ID   RDRP_BTV10              Reviewed;        1302 AA.
AC   P13840;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   29-SEP-2021, entry version 79.
DE   RecName: Full=RNA-directed RNA polymerase;
DE            EC=2.7.7.48;
DE   AltName: Full=VP1;
GN   Name=Segment-1;
OS   Bluetongue virus 10 (isolate USA) (BTV 10).
OC   Viruses; Riboviria; Orthornavirae; Duplornaviricota; Resentoviricetes;
OC   Reovirales; Reoviridae; Sedoreovirinae; Orbivirus.
OX   NCBI_TaxID=10900;
OH   NCBI_TaxID=9891; Antilocapra americana (Pronghorn).
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
OH   NCBI_TaxID=9925; Capra hircus (Goat).
OH   NCBI_TaxID=46212; Culicoides variipennis (Biting midge).
OH   NCBI_TaxID=9940; Ovis aries (Sheep).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=2850542; DOI=10.1093/nar/16.24.11759;
RA   Roy P., Fukusho A., Ritter G.D., Lyon D.;
RT   "Evidence for genetic relationship between RNA and DNA viruses from the
RT   sequence homology of a putative polymerase gene of bluetongue virus with
RT   that of vaccinia virus: conservation of RNA polymerase genes from diverse
RT   species.";
RL   Nucleic Acids Res. 16:11759-11767(1988).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate +
CC         RNA(n+1); Xref=Rhea:RHEA:21248, Rhea:RHEA-COMP:14527, Rhea:RHEA-
CC         COMP:17342, ChEBI:CHEBI:33019, ChEBI:CHEBI:61557, ChEBI:CHEBI:140395;
CC         EC=2.7.7.48; Evidence={ECO:0000255|PROSITE-ProRule:PRU00539};
CC   -!- SIMILARITY: Belongs to the reoviridae RNA-directed RNA polymerase
CC       family. {ECO:0000305}.
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DR   EMBL; X12819; CAA31306.1; -; Genomic_RNA.
DR   PIR; A34296; RRXRBT.
DR   RefSeq; YP_052968.1; NC_006023.1.
DR   SMR; P13840; -.
DR   GeneID; 2943156; -.
DR   KEGG; vg:2943156; -.
DR   Proteomes; UP000007662; Genome.
DR   GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0003968; F:RNA-directed 5'-3' RNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0019079; P:viral genome replication; IEA:InterPro.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR007097; RNA-dir_pol_reovirus.
DR   InterPro; IPR008723; RNA_pol_orbivir.
DR   Pfam; PF05788; Orbi_VP1; 1.
DR   PIRSF; PIRSF000821; RdRPol; 1.
DR   SUPFAM; SSF56672; SSF56672; 1.
DR   PROSITE; PS50523; RDRP_DSRNA_REO; 1.
PE   3: Inferred from homology;
KW   Nucleotide-binding; Nucleotidyltransferase; Reference proteome;
KW   RNA-directed RNA polymerase; Transferase; Viral RNA replication.
FT   CHAIN           1..1302
FT                   /note="RNA-directed RNA polymerase"
FT                   /id="PRO_0000222660"
FT   DOMAIN          562..823
FT                   /note="RdRp catalytic"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00539"
SQ   SEQUENCE   1302 AA;  149587 MW;  0C063AE396F0C33D CRC64;
     MVAITVQGAQ LIKRVVERFY PGIAFDINEG ACYIYKFSDH IRRIRMKHGT KYRRQAEEIM
     RSISLRKERL YGIPVLDEVE WKYVFDGQTF QSYAFEVYVN SILPWSELDP EEEFLRNYRV
     SRETTEVEKF IEFRAKNEMQ IYGDIPIKVW CCFINELSIE LNPIPLGMQV MADFVNRFNS
     PFHQGNRDLS NLEDFQVAYT TPLLFEMCCM ESILEFNIKM RMREEDISAL EFGDIKIDPV
     GLLREFFILC LPHPKKINNV LRAPYSWFVK MWGVGADPIV VLQSTAGDDR NSKDVFYDKF
     RTEPNRYKAL FRSSFYNESR RMNEEKILEA VKYSQNLGSH DRRLPLFEKM LKMVYTTPFY
     PHKSSNMILA SFLLSIQTIT GYGRAWVKNV STEFDKQLKP NPSNLVRDVS DLTREFFKQA
     YVEAKERREE MVKPEDLYTS MLRLARNTSS GFSTEIYVKK RFGPRLRDKD LVKINSRIKA
     LVIFTKGHTV FTDEELHKKY NSVELYQTKG SRDVPIKATR TIYSINLSVL VPQLIVTLPL
     NEYFSRVGGI TRPDYKKIGG KVIVGDLEAT GSRVMDAADC FRNSADRDIF TIAIDYSEYD
     THLTRHNFRT GMLQGIREAM APYRALRYEG YTLEQIIDFG YGEGRVANTL WNGKRRLFKT
     TFDAYIRLDE SERDKGSFKV PKGVLPVSSV DVANRIAVDK GFDTLIAATD GSDLALIDTH
     LSGENSTLIA NSMHNMAIGT LIQRAVGREQ PGILTFLSEQ YVGDDTLFYT KLHTTDITVF
     DKVAASIFDT VAKCGHEASP SKTMMTPYSV EKTQTHAKQG CYVPQDRMMI ISSERRKDIE
     DVQGYVRSQV QTMITKVSRG FCHDLAQLIL MLKTTFIGAW KMKRTIKENA MYRDRKFDSN
     DEDGFTLIQI RNPLALYVPI GWNGYGAHPA ALNIVMTEEM YVDSIMISKL DEIMAPIRRI
     VHDIPPCWNE TQGDKRGLIS ATKLSFFSKM ARPAVQAALS DPQIMNLVEE LPLGEFSPGR
     ISRTMMHSAL LKESSAKALL SSGYRLEYQK ALNGWIAQVS MRLGEESGVI STSYAKLFDV
     YFEGELDGAP YMFPDQNLSP QFYIQKMMIG PRVSSRVRNS YVDRIDVILR KDVVMRGFIT
     ANTILNVIEK LGTNHSVGDL VTVFTLMNIE TRVAEELAEY MTSEKIRFDA LKLLKKGIAG
     DEFTMSLNVA TQDFIDTYLA YPYQLTKTEV DAISLYCTQM VMLRAALGLP KKKMKIVVTD
     DAKKRYKIRL QRFRTHVPKI KVLKKLIDPN RMTVRNLENQ FV