP_BPGA Reviewed; 532 AA.
AC P07393;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=RNA-directed RNA polymerase beta chain;
DE EC=2.7.7.48 {ECO:0000250|UniProtKB:P00585};
DE AltName: Full=RNA replicase beta chain;
OS Enterobacteria phage GA (Bacteriophage GA).
OC Viruses; Riboviria; Orthornavirae; Lenarviricota; Leviviricetes;
OC Norzivirales; Fiersviridae; Emesvirus; Emesvirus japonicum.
OX NCBI_TaxID=12018;
OH NCBI_TaxID=562; Escherichia coli.
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3711059; DOI=10.1093/oxfordjournals.jbchem.a135580;
RA Inokuchi Y., Takahashi R., Hirose T., Inayama S., Jacobson A.B.,
RA Hirashima A.;
RT "The complete nucleotide sequence of the group II RNA coliphage GA.";
RL J. Biochem. 99:1169-1180(1986).
CC -!- FUNCTION: This is the catalytic subunit of the viral RNA-dependent RNA
CC polymerase complex. This complex is involved in viral RNA replication
CC that produces (+)-stranded genomes via a complementary, (-)-stranded
CC intermediate. {ECO:0000250|UniProtKB:P00585}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC EC=2.7.7.48; Evidence={ECO:0000250|UniProtKB:P00585,
CC ECO:0000255|PROSITE-ProRule:PRU00539};
CC -!- SUBUNIT: Part of the viral RNA-dependent RNA polymerase complex, the
CC other subunits are probably the host ribosomal protein S1, EF-Tu and
CC EF-Ts. {ECO:0000250|UniProtKB:P00585}.
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DR EMBL; X03869; CAA27499.1; -; mRNA.
DR PIR; JS0008; RRBPBG.
DR SMR; P07393; -.
DR PRIDE; P07393; -.
DR Proteomes; UP000002126; Genome.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR007096; RNA-dir_Rpol_phage_catalytic.
DR InterPro; IPR005093; RNArep_beta.
DR Pfam; PF03431; RNA_replicase_B; 1.
DR SUPFAM; SSF56672; SSF56672; 1.
DR PROSITE; PS50522; RDRP_PHAGE; 1.
PE 2: Evidence at transcript level;
KW Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW RNA-directed RNA polymerase; Transferase; Viral RNA replication.
FT CHAIN 1..532
FT /note="RNA-directed RNA polymerase beta chain"
FT /id="PRO_0000164852"
FT DOMAIN 245..375
FT /note="RdRp catalytic"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
SQ SEQUENCE 532 AA; 59929 MW; EF416B83D504CEE3 CRC64;
MFRFREIEKT LCMDRTRDCA VRFHVYLQSL DLGSSDPLSP DFDGLAYLRD ECLTKHPSLG
DSNSDARRKE LAYAKLMDSD QRCKIQNSNG YDYSHIESGV LSGILKTAQA LVANLLTGFE
SHFLNDCSFS NGASQGFKLR DAAPFKKIAG QATVTAPAYD IAVAAVKTCA PWYAYMQETY
GDETKWFRRV YGNGLFSVPK NNKIDRAACK EPDMNMYLQK GAGSFIRKRL RSVGIDLNDQ
TRNQELARLG SIDGSLATID LSSASDSISD RLVWDLLPPH VYSYLARIRT SFTMIDGRLH
KWGLFSTMGN GFTFELESMI FWALSKSIML SMGVTGSLGI YGDDIIVPVE CRPTLLKVLS
AVNFLPNEEK TFTTGYFRES CGAHFFKDAD MKPFYCKRPM ETLPDVMLLC NRIRGWQTVG
GMSDPRLFPI WKEFADMIPP KFKGGCNLDR DTYLVSPDKP GVSLVRIAKV RSGFNHAFPY
GHENGRYVHW LHMGSGEVLE TISSARYRCK PNSEWRTQIP LFPQELEACV LS